Trichinella spiralis Thioredoxin Peroxidase 2 Regulates Protective Th2 Immune Response in Mice by Directly Inducing Alternatively Activated Macrophages

Jin, Qi-Wang; Zhang, Nian‐Zhang; Li, Wenhui; Qin, Hong-Tao; Liu, Yin-Ju; Ohiolei, John Asekhaen; Niu, Dong-Yu; Yan, Hong‐Bin; Li, Li; Jia, Wan‐Zhong; Song, Mingxin; Fu, Bao‐Quan

doi:10.3389/fimmu.2020.02015

Cited by 19 publications

(12 citation statements)

References 42 publications

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“… 96 Thioredoxin peroxidase-2 of Trichinella spiralis can induce alternative activation of macrophages and differentiation of naïve T cells into Th2 cells in vitro. 97 Cystatin of Trichinella spiralis can inhibit the Th1-type immune response by inducing production of IL-4 and Treg cells in TNBS-induced colitis. 98 Peroxiredoxin secreted by Schistosoma mansoni or Fasciola hepatica can induce the alternative activation of macrophages and the activation of naive T cells to secrete IL-4, IL-5 and IL-13.…”

Section: The Immunoregulatory Mechanisms Of Identified Helminth-derived Moleculesmentioning

confidence: 99%

Helminth Therapy for Immune-Mediated Inflammatory Diseases: Current and Future Perspectives

Shi¹,

Xu²,

Wang³

et al. 2022

JIR

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Inflammatory bowel disease and allergic asthma, as typical immune-mediated inflammatory diseases (IMIDs), are associated with immune imbalance caused by complex interactions among environmental, genetic and bacterial factors. The changing immune imbalance of IMIDs not only causes serious pathological damages but also increases the difficulty of treatment. Helminths or helminth-derived molecules have been increasingly employed to treat IMIDs due to their immunoregulatory ability. Since helminth infection is not an appropriate treatment direction due to the complex immunoregulation and safety concerns, one of the new therapies is to harness the immunoregulation induced by the identified helminth-derived molecules using immune indexes as a guide. This review discusses the pathogenesis of inflammatory bowel disease and allergic asthma, and summarizes the therapeutic effect of helminths and the immunoregulatory mechanisms induced by helminth-derived molecules proposing therapeutic regimens.

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Section: The Immunoregulatory Mechanisms Of Identified Helminth-derived Moleculesmentioning

confidence: 99%

Helminth Therapy for Immune-Mediated Inflammatory Diseases: Current and Future Perspectives

Shi¹,

Xu²,

Wang³

et al. 2022

JIR

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“…As an example of in vitro analyses, Jin et al (2020b) investigated the immunomodulatory effect of T. spiralis muscle larvae thioredoxin peroxidase-2 (TsTPX2) in the regulation of Th2 response. They found that rTsTPX2 could directly drive peritoneal macrophages to the AAM phenotype.…”

Section: How Does Trichinella Tame the Host Immune...mentioning

confidence: 99%

“…The immunomodulatory effect of T. spiralis thioredoxin peroxidase-2 (TsTPX2), a protein derived from T. spiralis muscle larvae ES products was investigated by Jin et al (2020b) . They stated that TsTPX2 could suppress Th1 immune responses and promoting Th2 cytokines, IL-4 and IL-10 via polarization of macrophages into the AAM phenotype.…”

Section: Trichinella -Derived Molecules: a Panacea For Moder...mentioning

confidence: 99%

Trichinella-induced immunomodulation: Another tale of helminth success

Bruschi

Ashour

Othman

2022

Food and Waterborne Parasitology

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“…Some of these proteins have been studied for immunity in other parasitic worms. For example, the Trichinella spiralis ES product thioredoxin peroxidase-2 could induce macrophages towards an M2-like phenotype, both in vivo and in vitro, and CD4 + T cells increased in number after immunization of mice with rTsTPX2 and this mediated the expulsion of worm from the host to protect them, thus suggesting TsTPX2 was a potential vaccine candidate against trichinosis [30]. Also, thioredoxin peroxidase was signi cantly recognized by melioidosis-positive sera in cysticercus stage, for which strong immunogenic properties rendered it an anticipated vaccine target [31].…”

Section: Discussionmentioning

confidence: 99%

Comparative Proteomic Analysis of Taenia solium Cysticercus and Adult Stages

Zhou

et al. 2022

Preprint

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B ack ground : Cysticercosis is one of 20 tropical diseases classified as neglected by the World Health Organization (WHO). As the pathogenesis of cysticercosis is not yet clear, there is no vaccine that can completely cure the disease. This study attempts to identify the proteins of adult and larvae of Taenia solium by mass spectrometry, predict the function of differential proteins so as to further study the Pathogenic mechanism of larvae to host. This provides clues for the cysticercosis prevention and treatment. Methods: In our study, we separated proteins of adult and larvae of Taenia solium by High Performance Liquid Chromatography(HPLC) fractionation, and protein samples were also digested in liquid and identified by liquid chromatography tandem mass spectrometry(LC-MS/MS); the differentially expressed proteins were then processed by a bioinformatics and parallel reaction monitoring (PRM) analysis . Results: Our results showed that the 3658 proteins identified, 2481 contained quantitative information, according to the relative quantitative analysis of the protein expression level by label-free quantification, differentially expressed proteins between the two treatments were identified applying a P value < 0.05 and a twofold change threshold, of which 293 proteins were up-regulated whereas 265 proteins were down-regulated. Through the bioinformatics analysis, we found some proteins that were associated with the immune effector process in addition to diagnostic antigens and therapeutic targets. Conclusion: We conclude that the results facilitate a better understanding of the complexity of the cestode life cycle, mechanism to counter the host immune system, and host–parasite interactions in both developmental stages. Evading the host immune response may be key for the establishment of latent and persistent infections by cysticercus. Therefore, understanding the mechanisms through which the parasites manipulate the host immune response for their survival is important to our understanding of the intricate parasite-host interaction. Further studies are required to identify what function those proteins are, it may contribute to the development of novel strategies and vaccines against cysticercosis.

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Trichinella spiralis Thioredoxin Peroxidase 2 Regulates Protective Th2 Immune Response in Mice by Directly Inducing Alternatively Activated Macrophages

Cited by 19 publications

References 42 publications

Helminth Therapy for Immune-Mediated Inflammatory Diseases: Current and Future Perspectives

Helminth Therapy for Immune-Mediated Inflammatory Diseases: Current and Future Perspectives

Trichinella-induced immunomodulation: Another tale of helminth success

Comparative Proteomic Analysis of Taenia solium Cysticercus and Adult Stages

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