Trichloroacetimidate-Triggered Expeditious and Novel Synthesis of N-Acylbenzotriazoles

Abstract

A facile route for the synthesis of diverse range of N-acylbenzotriazole derivatives from corresponding carboxylic acids has been established through carbonyl activation pathway. In this method, trichloroacetonitrile is performed as an effective reagent for an easy access of N-acylbenzotriazoles which was simply proceed through the activation of carboxylic acids via in situ imidate formation in anhydrous 1,2 dichloroethane followed by addition of 1H-benzotriazole at 80 oC for 3-4 hours. Easy handling, one-pot, and metal-free condition demonstrate the notable merits of the devised protocol.

From traditional to greener alternatives: potential of plant resources as a biotransformation tool in organic synthesis

“…A major challenge in modern synthetic chemistry is the development of environment-friendly and economically viable reaction routes 1 that can reduce pollution at their source, elevating them to the pinnacle of the pollution-prevention hierarchy. Stoichiometric reagents, mostly inorganic compounds, are a significant source of waste, notably in the production of fine chemicals and active pharmaceutical ingredients.…”