Trichilemmal Carcinoma of the Scalp in a Young Female: A Case Report

Jia, Quanli; Y, Yuan; D, Mao; Wen, Guanghui; Chen, Xinrong

doi:10.2147/ccid.s349797

Cited by 8 publications

(3 citation statements)

References 15 publications

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“…[7][8][9][10] A clear guideline for treatment has not yet been presented, but a wide excision with a safety margin of 1 cm arriving at the periosteum is required in MPTC. [11][12][13][14] Recently, Moh micrographic surgery achieved good results. However, because the probability of local recurrence between 6 months and 10 years is 3.7%, continuous monitoring is required.…”

Section: Discussionmentioning

confidence: 99%

A malignant proliferating trichilemmal cyst arising on the elbow of a man: A case report and review of the literature

Lee¹,

Han²,

Yoon³

2023

Medicine

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Introduction: Trichilemmal cysts (TCs) are common benign cysts that form from the hair follicles in the skin. Proliferating trichilemmal cysts (PTCs) are rare types of TCs characterized by rapid cellular proliferation. Malignant transformation of PTC (MPTC) is a rare adnexal tumor that account for <0.1% of all skin cancers. TCs and PTCs are benign tumors; however, MPTCs grow rapidly and are prone to metastasis. Case presentation: A 77-year-old man was referred to our hospital with a solitary pinkish mass on his left elbow. Trichilemmal carcinoma arising from a PTC was confirmed through excisional biopsy, and wide excision was performed. One month postoperatively, a cystic mass was observed and was suspected to have local recurrence; however, bursitis was confirmed after excisional biopsy. After 1 year of follow-up, the patient maintained an improvement without recurrence or any other surgical complications. Conclusions: In addition to being a very rare disease, MTPC occurred in the elbow of a man who does not fit the general etiology; therefore, it is considered an interesting case, and we report this case for academic contribution.

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Section: Discussionmentioning

confidence: 99%

A malignant proliferating trichilemmal cyst arising on the elbow of a man: A case report and review of the literature

Lee¹,

Han²,

Yoon³

2023

Medicine

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“…Complete surgical excision with tumor-free margins is the most common treatment, and re-excision is strongly recommended if the histologic excision margins are not totally free (5,6). Mohs micrographic surgery (MMS) has been shown to be an ideal option recently because it provides a tissue-sparing method for complete surgical removal of the tumor while preserving the surrounding healthy tissue (7)(8)(9).…”

Section: Discussionmentioning

confidence: 99%

Axillary lymph node dissection combined with radiotherapy for trichilemmal carcinoma with giant lymph node metastasis: A case report

Zheng

Guan

et al. 2022

Front. Oncol.

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BackgroundTrichilemmal carcinoma (TC) is a rare malignancy with a poor outcome if local recurrence and distant metastasis occur. There is no treatment strategy for such a disease.Case presentationWe reported a complicated case of TC in the right lower abdomen with ipsilateral axillary and inguinal lymph node metastases. After surgery and radiotherapy, there has been no recurrence or metastasis in the follow-up to date.ConclusionWe believe that even though considered a tumor of low malignant potential, TC still has the risk of recurrence and metastasis, and the lymph node status should be identified if a high suspicion or diagnosis is made. Regional lymph node dissection followed by local radiotherapy is recommended as the optimal treatment strategy for patients with lymph node metastases of TC. Screening for metastasis and close follow-up are indispensable for improving prognosis.

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“…As first described and defined by Headington, trichilemmal carcinoma (TLC) is a rare malignant adnexal neoplasm and exhibits features of “outer root sheath differentiation and atypical clear cell neoplasm” ( 1 , 2 ). Clinically, TLC usually manifests as an asymptomatic exophytic or polypoid masses and may be misdiagnosed as basal cell carcinoma (BCC), squamous cell carcinoma (SCC), keratoacanthoma, or proliferating pilar cyst ( 3 ). Generally manifested as an indolent course, TLC may still be locally destructive and may have the possibility of recurrence or metastasis, which implies the significance of accurate diagnosis and careful management.…”

Section: Introductionmentioning

confidence: 99%

Systematic analysis and case series of the diagnosis and management of trichilemmal carcinoma

Sun

Zhang²,

Xiao³

et al. 2023

Front. Oncol.

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BackgroundTrichilemmal carcinoma (TLC) is a rare malignant cutaneous adnexal neoplasm, with no relatively comprehensive research.ObjectiveThe aim of this study is to perform an updated statistical analysis so as to better understand TLC’s epidemiology, clinical features, diagnosis, and treatment.MethodsThe diagnosis and treatment of three TLC cases in our department were summarized. Then, all TLC cases published in the literature were retrieved for a comprehensive analysis, followed by the analysis of global trends and regional distribution, demographic characteristics, clinical features, pathogenesis, histopathological features, and treatment and prognosis of TLC.ResultsOf the 231 cases, the incidence of TLC has shown an upward trend recently, especially in China, in Asia. The susceptible population is men aged 60–80 and women over 80, and the most prone location is head and neck. The phenotype of TLC is not always typical and may be misdiagnosed because of the coexistence of other diseases. There is a linear relationship between the diameter and its duration or thickness. UV, locally present skin lesions, trauma, scarring, organ transplantation, and genetic disorders may trigger the occurrence of TLC. Periodic acid–Schiff staining and CD34, but not Epithelial Membrane Antigen (EMA), were helpful in the diagnosis of TLC. Although effective, surgical excision and Mohs micrographic surgery need further improvement to reduce recurrence of TLC. Carcinoma history is an independent risk factor for TLC recurrence.LimitationsThe limitation of this study is the lack of randomized controlled trial on TLC treatment and recurrence.ConclusionTLC has the possibility of invasive growth and recurrence, especially in patients with longer duration and carcinoma history.

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Trichilemmal Carcinoma of the Scalp in a Young Female: A Case Report

Abstract: Trichilemmal carcinoma (TC) is a rare malignant cutaneous adnexal neoplasm originating from the outer root sheath of hair follicles, which occurs commonly in sun-exposed areas of the elderly. Here, we introduce a case of a 24-year-old woman with TC on her scalp.

Cited by 8 publications

References 15 publications

A malignant proliferating trichilemmal cyst arising on the elbow of a man: A case report and review of the literature

A malignant proliferating trichilemmal cyst arising on the elbow of a man: A case report and review of the literature

Axillary lymph node dissection combined with radiotherapy for trichilemmal carcinoma with giant lymph node metastasis: A case report

Systematic analysis and case series of the diagnosis and management of trichilemmal carcinoma

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