Trichoscopy in anagen effluvium: Extensive peripilar sign

Malakar, Subrata; Mehta, Purva; Malakar, Surit

doi:10.7241/ourd.20174.140

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…Although PPS has been frequently reported in AGA with frequencies ranging from 31% to 90% [6,[15][16][17], it has also been reported in other types of hair loss not associated with PFI such as telogen effluvium [4,[16][17][18], anagen effluvium [19] as well as in normal people [20] indicating that there must be an explanation other than PFI for PPS.…”

Section: Discussionmentioning

confidence: 99%

Peripilar Sign in Androgenetic Alopecia: Does It Really Indicate Peripilar Infiltrate?

Abdalla,

Bosseila,

R.E. Abdel-Halim

et al. 2024

Dermatol Pract Concept

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Introduction: Peripilar sign (PPS) is a trichoscopic sign that was first described in androgenetic alopecia (AGA) and is thought to reflect the presence of perifollicular infiltrate (PFI) in histopathology. Objectives: To study PPS in a cohort of patients with AGA and to assess its validity as a sign indicative of PFI. Methods: One hundred patients with AGA (confirmed by trichoscopic examination) were recruited in this cross-sectional study. From those patients, frontal scalp biopsy was done for two subgroups, 22 patients with PPS and 23 patients without PPS. Both groups were compared as regards the presence of PFI. Results: Peripilar sign was present in 50% of the 100 studied cases. No significant difference existed between those with and those without PPS as regards PFI. Peripilar sign was significantly more encountered in patients with skin type III (p=0.001). Its absence was significantly associated with lower interpretability of yellow dots (p<0.001) and their scores were significantly positively correlated (r=0.498, p<0.001). Peripilar sign was significantly associated with absent melanophages histopathologically (p=0.011). Conclusion: Peripilar sign as a trichoscopic sign in AGA does not reflect PFI. It represents a dark color more encountered in patients with lighter skin types. This can be explained by the increased contrast between the dark PPS and the lighter surrounding skin in lighter skin types. Further studies using melanocyte markers and Masson Fontana's stain are needed to further verify the cause of this peri-follicular dark color.

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Section: Discussionmentioning

confidence: 99%

Peripilar Sign in Androgenetic Alopecia: Does It Really Indicate Peripilar Infiltrate?

Abdalla,

Bosseila,

R.E. Abdel-Halim

et al. 2024

Dermatol Pract Concept

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Azathioprine-Induced Anagen Effluvium: A Case Series of Three Cases

Supekar,

Chopkar,

Gawali

et al. 2024

VJIM

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Azathioprine is a commonly used drug in dermatology for immunobullous diseases, vitiligo, and lichen planus alopecia areata. Azathioprine is rarely known to cause the acute onset of anagen effluvium (AE) that may precede myelosuppression associated with it. We report a series of three cases of azathioprine-induced AE. All three of our cases were females who were treated with azathioprine for non-dermatological conditions such as neuromyelitis optica, idiopathic thrombocytopenia, and optic neuritis. We report this series mainly due to its rarity.

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A Compendium of Common Signs in Dermoscopy, Trichoscopy, and Onychoscopy

Bose

Khandare

Kulkarni³

et al. 2023

Clinical Dermatology Review

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Epiluminescence microscopy, also known as dermoscopy (or dermatoscopy), is a noninvasive tool which helps in identifying features which may not be visible to the unaided eye. Dermoscopic signs in dermatology, trichology, and onychology are evolving concepts for ease in diagnosis of certain dermatological disorders. Although all these signs have been published in different articles and texts as a scattered information, this article intends to consolidate the pertinent signs and create an easy reference for dermatologists in order to establish prompt diagnosis during their busy schedules.

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Trichoscopy in anagen effluvium: Extensive peripilar sign

Cited by 3 publications

References 7 publications

Peripilar Sign in Androgenetic Alopecia: Does It Really Indicate Peripilar Infiltrate?

Peripilar Sign in Androgenetic Alopecia: Does It Really Indicate Peripilar Infiltrate?

Azathioprine-Induced Anagen Effluvium: A Case Series of Three Cases

A Compendium of Common Signs in Dermoscopy, Trichoscopy, and Onychoscopy

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