Trichloroacetic Acid

Harmon, Christopher B.; Hadley, Michael S.; Tristani, Payam

doi:10.1007/978-3-642-20270-4_5

Cited by 4 publications

(3 citation statements)

References 3 publications

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“…We hypothesize that because the penetration studies were run for 24 h, the TCA effectively acted as a powerful penetration enhancer, heavily or fully impairing the outermost stratum corneum of the skin barrier to allow L‐Lactic acid‐ 13 C 3 to be delivered unimpeded into the skin. TCA operates in part by diminishing corneocyte adhesion, 31,32 which would weaken or completely eliminate the chief barrier to active delivery into the skin 33 . 20% TCA in particular will cause significant levels of destruction to the skin barrier, resulting in the well‐known “frosting” effect seen in chemical peels with high levels of TCA 34,35 .…”

Section: Discussionmentioning

confidence: 99%

MALDI Mass Spectrometry Imaging and Semi‐Quantification of Topically Delivered Lactic Acid

Cohen,

Legouffe,

Mao

et al. 2023

Skin Research and Technology

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BackgroundLactic acid is a common active ingredient in many topical skincare products; however, measuring its delivery into the skin is challenging due to the presence of a large level of endogenous lactic acid. In this study, matrix‐assisted laser desorption/ionization mass spectrometry imaging (MALDI‐MSI) was used to quantitatively and qualitatively measure the delivery of lactic acid into the skin from a range of topical skincare products.Materials and methodsPorcine skin samples were treated with various skincare products containing lactic acid. After 24 h, skin samples were sectioned and treated via H&E staining or prepared for MALDI‐MSI using chemical derivatization. Samples were then analyzed by MALDI‐MSI imaging to obtain lactic acid distribution in the entire skin section.ResultsDue to the high level of endogenous lactic acid in the skin, a “triple isotope” of lactic acid (L‐Lactic acid‐13C3), was needed to provide full resolution from the skin's background signal with MALDI‐MSI. With this approach, the topically delivered lactic acid could be quantitatively and qualitatively analyzed from a variety of skincare products.ConclusionsThe combination of L‐Lactic acid‐13C3 and MALDI‐MSI was successfully used to quantitatively and qualitatively measure the topical delivery of lactic acid from a variety of skincare products. This approach could be used in future work to better understand the mode of action of lactic acid as an active ingredient in skincare products.

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Section: Discussionmentioning

confidence: 99%

MALDI Mass Spectrometry Imaging and Semi‐Quantification of Topically Delivered Lactic Acid

Cohen,

Legouffe,

Mao

et al. 2023

Skin Research and Technology

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“…The higher the concentration or amount of TCA applied, the more intense the destructive effect is. Therefore, it may represent an alternative strategy for skin tumor [ 9 , 10 ]. Considering the location, number and size of the lesion, we chose 80% TCA as the treatment option in this case.…”

Section: Discussionmentioning

confidence: 99%

Unusual clinical manifestation of seborrheic keratosis on the scalp successfully treated with topical trichloroacetic acid: an atypical case report

Komalasari¹,

Djawad²,

Sumarheni³

et al. 2020

Pan Afr Med J

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“…Trichloroacetic acid (TCA) is a common laboratory chemical which used to induce HCC in rats by increasing inflammation and oxidative stress (Fouad et al, 2013). TCA induces tumours in laboratory animals through potential mechanisms such as DNA hypomethylation, peroxisome proliferation, oncogene activation, cell proliferation, and inhibition of intercellular communication (Harmon et al, 2011). Systemic treatment options for liver cancer are limited, and only a few are available.…”

Section: Introductionmentioning

confidence: 99%

Attenuation of trichloroacetic acid-induced hepatocellular carcinoma by Artemisia judaica ethanolic extract in male rats

Mokhamer

Zidan

El.Ghayesh

et al. 2022

JoBAZ

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Background The liver cancer is one of the most frequent solid organ malignancies worldwide. Alternative medicine is deemed as one approach that may progress anticancer drugs efficacy and minimize their toxic effects. Similarly, this study was designed to establish the ethanolic extract from Artemisia judaica (AJ) plant and characterize extract that formed using gas chromatography–mass spectrometry analysis, then evaluate their anti-tumour activity alone or in combination with cyclophosphamide(CTX) against trichloroacetic acid (TCA)-induced hepatocellular carcinoma in rats. Results The obtained results revealed that a significant elevation in serum transaminases (ALT, AST), and alkaline phosphatase activities, as well as total serum bilirubin (T.Bil) levels, was recognized in TCA injected rats compared with the control group. In contrast, a significant decrease in liver antioxidant enzymes superoxide dismutase and catalase activities, as well as reduced glutathione level was observed in TCA treated rats compared with the control group. Furthermore, administration of AJ alone or in combination with CTX in rats presented a significant amelioration in all mentioned parameters and attenuated the increased malondialdehyde level in liver tissues compared to the TCA group. Conclusions It could be suggested that AJ hepatoprotective effect against chemical-induced hepatocarcinogenesis in combination with chemotherapy drug by reducing chemotherapy side effects confirmed by haematoxylin and eosin stain (H&E) observations, improvement of oxidative stress biomarkers, and liver enzymes.

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Trichloroacetic Acid

Cited by 4 publications

References 3 publications

MALDI Mass Spectrometry Imaging and Semi‐Quantification of Topically Delivered Lactic Acid

MALDI Mass Spectrometry Imaging and Semi‐Quantification of Topically Delivered Lactic Acid

Unusual clinical manifestation of seborrheic keratosis on the scalp successfully treated with topical trichloroacetic acid: an atypical case report

Attenuation of trichloroacetic acid-induced hepatocellular carcinoma by Artemisia judaica ethanolic extract in male rats

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