Trichotillomania: Neurobiology and treatment

Chamberlain, Samuel R.; Odlaug, Brian L.; Boulougouris, Vasileios; Fineberg, Naomi; Grant, Jon E.

doi:10.1016/j.neubiorev.2009.02.002

Cited by 107 publications

(98 citation statements)

References 102 publications

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“…Indeed premenstrual, pregnancy and post-partum periods were associated with an increased risk of onset and exacerbation of OCD (Abramowitz et al, 2003;Labad et al, 2005;Vulink et al, 2006) and trichotillomania (Chamberlain et al, 2009;Duke et al, 2010). This is in line with evidence implicating the modulation of compulsive behavior by ovarian hormones in three animal models of OCD: 8-OHDPAT-induced decreased alternation in rats, marble burying in mice and rats and signal attenuation in rats.…”

Section: Discussionsupporting

confidence: 82%

Adrenal activity and anxiety-like behavior in fur-chewing chinchillas (Chinchilla lanigera)

Ponzio

Monfort

Busso

et al. 2012

Hormones and Behavior

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Section: Discussionsupporting

confidence: 82%

Adrenal activity and anxiety-like behavior in fur-chewing chinchillas (Chinchilla lanigera)

Ponzio

Monfort

Busso

et al. 2012

Hormones and Behavior

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“…For example, one study of 110 university students with and without skin picking found higher rates of hair pulling in the picking group (Snorrason, Smári & Ólafsson, 2011). This comorbidity research, in addition to an extensive body of phenomenology research (Chamberlain et al, 2009;Grant et al, 2012), has generally supported the claim that hair pulling and skin picking share clinical and probably neurobiological similarities. Based on this research, we would have expected higher rates of picking in the hair pulling group.…”

Section: Discussionmentioning

confidence: 96%

“…Yet, the results may suggest that hair pulling among males reflect a different neurobiology than in females. They also raise questions about the degree of impulsivity and compulsivity underlying hair pulling behavior (Chamberlain, Odlaug, Boulougouris, Fineberg & Grant, 2009) and whether and to what extent gender is associated with the domains of compulsivity and impulsivity. Gender may perhaps play a role in the heterogeneous presentation seen in individuals with hair pulling.…”

Section: Discussionmentioning

confidence: 99%

Impulse control disorders in non-treatment seeking hair pullers

Schreiber¹,

Lust²,

Odlaug³

et al. 2013

Journal of Behavioral Addictions

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Background and aims:Hair pulling is a common body focused repetitive behavior. The purpose of this paper is to examine the prevalence of impulse control disorders (as defined in DSM-IV-TR) in a non-treatment seeking sample of hair pullers. Methods: 1,717 college students with (n = 44) and without (n = 1673) hair pulling completed a mental health survey. The college students were sent an online survey assessing hair pulling behavior and other impulse control disorders using the Minnesota Impulsive Disorders Interview. Results: Students with hair pulling were significantly more likely to have a co-occurring impulse control disorder (20.5% vs. 8.9%, p = 0.009, OR = 2.71, CI = 1.28-5.75) and were significantly more likely to meet criteria for compulsive buying, compulsive sexual behavior and intermittent explosive disorder than students without hair pulling. Differences seemed to be moderated by the male gender among students with hair pulling. Discussion and conclusions: Hair pulling is often comorbid with another impulse control disorder, which suggests that elements of impulsivity may be important in our understanding of hair pulling. Furthermore, gender may moderate impulse control comorbidity in hair pulling disorder.

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“…In addition, rates of trichotillomania are increased in first-degree relatives of individuals with OCD [12]. Trichotillomania also shares a strong similarity with OCD in terms of underlying abnormalities in corticostriatal pathways as well as some associated impairments in the cognitive abilities linked to the integrity of these brain structures [18,49]. However, in contrast to OCD, trichotillomania is not consistently responsive to serotonin-based pharmacotherapy; it also shows a better response to an non-selective serotonin reuptake inhibitor clomipramine than to SSRIs [50].…”

Section: Trichotillomania and Skin Picking Disordermentioning

confidence: 99%

From anxiety to compulsivity – a review of changes to OCD classification in DSM-5 and ICD-11

Krzanowska¹,

Kuleta²

2017

Arch Psych Psych

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SummaryObsessive-compulsive disorder (OCD) is no longer classified as an anxiety disorder in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). It has become a flagship disorder of the new category of Obsessive Compulsive and Related Disorders (OCRDs) -a group of five disorders linked together by the core symptom of repetitive thoughts and behaviors and phenomenological and neurobiological similarity to OCD. Body dysmorphic disorder, hoarding disorder, trichotillomania, and skin picking disorder are the other disorders included in this group. In the upcoming eleventh edition of the International Classification of Diseases (ICD)-11, the World Health Organization (WHO) is planning to introduce similar changes to its own classification of OCD, further recommending the inclusion of olfactory reference disorder and hypochondriasis, in addition to the disorders listed in the DSM-5. In this article, we will review the classifications of OCD and OCDRs in the DSM-5 and the upcoming ICD-11, as well as describe the rationale and research leading to the creation of this new class of disorders.

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Trichotillomania: Neurobiology and treatment

Cited by 107 publications

References 102 publications

Adrenal activity and anxiety-like behavior in fur-chewing chinchillas (Chinchilla lanigera)

Adrenal activity and anxiety-like behavior in fur-chewing chinchillas (Chinchilla lanigera)

Impulse control disorders in non-treatment seeking hair pullers

From anxiety to compulsivity – a review of changes to OCD classification in DSM-5 and ICD-11

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