Tricin promoted ATG-7 dependent autophagic degradation of α-synuclein and dopamine release for improving cognitive and motor deficits in Parkinson's disease

Wang, Xingxia; Hu, Wei; Qu, Liqun; Wang, Jian; Wu, Anguo; Lo, Hang Hong; Ng, Jerome P. L.; Tang, Yong; Yun, Xiaoyun; Wu, Jian; Wong, Vincent Kam Wai; Chung, Sookja K.; Wang, Linna; Luo, Weidan; Xiang, Jianbin; Law, Betty Yuen Kwan

doi:10.1016/j.phrs.2023.106874

Cited by 7 publications

(2 citation statements)

References 83 publications

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“… 80 A recent study has shown that tricin, a natural flavonoid, can improve autophagy and ATG-7-dependent clearance of α-syn via an AMPK/mTOR pathway. 81 …”

Section: Effect Of Ampk On Macroautophagymentioning

confidence: 99%

“…80 A recent study has shown that tricin, a natural flavonoid, can improve autophagy and ATG-7-dependent clearance of α-syn via an AMPK/mTOR pathway. 81 There are three main ways to remove α-syn from neurons: the ubiquitin-proteasome system (UPS), chaperone-mediated autophagy (CMA), and macroautophagy. 82 Removing α-syn oligomers requires macroautophagy-mediated degradation because UPS and CMA are ineffective.…”

Section: Effect Of Ampk On Macroautophagymentioning

confidence: 99%

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AMPK signaling pathway as a potential therapeutic target for Parkinson's disease

Athari,

Farajdokht,

Keyhanmanesh

et al. 2023

Adv Pharm Bull

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Parkinson's disease (PD) is the second most common neurodegenerative disease caused by the loss of dopaminergic neurons. Genetic factors, inflammatory responses, oxidative stress, metabolic disorders, cytotoxic factors, and mitochondrial dysfunction are all involved in neuronal death in neurodegenerative diseases. The risk of PD can be higher in aging individuals due to decreased mitochondrial function, energy metabolism, and AMP-activated protein kinase (AMPK) function. The potential of AMPK to regulate neurodegenerative disorders lies in its ability to enhance antioxidant capacity, reduce oxidative stress, improve mitochondrial function, decrease mitophagy and macroautophagy, and inhibit inflammation. In addition, it has been shown that modulating the catalytic activity of AMPK can protect the nervous system. This article reviews the mechanisms by which AMPK activation can modulate PD.

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“… 80 A recent study has shown that tricin, a natural flavonoid, can improve autophagy and ATG-7-dependent clearance of α-syn via an AMPK/mTOR pathway. 81 …”

Section: Effect Of Ampk On Macroautophagymentioning

confidence: 99%

Section: Effect Of Ampk On Macroautophagymentioning

confidence: 99%

AMPK signaling pathway as a potential therapeutic target for Parkinson's disease

Athari,

Farajdokht,

Keyhanmanesh

et al. 2023

Adv Pharm Bull

View full text Add to dashboard Cite

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Programmed cell death: molecular mechanisms, biological functions, diseases, and therapeutic targets

Qian,

Long,

Tan

et al. 2024

MedComm

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Programmed cell death represents a precisely regulated and active cellular demise, governed by a complex network of specific genes and proteins. The identification of multiple forms of programmed cell death has significantly advanced the understanding of its intricate mechanisms, as demonstrated in recent studies. A thorough grasp of these processes is essential across various biological disciplines and in the study of diseases. Nonetheless, despite notable progress, the exploration of the relationship between programmed cell death and disease, as well as its clinical application, are still in a nascent stage. Therefore, further exploration of programmed cell death and the development of corresponding therapeutic methods and strategies holds substantial potential. Our review provides a detailed examination of the primary mechanisms behind apoptosis, autophagy, necroptosis, pyroptosis, and ferroptosis. Following this, the discussion delves into biological functions and diseases associated dysregulated programmed cell death. Finally, we highlight existing and potential therapeutic targets and strategies focused on cancers and neurodegenerative diseases. This review aims to summarize the latest insights on programmed cell death from mechanisms to diseases and provides a more reliable approach for clinical transformation.

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The potential therapeutic strategy in combating neurodegenerative diseases: Focusing on natural products

Gao,

Yang,

Dong

et al. 2024

Pharmacology & Therapeutics

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Tricin promoted ATG-7 dependent autophagic degradation of α-synuclein and dopamine release for improving cognitive and motor deficits in Parkinson's disease

Cited by 7 publications

References 83 publications

AMPK signaling pathway as a potential therapeutic target for Parkinson's disease

AMPK signaling pathway as a potential therapeutic target for Parkinson's disease

Programmed cell death: molecular mechanisms, biological functions, diseases, and therapeutic targets

The potential therapeutic strategy in combating neurodegenerative diseases: Focusing on natural products

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