Tribulus terrestris ameliorates carbon tetrachloride-induced hepatotoxicity in male rats through suppression of oxidative stress and inflammation

Comparative Histological Study of Therapeutic Effect of Mesenchymal Stem Cells versus Mesenchymal Stem Cells Co-Cultured with Liver Tissue on Carbon Tetrachloride-Induced Hepatotoxicity in Adult Male Albino Rats

“…[ 46 ] In addition, CCl 4 initiates fat mobilization from adipose tissue where it accumulates and damage the membranes of hepatocytes ER, leading to decline in the synthesis of enzymes and apoproteins that form complexes with triglycerides facilitating their secretion. [ 47 ]…”

Promising phytopharmacology, nutritional potential, health benefits, and traditional usage of Tribulus terrestris L. herb

“…The liver plays a crucial role in the body's immune system, detoxification system, and metabolic processes. Increased free radical production occurs during metabolism, and oxidative stress can cause liver damage leading to liver diseases [ 74 , 75 ]. Additionally, several factors such as drinking alcohol, exposure to viral infections, and exposure to toxins can lead to liver harm.…”

“…The aqueous extract of T. terrestris and silymarin had a significant protective effect against liver damage induced by the hepatotoxin carbon tetrachloride in rats. The T. terrestris extract was found to have cytoprotective effects and to restore hepatic architecture by lowering the levels of liver enzymes such as ALT, AST, ALP, and lipid peroxidation while increasing the levels of antioxidants such as glutathione and superoxide dismutase (SOD) in the liver tissue [ 75 ]. Similarly, hepatoprotective effects of T. terrestris , Ashwagandha, and N-acetylcysteine were measured by Ref.…”

“…Various studies have explored the effectiveness of T. terrestris in safeguarding and rejuvenating liver function when it comes to exposure to toxic substances such as heavy metals found in the environment. It has been discovered that T. terrestris is capable of successfully restoring liver markers that have been negatively impacted by toxic substances such as aluminum, cadmium, mercury, arsenic, CYP, and CCl4 [ 75 , 81 ]. Further analysis of the data revealed that T. terrestris has the potential to shield the liver from a wide range of threats.…”

Diosgenin inhibits the proliferation of gastric cancer cells via inducing mesoderm posterior 1 down-regulation-mediated alternative reading frame expression

“…The dry fruits of TT, as a traditional herb medicine (commonly named “Ji Li”), have been used for more than thousands of years in China within the context of protecting the liver, activating blood circulation, improving eyesight, and relieving itching (Chinese Pharmacopoeia, 2015 version). Modern studies have shown that TT has various pharmacological effects including anti-inflammatory, 13 anti-oxidant, 14 anti-bacterial, 15 anti-aging, 16 and anti-tumor activities. 17,18 The main active ingredients of T. terrestris include diosgenin, ruscogenin, hecogenin, gitogenin, tribuloside, astragalin, and harmine; 19 however, which ingredient exerts the anti-tumor activity and its underlying mechanisms remain unclear.…”