Trichuris suis:Thiol Protease Activity from Adult Worms

Therapeutic potential of larval excretory/secretory proteins of the pig whipwormTrichuris suisin allergic disease

“…Excretory/secretory products from adult‐stage T. suis have previously been shown to have enzymatic activities with homology to other known immunomodulators from related parasitic nematodes . In addition, the genome and transcriptome of Trichuris suis and its murine counterpart T. muris were recently elegantly defined .…”

Metronidazole—but not IL-10 or prednisolone—rescues Trichuris muris infected C57BL/6 IL-10 deficient mice from severe disease

“…Larval and adult stages burrow into the host's colonic epithelium forming syncytial tunnels and condition the environment with several well characterized excretory-secretory products (ESP). Trichuris ESP aid the worm both in burrowing into the host's colonic epithelium by breaking down tight junctions (Abner et al, 2002) and in feeding due to several enzymatic activities (Abner et al, 2002;Hill et al, 1993;Hill and Sakanari, 1997). A 42 kDa zinc metalloprotease likely functions to provide nutrition for the worms through http://dx.doi.org/10.1016/j.vetpar.2015.07.038 0304-4017/© 2015 Elsevier B.V. All rights reserved.…”

Coprological Survey of Parasitic Infections in Pigs and Cattle in Slaughterhouse in Osaka, Japan

“…Although it is reported that sever T. suis infection showed serious symptoms, such as anemia, weight loss, anorexia, mucohemorrhagic diarrhea and death [12]. In a previous survey in Japan, Fujiwara et al [9] reported that the prevalence in pigs which showed clinical symptoms by T. suis infection was <12.8%.…”