Soft bearing materials that aim to reproduce the tribological function of the natural joint are gaining popularity as an alternative concept to conventional hard bearing materials in the hip and knee. However, it has not been proven so far that an elastic cushion bearing can be sufficiently durable as a long term ($20 years) articulating joint prosthesis. The use of new bearing materials should be supported by accurate descriptions of the implant following usage and of the number, volume, and type of wear particles generated. We report on a long-term 20 million cycle (Mc) wear study of a commercial hip replacement system composed of a compliant polycarbonate-urethane (PCU) acetabular liner coupled to a cobalt-chromium alloy femoral head. The PCU liner showed excellent wear characteristics in terms of its low and steady volumetric wear rate (5.8-7.7 mm 3 /Mc) and low particle generation rate (2-3 Â 10 6 particles/Mc). The latter is 5-6 orders of magnitude lower than that of highly cross-linked polyethylene and 6-8 orders of magnitude lower than that of metal-on-metal bearings. Microscopic analysis of the implants after the simulation demonstrated a low damage level to the implants' articulating surfaces. Thus, the compliant PCU bearing may provide a substantial advantage over traditional bearing materials. Keywords: total hip replacement; polycarbonate-urethane; bio-ferrography; filtration; fatigue A main concern in the developing implants for total hip replacement (THR) is the interaction between the implant's bearing surfaces as they contact during motion. Abrasive and adhesive wear mechanisms can lead to formation of wear debris. The accumulation of debris can activate macrophages to stimulate the production of antibodies, which attack the debris, the implant, and the surrounding bone. This process can cause osteolysis, aseptic loosening, and failure of the implant. 1,2 A new alternative, which has gained interest in recent years, is that of soft bearing materials aimed at reducing wear by maintaining a fluid film between the articulating surfaces, reproducing the tribological function of the natural joint. The theoretical and actual wear properties of soft orthopedic bearings have been explored since the 1980s. 3-5 These studies demonstrated clear advantages towards this type of bearing compared to hard bearings in terms of reduced friction and wear. Only recently, however, have cushion bearing implants been produced and their performance characterized in laboratory and animal studies. [6][7][8][9] The use of joint simulators provides a means of testing materials in prosthesis form under conditions similar to their intended use. A recent advancement in hip joint simulation is the realization that multidirectional motion reproduces clinically relevant wear mechanisms, wear debris, and wear magnitudes in polymer implants. 10 Thus, anatomical positioning, movement, and physiological loads that occur during normal gait must be correctly simulated, even while ignoring wider ranges of load and motion that...