Trichophyton Fungal Keratitis

Mohammad, Abdulkarim; AlRajhi, Abdulaziz; Wagoner, Michael D.

doi:10.1097/01.ico.0000164834.77291.51

Cited by 16 publications

(12 citation statements)

References 19 publications

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“…In this case, we report the first case of keratitis and onychomycosis infected by Trichophyton species simultaneously. Although Mohammad et al reported 5 cases of Trichophyton fungal keratitis, none of the patients has been reported to have the concurrent mycotic skin diseases [5]. The ocular involvement can be caused by spreading from an adjacent skin lesion or from a distant infected source outside the patient [8].…”

Section: Discussionmentioning

confidence: 99%

“…In this case, the type of Trichophyton species was not identified. Through the expression an extracellular collagenase with keratinolytic potential, Trichophyton species can cause a severe stromalysis leading to the loss of vision [5,10]. Rapid diagnosis and aggressive medical treatment is of most importance to preserve the vision and have better therapeutic results [1,5].…”

Section: Discussionmentioning

confidence: 99%

“…Through the expression an extracellular collagenase with keratinolytic potential, Trichophyton species can cause a severe stromalysis leading to the loss of vision [5,10]. Rapid diagnosis and aggressive medical treatment is of most importance to preserve the vision and have better therapeutic results [1,5]. Shenoy et al [8] reported a case of Trichophyton keratitis that was not responding to 5% natamycin and treated with topical 2% fluconazole.…”

Section: Discussionmentioning

confidence: 99%

“…The most common pathogens of fungal keratitis are Candida albicans and Fusarium species [2], although the prevalent species differ in different geographical areas of the world [1]. Trichophyton is a wide distributed species of dermatophyte and a common pathogen of tinea capitis, flavus, and onychomycosis in dermatologic area [3,4], even though Trichophyton keratitis is not common [5,6]. Early identification of pathogen causing keratitis provides the appropriate treatment in early phase of keratitis, resulting in better prognosis.…”

Section: Introductionmentioning

confidence: 99%

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A case of fungal keratitis and onychomycosis simultaneously infected by Trichophyton species

et al. 2014

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BackgroundFungal keratitis is difficult to treat that can result in corneal blindness requiring penetrating keratoplasty and in fungal endothalmitis. We report a case of fungal keratitis and onychomycosis simultaneously infected by Trichophyton.Case presentationA 77-year old male presented with ocular pain, conjunctival injection, and severe loss of vision in his left eye. His best corrected visual acuity was hand movements in the left eye, and slit-lamp examination showed a corneal ulcer with feathery margin and hypopyon. Bacterial and fungal smear/culture showed no organism, and there was no improvement in spite of treatment with topical fortified 5% cefazolin and 2% tobramycin. Trichophyton species was identified by repeated cultures. We found onychomycosis on the patient’s foot, where the same fungal species were identified. Regimen was changed to topical itraconazole and systemic intravenous itraconazole. No clinical improvement was observed, so therapeutic penetrating keratoplasty and cryotherapy was done with continuation of antifungal therapy. The graft was clear at postoperative 1 month and no evidence of recurrence was found.ConclusionIt is important to identify the pathogen of keratitis because early identification of pathogen causing keratitis provides the appropriate treatment in early phase of keratitis. It is necessary to search for other fungal skin infections such as onychomycosis and athelete’s foot considering the fungal keratitis following skin infection. In addition, fungal skin infection including onychomycosis should be treated for prevention of fungal keratitis as soon as possible.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A case of fungal keratitis and onychomycosis simultaneously infected by Trichophyton species

et al. 2014

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“…This corresponds to the previous report of Trichophyton keratitis. 14 The benefit of systemic antifungal agents cannot be evaluated because systemic antifungal agents were not used. We did not explore possible surgical interventions such as lamellar keratoplasty because our patient responded to the drug regimen.…”

Section: Discussionmentioning

confidence: 99%

Epidermophyton fungal keratitis following laser-assisted subepithelial keratectomy

Jung¹,

Kwon²,

Lee³

et al. 2009

Journal of Cataract and Refractive Surgery

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A 40-year-old man developed pain, decreased vision, and a corneal infiltrate 10 days after laser-assisted subepithelial keratectomy. Treatment with conventional topical and systemic antibiotic agents did not improve the symptoms. Approximately 2 weeks after surgery, the patient was referred to Kim's Eye Hospital, presenting with counting fingers visual acuity, moderate anterior chamber reaction, and multifocal stromal infiltrates in the left eye. The corneal infiltrate findings were suggestive of fungal keratitis, and corneal smears were positive for septate fungal hyphae. Treatment with topical amphotericin B was initiated, but there was little response. After mycology culture and molecular analysis identified Epidermophyton floccosum as the infectious organism, topical natamycin was added and the infiltrate gradually resolved. Three weeks after treatment with natamycin, the corrected visual acuity was 20/25. Treatment with topical natamycin was effective against Epidermophyton keratitis.

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Favus of the Scalp: An Overview and Update

İlkit

2010

Mycopathologia

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Tinea capitis favosa, a chronic inflammatory dermatophyte infection of the scalp, affects over 90% of patients with anthropophilic Trichophyton schoenleinii. T. violaceum, T. verrucosum, zoophilic T. mentagrophytes (referred to as 'var. quinckeanum'), Microsporum canis, and geophilic M. gypseum have also been recovered from favic lesions. Favus is typically a childhood disease, yet adult cases are not uncommon. Interestingly, favus is less contagious than other dermatophytoses, although intrafamilial infections are reported and have been widely discussed in the literature. Clinical presentation of T. schoenleinii infections is variable: this fungus can be isolated from tinea capitis lesions that appear as gray patches, but symptom-free colonization of the scalp also occurs. Although in the past T. schoenleinii was the dominant fungus recovered from dermatophytic scalp lesions, worldwide the incidence has decreased except in China, Nigeria, and Iran. Favus of the glabrous skin and nails are reported less frequently than favus of the scalp. This review discusses the clinical features of favus, as well as the etiological agents, global epidemiology, laboratory diagnosis, and a short history of medical mycology.

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Trichophyton Fungal Keratitis

Abstract: Trichophyton schoenleinii is a rare cause of fungal keratitis that may be associated with progressive keratolysis and perforation, scleral extension, and endophthalmitis. Therapeutic keratoplasty may be successful in achieving cure in medically unresponsive cases.

Cited by 16 publications

References 19 publications

A case of fungal keratitis and onychomycosis simultaneously infected by Trichophyton species

A case of fungal keratitis and onychomycosis simultaneously infected by Trichophyton species

Epidermophyton fungal keratitis following laser-assisted subepithelial keratectomy

Favus of the Scalp: An Overview and Update

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