Tribulosin and β-sitosterol-D-glucoside, the anthelmintic principles of Tribulus terrestris

Mundkinajeddu, Deepak; Dipankar, G.; D’Souza, Paschal; Asha, M.K.; Agarwal, Amit; Venkataraman, B. V.

doi:10.1078/094471102321621395

Cited by 71 publications

(52 citation statements)

References 12 publications

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“…Other chemical classes have been isolated from species of Justicia, such as essential oils, vitamins, fatty acids (docosanoic acid), and salicylic acid (Angonese et al, 1992;Al-Juaid & AbdelMojib, 2004). The steroids campesterol, stigmasterol, sitosterol, and sitosterol-D-glucoside were isolated from the leaves and roots of J. flava, J. spicigera, and J. gendarussa (Olaniyi, 1980;Wahi et al, 1974;Domínguez et al, 1990;Amborabé et al, 2002;Deepak et al, 2002;Rajakumar & Shivana, 2009). The literature describes the allelopathy effect of the sterols and triterpenes.…”

Section: Compounds Isolated From Species Of Justiciamentioning

confidence: 99%

Chemical constituents and biological activities of species of Justicia: a review

Corrêa¹,

Alcântara²

2012

Rev. bras. farmacogn.

125

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Abstract:The Acanthaceae family is an important source of therapeutic drugs, and the ethnopharmacological knowledge of this family requires urgent documentation as several of its species are near extinction. Justicia is the largest genus of Acanthaceae, with approximately 600 species. The present work provides a review addressing the chemistry and pharmacology of the genus Justicia. In addition, the biological activities of compounds isolated from the genus are also covered. The chemical and pharmacological information in the present work may inspire new biomedical applications for the species of Justicia, considering atom economy, the synthesis of environmentally benign products without producing toxic by-products, the use of renewable sources of raw materials, and the search for processes with maximal efficiency of energy.

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Section: Compounds Isolated From Species Of Justiciamentioning

confidence: 99%

Chemical constituents and biological activities of species of Justicia: a review

Corrêa¹,

Alcântara²

2012

Rev. bras. farmacogn.

125

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“…Ethyl gallate 1 was obtained from fraction 8 (10.6 mg), and β-sitosterol D-glucoside 2 was obtained from fraction 9 (23.0 mg). The structures of these compounds were identified by comparison of physical and spectroscopic data with those previously reported (El-Mawla, 2003;Cui et al, 2002;Deepak et al, 2002;De Souza et al, 2004;Savi et al, 2005).…”

Section: Isolation the Ethanol Extract Of M Heterophylla Showed Antmentioning

confidence: 99%

Isolation of the active compound in Mauria heterophylla, a peruvian plant with antibacterial activity

Mori

Chang

Maúrtua

et al. 2006

Phytotherapy Research

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“…Leaves of J. gendarussa were used by the healers for treatment of helminthiasis in children (see Serial Number 3). The leaves are known to contain -sitosterol (Duke, 1992), which reportedly possess anthelmintic properties (Deepak et al, 2002). Honey was used with leaf juice to make the mixture more palatable to children.…”

Section: Discussionmentioning

confidence: 99%

Medicinal formulations of a Kanda tribal healer – a tribe on the verge of disappearance in Bangladesh

Rahmatullah

Ayman²,

Akter³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

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The Kanda tribe is one of the lesser known small tribes of Bangladesh with an estimated population of about 1700 people (according to them), and on the verge of extinction as a separate entity. To some extent, they have assimilated with the surrounding mainstream Bengali-speaking population, but they still maintain their cultural practices including traditional medicinal practices, for which they have their own tribal healers. Nothing at all has been documented thus far about their traditional medicinal practices and formulations, which are on the verge of disappearance. The Kanda tribe can be found only in scattered tea gardens of Sreemangal in Sylhet district of Bangladesh; dispersion of the tribe into small separated communities is also contributing to the fast losing of traditional medicinal practices. The objective of the present study was to conduct an ethnomedicinal survey among the traditional healers of the Kanda tribe (in fact, only one such healer was found after extensive searches). Information was collected from the healer with the help of a semi-structured questionnaire and the guided field-walk method. A total of 24 formulations were obtained from the healer containing 34 plants including two plants, which could not be identified. Besides medicinal plants, the Kanda healer also used the body hairs of the Asiatic black bear (Ursus thibetanus) and bats (Pteropus giganteus giganteus) in one of his formulation for treatment of fever with shivering. The ailments treated by the Kanda healer were fairly common ailments like cuts and wounds, skin diseases, helminthiasis, fever, respiratory problems (coughs, asthma), gastrointestinal disorders (stomach pain, constipation, diarrhea), burning sensations during urination, various types of pain (headache, body ache, toothache, ear ache), conjunctivitis, poisonous snake, insect or reptile bites, jaundice, and bone fractures. A number of important drugs in allopathic medicine like quinine, artemisinin, and morphine (to name only a few) have been discovered from observing indigenous medicinal practices. From that view point, the formulations used by the Kanda healer merit scientific studies for their potential in the discovery of cheap and effective new drugs. Scientific validation of the medicinal formulations of the Kanda healer can also be effective for treatment of ailments among this tribe, which does not have or does not want to have any contact with modern medicine.

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Tribulosin and β-sitosterol-D-glucoside, the anthelmintic principles of Tribulus terrestris

Cited by 71 publications

References 12 publications

Chemical constituents and biological activities of species of Justicia: a review

Chemical constituents and biological activities of species of Justicia: a review

Isolation of the active compound in Mauria heterophylla, a peruvian plant with antibacterial activity

Medicinal formulations of a Kanda tribal healer – a tribe on the verge of disappearance in Bangladesh

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