Trichomonas Vaginalis Infection in the Male

Coutts, Waldemar E.; Vargas-Salazar, R.; Silva-Inzunza, Edna; Olmedo, Rolando Daniel Paredes; Turteltaub, R.; Saavedra, José M.

doi:10.1136/bmj.2.4944.885

Cited by 15 publications

(9 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An incubation period of 3 to 8 days for trichomonal urethritis was postulated by Coutts and Silva-Inzunza(1952). In his series of 126 men, Catterall (1960) found that their average age was 33 years, that 14-3 per cent.…”

mentioning

confidence: 99%

Natural History of Trichomonal Infection in Males

Weston¹,

Nicol²

1963

Sexually Transmitted Infections

View full text Add to dashboard Cite

mentioning

confidence: 99%

Natural History of Trichomonal Infection in Males

Weston¹,

Nicol²

1963

Sexually Transmitted Infections

View full text Add to dashboard Cite

“…Liston and Lees (1940) recommended searches for the parasite in cases of epididymitis of unknown aetiology and described one case similar to the one presented here. Coutts, Vargas-Salazar, Silva-Inzunza, Olmedo, and Turteltaur (1955) claimed to have found the parasite in biopsy specimens from three cases of epididymitis, but these workers generally used staining methods for identification and the fact that they claimed to have found T. vaginalis by this method in 68 per cent. of 2,482 cases of nongonococcal urethritis in men must cast doubt on their findings in epididymitis.…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Epididymitis due to Trichomonas vaginalis.

Fisher¹,

Morton²

1969

Sexually Transmitted Infections

View full text Add to dashboard Cite

In a recent analysis of 75 cases of non-gonococcal epididymitis, Fowler (personal communication) found no causative organism in 52 (69 per cent.).Mittemeyer, Lennox, and Borski (1966) culture of another portion of this centrifuged urine deposit failed to reveal gonococci and culture of a fresh mid-stream specimen of urine was bacteriologically sterile.Therapy A 7-day course of metronidazole 200 mg. three times a day was ordered and the penicillin therapy was continued.After 4 days there was a very slight mucoid urethral discharge but the urine was macroscopically clear. Stained smears, wet films, and cultures of urethral material and of urine for gonococci and T. vaginalis gave negative results.After a further 4 days the findings were unchanged and a mid-stream specimen of urine was reported as being normal. The chest X ray, haemoglobin, white cell count, and erythrocyte sedimentation rate were also normal. 3 weeks later the epididymitis had almost resolved and examination of the centrifuged urine showed no T. vaginalis.Result When last seen, about 5 weeks after the initial visit, the patient was asymptomatic and had no abnormal signs apart from a fibrosed lower pole of the left epididymis. Unfortunately his transfer to one of H.M. Prisons prevented further follow-up.Contact Tracing His girl-friend was seen at a neighbouring clinic; she was found to have both gonorrhoea and trichomonal vaginitis. DiscussionThere is very little in the literature about epididymitis due to T. vaginalis. Liston and Lees (1940) recommended searches for the parasite in cases of epididymitis of unknown aetiology and described one case similar to the one presented here. Coutts, Vargas-Salazar, Silva-Inzunza, Olmedo, and Turteltaur (1955)

show abstract

“…CAR NIDAZOLE human trichomoniasis, although none were particularly effective (1,30 This review will focus only on the mechanism of toxicity ofthe nitro compounds currently used for the treatment of human and animal trichomoniasis. The literature on several nitroimidazoles and nitrofurans which have been used against trichomoniasis has been ably reviewed over the yearsby several authors (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29).…”

Section: C2nmentioning

confidence: 99%

“…Until the late-1950s there was no successful, specific treatment for trichomoniasis (30 (34). They are commonly used to reduce the risks of infection by anaerobic organisms after colonic surgery (34).…”

Section: Drugs Used In the Chemotherapy Of Trichomoniasismentioning

confidence: 99%

Mechanism of Toxicity of Nitro Compounds Used in the Chemotherapy of Trichomoniasis

Moreno¹,

Docampo²

1985

Environmental Health Perspectives

View full text Add to dashboard Cite

The mechanism of the trichomonicidal activity of metronidazole and other 5-nitroimidazoles appears to depend on the ferredoxin-mediated reduction of their nitro group, with generation of a reactive metabolite or metabolites which interact with DNA leading to a subsequent inhibition of nucleic acid and protein synthesis. Redox cycling of these compounds under aerobic conditions appears to be a detoxification reaction by inhibiting net reduction of the drugs, thereby inhibiting their uptake. On the other hand, redox cycling of nitrofurans or other compounds with more positive reduction potential results in formation of high steady-state concentrations of oxygen-derived metabolites that might be of toxicological significance. It seems likely that reduced metabolites of nitroimidazoles (perhaps through covalent binding to tissue macromolecules and/or thiols depletion) are also involved in the nitroimidazoles' toxic effects to animal tissues and in their mutagenic and carcinogenic action.

show abstract

Trichomonas Vaginalis Infection in the Male

Cited by 15 publications

References 3 publications

Natural History of Trichomonal Infection in Males

Natural History of Trichomonal Infection in Males

Epididymitis due to Trichomonas vaginalis.

Mechanism of Toxicity of Nitro Compounds Used in the Chemotherapy of Trichomoniasis

Contact Info

Product

Resources

About