Tricking the balance: NK cells in anti-cancer immunity

Pahl, Jens; Cerwenka, Adelheid

doi:10.1016/j.imbio.2015.07.012

Cited by 171 publications

(155 citation statements)

References 167 publications

(168 reference statements)

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Section: Infiltration Of M2 Macrophagesmentioning

confidence: 99%

“…NK cells are regulated by a complex balance of inhibitory and stimulatory signals [80]. Inhibitory killer Ig-like receptors expressed on NK cells bind MHC-I molecules and prevent NK-mediated killing of normal tissues [80]. Stimulation occurs primarily through MHC class I-related chain -A and -B (MICA/MICB) binding of NKG2A and NKG2D expressed on NK cells [80].…”

Section: Infiltration Of M2 Macrophagesmentioning

confidence: 99%

“…Inhibitory killer Ig-like receptors expressed on NK cells bind MHC-I molecules and prevent NK-mediated killing of normal tissues [80]. Stimulation occurs primarily through MHC class I-related chain -A and -B (MICA/MICB) binding of NKG2A and NKG2D expressed on NK cells [80]. Cancer cells have been shown to evade NK cell activation by cleaving surface MICA/B into a soluble form, which transiently activates NK cells nonspecifically, but ultimately causes inhibition by inducing downregulation of NKG2D (Figure 2: process 'H') [80].…”

Section: Infiltration Of M2 Macrophagesmentioning

confidence: 99%

“…Stimulation occurs primarily through MHC class I-related chain -A and -B (MICA/MICB) binding of NKG2A and NKG2D expressed on NK cells [80]. Cancer cells have been shown to evade NK cell activation by cleaving surface MICA/B into a soluble form, which transiently activates NK cells nonspecifically, but ultimately causes inhibition by inducing downregulation of NKG2D (Figure 2: process 'H') [80]. The presence of soluble MICA in patient sera has been associated with poor outcome in some cancer types [80] but has not been reported in MCC.…”

Section: Infiltration Of M2 Macrophagesmentioning

confidence: 99%

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Rationale For Immune-Based Therapies in Merkel Polyomavirus-Positive and -Negative Merkel Cell Carcinomas

Vandeven

Nghiem

2016

Immunotherapy

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Merkel cell carcinoma (MCC) is a rare but often deadly skin cancer that is typically caused by the Merkel cell polyomavirus (MCPyV). Polyomavirus T-antigen oncoproteins are persistently expressed in virus-positive MCCs (∼80% of cases), while remarkably high numbers of tumor-associated neoantigens are detected in virusnegative MCCs, suggesting that both MCC subsets may be immunogenic. Here we review mechanisms by which these immunogenic tumors evade multiple levels of host immunity. Additionally, we summarize the exciting potential of diverse immunebased approaches to treat MCC. In particular, agents blocking the PD-1 axis have yielded strikingly high response rates in MCC as compared with other solid tumors, highlighting the potential for immune-mediated treatment of this disease.

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Section: Infiltration Of M2 Macrophagesmentioning

confidence: 99%

Section: Infiltration Of M2 Macrophagesmentioning

confidence: 99%

Section: Infiltration Of M2 Macrophagesmentioning

confidence: 99%

Section: Infiltration Of M2 Macrophagesmentioning

confidence: 99%

See 2 more Smart Citations

Rationale For Immune-Based Therapies in Merkel Polyomavirus-Positive and -Negative Merkel Cell Carcinomas

Vandeven

Nghiem

2016

Immunotherapy

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“…15,16 NK cells, a lymphocytic subset of the innate immune system, 17 are involved in the first line of defense against infected and malignant cells. 18,19 In rats, NK cell activity was significantly attenuated by stress and by surgical procedures (laparotomy), which subsequently also led to an increase in the retention of inoculated tumor cells in these animals. 20 In humans undergoing surgery for breast, hepatocellular, or pulmonary carcinoma, a reduction of NK cell activity has also been observed.…”

Section: Anti-inflammatory Effects Of Local Anesthetics Potentially Amentioning

confidence: 99%

Do Amide Local Anesthetics Play a Therapeutic Role in the Perioperative Management of Cancer Patients?

Piegeler¹,

Hollmann

Borgeat

et al. 2016

International Anesthesiology Clinics

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pH‐Responsive and Therapeutic Liposomes for Enhanced High‐Intensity Focused Ultrasound Imaging and Therapy in Gynecologic Malignancies

Zhang,

Gao,

Yuan

et al. 2024

Adv Funct Materials

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Clinical evidence suggests that high‐intensity focused ultrasound (HIFU) is emerging as an increasingly viable non‐invasive treatment for various gynecological diseases, demonstrating both high safety and effectiveness. Nevertheless, HIFU presents challenges in terms of energy dissipation and prolonged treatment time during the therapeutic process. In this study, liposomes containing ammonium bicarbonate (NH4HCO3) and paclitaxel (PTX), a first‐line chemotherapy drug, are utilized to enhance HIFU imaging and therapy. During HIFU treatment, the NH4HCO3 and PTX‐loaded liposomes (PTN@Lip) can release CO2 and NH3 in the tumor's acidic environment. These not only improve HIFU imaging but also regulate the tumor's acidic environment, thereby enhancing the uptake of PTX by tumor cells. Notably, the implementation of PTN@Lip and HIFU activates the immune system, leading to tumor inhibition or even elimination ultimately. This approach has the potential to address existing clinical treatment challenges and lay the groundwork for new directions in the treatment of gynecological tumors.

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Tricking the balance: NK cells in anti-cancer immunity

Cited by 171 publications

References 167 publications

Rationale For Immune-Based Therapies in Merkel Polyomavirus-Positive and -Negative Merkel Cell Carcinomas

Rationale For Immune-Based Therapies in Merkel Polyomavirus-Positive and -Negative Merkel Cell Carcinomas

Do Amide Local Anesthetics Play a Therapeutic Role in the Perioperative Management of Cancer Patients?

pH‐Responsive and Therapeutic Liposomes for Enhanced High‐Intensity Focused Ultrasound Imaging and Therapy in Gynecologic Malignancies

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