Trichosporon inkin and Trichosporon mucoides as unusual causes of white piedra of scalp hair

Tendolkar, U; Shinde, Alka; Baveja, Sujata; Dhurat, Rachita; Phiske, Meghana

doi:10.4103/0378-6323.136896

Cited by 12 publications

(5 citation statements)

References 7 publications

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“…A case of white piedra of scalp due to T. inkin was earlier reported from our centre . Literature search revealed that two cases of white piedra and a case of fungal rhinosinusitis due to T. inkin have been reported from India . Isolation of this species from blood has never been reported before.…”

Section: Discussionmentioning

confidence: 95%

Molecular characterisation and antifungal susceptibility of clinical Trichosporon isolates in India

Rastogi

Honnavar

Rudramurthy

et al. 2016

Mycoses

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In Asian countries, Trichosporon infection is a well-known disease in Japan. In India, the infection is increasingly recognised. The study was conducted to characterise the clinical Trichosporon isolates from India by phenotypic and molecular techniques. A total of 31 Trichosporon clinical isolates, recovered from patients of 14 hospitals across India were sequenced (ITS and IGS1 regions of rDNA). In vitro drug susceptibility testing of the isolates was performed against amphotericin-B, fluconazole, itraconazole, voriconazole and posaconazole. IGS1, rather than ITS sequences, correctly identified the isolates: Trichosporon asahii, 20; Trichosporon ovoides, 3; Trichosporon inkin, 2; Trichosporon asteroides, 1; Trichosporon mucoides, 1; Trichosporon loubieri, 1; Trichosporon debeurmannianum, 1; and Trichosporon dermatis, 1. Trichosporon asahii genotype III was the most common type, followed by genotype I and VII. Both these targets did not help to identify one Trichosporon to the species level. Trichosporon debeurmannianum, T. dermatis and T. asteroides were isolated for the first time from a human disease in India. The minimum inhibitory concentrations for voriconazole and posaconazole were within effective range. The study highlights the presence of wide range of Trichosporon species causing infection in India. Voriconazole or posaconazole may be the better drugs to treat such patients.

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Section: Discussionmentioning

confidence: 95%

Molecular characterisation and antifungal susceptibility of clinical Trichosporon isolates in India

Rastogi

Honnavar

Rudramurthy

et al. 2016

Mycoses

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“…Other series indicate that the main agent of WP of the head is T. ovoides and that T. inkin predominates in inguinal and scrotal hair [2, 4, 6, 27]. However, in recent reports it is mentioned that in most of the cases identified by molecular biology or proteomics, the predominant species is T. inkin [1, 7, 10, 19, 21, 27-31]. In our series, T. inkin was isolated in 78% of the cases and to a lesser extent T. cutaneum and T. ovoides .…”

Section: Discussionmentioning

confidence: 99%

White Piedra: Clinical, Mycological, and Therapeutic Experience of Fourteen Cases

Bonifáz¹,

Tirado‐Sánchez²,

Santibáñez³

et al. 2018

Skin Appendage Disord

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Background: White piedra (WP) is an asymptomatic superficial mycosis that affects the hair stems, forming whitish nodules caused by various species of the genus Trichosporon. Objective: To present a case series of WP of the head, its epidemiological data, as well as clinical, mycological, and therapeutic experience. Methods: We conducted a 12-year retrospective and observational study of WP cases tested by dermoscopy, mycological study, and the identification of species through morphology, biochemistry, and proteomics (matrix-assisted laser desorption/ionization time-of-flight mass spectrometry). The treatment was based on ketoconazole shampoo as well as keratolytics. Results: We included 14 cases of WP, all located in the head and 1 case with both head and scrotum affected. Nine cases (64.3%) presented in children aged < 15 years. The majority of the cases (13/14, 92.8%) were women. Two cases were associated with hyperkeratosis and intertrigo. Most patients had long hair and excessive moisture. In all cases hair nodules were observed and Trichosporon inkin (11/14, 78.6%) was usually isolated. Eleven cases (78.6%) were cured by administering 2% ketoconazole shampoo. Conclusion: WP was observed in school-age girls. The diagnosis was based on the observation of hair nodules and its main etiologic agent was T. inkin, with good response to treatment in most cases.

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“…The most distinctive feature of this mycosis is the production of white‐brown nodules adhered to the hair shaft that may easily be detached, in contrast with black piedra nodules . Despite awareness of white piedra in the medical field since the 19th century , there is little knowledge about its mechanisms of infection in humans . Furthermore, it may occur more frequently than current estimates report, especially in tropical countries where it is believed that underdiagnosis occurs .…”

Section: Introductionmentioning

confidence: 99%

Experimental white piedra: a robust approach to ultrastructural analysis, scanning electron microscopy and etiological discoveries

Inácio

Rocha

Barbosa

et al. 2015

Experimental Dermatology

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White piedra is a fungal infection characterized by nodules comprised of Trichosporon species and restricted to the extrafollicular portion of the hair shaft. The diagnosis is based on clinical and mycological characteristics, and must be confirmed with a precise identification of the etiological agent. This research aimed to develop an in vitro infection model of white piedra and analyze its morphological and ultra-structural aspects. In the process, hair infection was induced using eight isolates of the genus Trichosporon maintained in the Culture Collection Micoteca URM. The ITS and IGS1 regions were sequenced for taxonomic confirmation. Scanning Electron Microscope (SEM) was performed at the Strategic Center for Northeast Technologies (CETENE). The scanning electron microscope was equipped with an Energy Dispersion Spectrometer (EDS). The Trichosporon isolates were identified as Trichosporon asahii (6) and Trichosporon montevideense (2) by internal transcript spacer (ITS) region and intergenic spacer 1 region (IGS1) sequencing. All eight strains were used to induce the in vitro hair infection, and nodules formed after the incubation period. Temperature variations and high humidity were not observed to be related to the development of this hair disease. The main chemical constituents detected in the nodules were carbon, nitrogen and oxygen, as well as a low level of sulfur. The absence of calcium, combined with the low level of sulfur, might explain the soft nature of the white piedra nodules. This study demonstrated that several Trichosporon species may be responsible for causing white piedra.

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Trichosporon inkin and Trichosporon mucoides as unusual causes of white piedra of scalp hair

Cited by 12 publications

References 7 publications

Molecular characterisation and antifungal susceptibility of clinical Trichosporon isolates in India

Molecular characterisation and antifungal susceptibility of clinical Trichosporon isolates in India

White Piedra: Clinical, Mycological, and Therapeutic Experience of Fourteen Cases

Experimental white piedra: a robust approach to ultrastructural analysis, scanning electron microscopy and etiological discoveries

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