Trichothecin inhibits invasion and metastasis of colon carcinoma associating with SCD-1-mediated metabolite alteration

Liao, Chaoliang; Li, Min; Li, Xiang; Li, Namei; Zhao, Xu; Wang, Xiaoyi; Song, Yawen; Quan, Jing; Cheng, Chunxia; Liu, Ji‐Kai; Bode, Ann M.; Cao, Yang

doi:10.1016/j.bbalip.2019.158540

Cited by 22 publications

(13 citation statements)

References 62 publications

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“…Lipid metabolic abnormalities have been attracting increasing interest not only because the lipid plays a critical role in the survival of cancer cells but also because there are accumulating studies indicating that lipid metabolic alterations are a driving force in the development and progression of multiple cancers including HCC[ 9 , 23 ]. Growing evidence suggests that increased de novo synthesis of lipids and desaturation are responsible for HCC tumorigenesis and progression[ 24 ].…”

Section: Metabolic Alterations In Hccmentioning

confidence: 99%

Characterization of metabolic landscape in hepatocellular carcinoma

Xue

Jiang

et al. 2021

WJGO

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Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide, accounting for approximately 75%-85% of primary liver cancers. Metabolic alterations have been labeled as an emerging hallmark of tumors. Specially, the last decades have registered a significant improvement in our understanding of the role of metabolism in driving the carcinogenesis and progression of HCC. In this paper, we provide a review of recent studies that investigated the metabolic traits of HCC with a specific focus on three common metabolic alterations involving glycolysis, lipid metabolism, and glutamine addiction which have been gaining much attention in the field of HCC. Next, we describe some representative diagnostic markers or tools, and promising treatment agents that are proposed on the basis of the aforementioned metabolic alterations for HCC. Finally, we present some challenges and directions that may promisingly speed up the process of developing objective diagnostic markers and therapeutic options underlying HCC. Specifically, we recommend future investigations to carefully take into account the influence of heterogeneity, control for study-specific confounds, and invite the validation of existing biomarkers.

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Section: Metabolic Alterations In Hccmentioning

confidence: 99%

Characterization of metabolic landscape in hepatocellular carcinoma

Xue

Jiang

et al. 2021

WJGO

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“…As the critical enzyme in FA metabolism, SCD is responsible for the conversion of saturated FAs to unsaturated FAs, and oleic acid is one of the major products [33]. Researchers found that gut-speci c SCD-1 activity is necessary to control intestinal epithelial in ammation and synthetize oleate, and that dietary oleic acid provides protection against intestinal in ammation in vivo [34]. Thus, FP intervention upregulated Plin1, Plin4, Adipoq, Angptl4 and Scd to regulate and attenuate in ammation.…”

Section: Fp Intervention Promoted Lipid Metabolism Of the Colonic Epimentioning

confidence: 99%

Flaxseed Polysaccharide Altering Colonic Gene Expression of Lipid Metabolism and Energy Metabolism in Obese Rat

Lin¹,

Qi²,

Zhang³

et al. 2020

Preprint

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BackgroundObesity is one of the most serious public health challenges. Recently, we found that flaxseed polysaccharide (FP) had an anti-obesity effect through promoting lipid metabolism, inducing satiety and regulating gut microbiota, but how FP promote lipid metabolism through altering the colonic epithelial cells remains to be elucidated. In this study, a transcriptome study was performed to investigate the effect of FP altering the gene expression of colonic epithelial cells in an obese rat model. ResultsThe transcriptome analysis showed that 3,785 genes were differentially expressed after FP intervention in colonic epithelial cells, including 374 down-regulated and 3,411 up-regulated genes. Through KEGG analysis, we found out three classical pathways related to lipid metabolism and energy metabolism, including PPAR signaling pathway, nitrogen metabolism and oxidative phosphorylation (OXPHOS). Moreover, qRT-PCR results showed consistent expression trends of differential genes with transcriptome analysis. ConclusionsThe anti-obesity effect of FP may be achieved by regulating the expression of lipid metabolism- and energy metabolism-related proteins acting on the PPAR (peroxisome proliferator-activated receptor) signaling pathway, nitrogen metabolism and OXPHOS pathway in vivo.

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“…Previous studies showed that different expression genes associated with fatty acid metabolic pathways might take part in the development and metastasis of CRC 11 , 12 . The enzyme acyl-CoA dehydrogenase short-chain (ACADS) catalyzes the first step of the mitochondrial fatty acid beta-oxidation, which is supposed to have a role in the carcinogenesis of CRC.…”

Section: Introductionmentioning

confidence: 99%

Integrated Analysis of Expression and Prognostic Values of Acyl-CoA Dehydrogenase short-chain in Colorectal Cancer

Yan

Chen

et al. 2021

Int. J. Med. Sci.

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Background: Acyl-CoA dehydrogenase short-chain (ACADS) is a crucial enzyme in the fatty acid metabolism pathway located in mitochondria. However, the expression level and prognostic value of ACADS in colorectal cancer (CRC) remain unclear. Methods: The mRNA and protein expression data of ACADS was obtained from The Cancer Genome Atlas (TCGA), Clinical Proteomic Tumor Analysis Consortium (CPTAC), and Oncomine. Prognostic values of ACADS were calculated using Kaplan-Meier survival analysis. Correlations between ACADS and immune infiltration were estimated using TIMER, CIBERSORT, EPIC, quanTIseq, and xCell. The UALCAN and MEXPRESS databases were utilized for Methylation analysis. The co-expression analysis based on mRNA expression and interaction network of ACADS were performed via several online tools. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis on ACADS co-expressed genes were performed using the Metascape. Results: The expression analysis demonstrated that ACADS was down-regulated in CRC tissues compared with paired normal tissue. Expression of ACADS was found to be significantly associated with clinical cancer stages and the consensus molecular subgroups (CMS) constituent ratio in CRC patients. Besides, lower ACADS expression was found to predict poor prognosis and be significantly associated with common immune checkpoint genes and MMR genes in CRC. ACADS expression levels were positively related to B cells, CD4 + T cells, CD8 + T cells, M1 macrophages, neutrophils, and Tregs, while negatively correlated with M0 macrophages, M2 macrophages. The methylation level of ACADS in normal tissues was significantly higher than that in tumor tissues, and several methylation sites were identified. The enrichment analysis suggested the co-expressed genes mainly enriched in cell mitochondrial metabolism. Conclusions: The present study provided multilevel evidences for expression of ACADS in CRC and the function of ACADS in prognostic prediction, immune infiltration, and methylation. ACADS might have the potential as the novel biomarker and therapeutic target in CRC patients.

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Trichothecin inhibits invasion and metastasis of colon carcinoma associating with SCD-1-mediated metabolite alteration

Cited by 22 publications

References 62 publications

Characterization of metabolic landscape in hepatocellular carcinoma

Characterization of metabolic landscape in hepatocellular carcinoma

Flaxseed Polysaccharide Altering Colonic Gene Expression of Lipid Metabolism and Energy Metabolism in Obese Rat

Integrated Analysis of Expression and Prognostic Values of Acyl-CoA Dehydrogenase short-chain in Colorectal Cancer

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