A 2-year-old female Vigova duck weighing 3.2 kg was presented to the Department of Veterinary Pathology for a postmortem with an enlarged abdomen and swelling of the plantar aspect of the feet. Gross examination revealed a severely enlarged pale pink liver weighing 440 g, occupying almost the entire length of the abdominal cavity. Microscopically, the liver revealed extensive deposition of homogenous, eosinophilic material in the hepatic parenchyma, replacing the hepatocytes, along with infi ltration of mononuclear cells. The homogenous, eosinophilic materials fi lled and expanded the interstitium of the spleen, kidney, intestine, and ovary, in addition to the liver. The homogenous, eosinophilic material was confi rmed to be amyloid with Congo red stain. Further, Masson's trichrome staining revealed the presence of fi brosis along with amyloid deposition. Culture from the necrosed region of the foot revealed bunches of Gram-positive cocci, indicating Staphylococcus organism. Based on gross, histopathological, and microbiological examination, the present case was diagnosed as systemic amyloidosis with fi brosis secondary to ulcerative pododermatitis in a Vigova duck.