Triclonal gammopathy in a patient with AIDS.

Ray, Roshmi; Schotters, S B

doi:10.1093/clinchem/32.10.2000

Cited by 10 publications

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“…Triclonal gammopathy was reported in a patient with plasma cell dyscrasia who subsequently developed acquired immunodeficiency syndrome (AIDS) (51). Grosbois et al.…”

Section: Variants Of Mgusmentioning

confidence: 99%

MONOCLONAL GAMMOPATHIES OF UNDETERMINED SIGNIFICANCE

Kyle

Rajkumar

2002

Rev Clin Exp Hematol

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The term 'monoclonal gammopathy of undetermined significance' denotes the presence of a monoclonal protein in patients without evidence of multiple myeloma, macroglobulinemia, amyloidosis or related plasma cell proliferative disorders. The disorder has been found in approximately 3% of persons older than 70 years and in approximately 1% of persons older than 50 years. A population-based study included 1384 patients from south-eastern Minnesota who had the disorder diagnosed at the Mayo Clinic from 1960 through 1994. Risk of progression was about 1% per year, but patients were at risk of progression even after 25 years or more of stable monoclonal gammopathy of undetermined significance. The risk for development of multiple myeloma was increased 25-fold; the risk of macroglobulinemia, 46-fold; and the risk of primary amyloidosis, 8.4-fold. Concentration and type of monoclonal protein were the only independent predictors of progression. The presence of a urine monoclonal protein and the reduction of one or more uninvolved immunoglobulins were not risk factors for progression. Monoclonal gammopathy of undetermined significance may be associated with various disorders, including lymphoproliferative diseases, leukemia, von Willebrand disease, connective tissue diseases and neurologic disorders.

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“…Triclonal gammopathy was reported in a patient with plasma cell dyscrasia who subsequently developed acquired immunodeficiency syndrome (AIDS) (51). Grosbois et al.…”

Section: Variants Of Mgusmentioning

confidence: 99%

MONOCLONAL GAMMOPATHIES OF UNDETERMINED SIGNIFICANCE

Kyle

Rajkumar

2002

Rev Clin Exp Hematol

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Five monoclonal proteins in a patient with chronic myelomonocytic leukemia

et al. 1992

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He presented to our institute wlth fever and general malaise in July 1990. Complete blood count showed 9.6 gidl, WBC 1.7 x 109/L, and platelets 85 X IO' iL. Bone marrow aspirate showed hypercellularity with 69.2% atypical promyelocytes with Auer rods. Cytochemical examination revealed that leukemic cells in the bone marrow were highly positive for peroxidase stain. Chromosomal analysis of marrow cells by G-banding revealed normal karyotype. lmrnunophenotyping of the leukemic cells was CD13 (54.8%) and CD33 (57.0%) positive. Thus, the patient was diagnosed as having APL. He was treated with behenoyl cytosine arabinoside, daunorubicin, 6-niercaptopurine, and prednisolone. A complete remission was achieved after I month, The patient remains in complete remission in June 1991.DM is a rare and severe disorder characterized by an inflammatory myopathy and typical cutaneous lesions [3]. Some reports have noted that patients with DM develop malignant neoplastic disease, and that the most common tumors associated with DM are those of the lungs. uterus, ovary, breast. prostate, and gastrointestinal tract 141. However, it is very unusual that DM was associated with APL and moreover with seminoma. T o our knowledge, this association has not been previously described. There are various possible causes for the APL seen in our patient. In this case, seminoma was treated with cytotoxic drugs. It is possible that APL occurred as a therapy-related leukemia. Therapy-related leukemias are known to occur as a side effect of treatment with cytotoxic drugs, particularly alkylating agents IS]. Moreover, therapy-related leukemias commonly accompany cytogenetic abnormality and inyelodysplastic changes [6,7]. However. in our patient the clinical presentation and evolution were not typical of therapy-related leukemias. In addition, alkylating agents were not used in this case. Thus, there was little possibility of therapy-related leukemia. Although an abnormal immune mechanism may have caused the APL, we cannot directly demonstrate it. We must also consider the possibility that the association of DM. APL. and seminoma in our patient may have been entirely coincidental.We conclude that awareness of this association may lead to earlier detection of malignancy. and hence to potentially more effective therapy. TOMOHIRO SUGAWARA KAZUYAW ENDO

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Monoclonal Gammopathy of Undetermined Significance

Kyle

Rajkumar

2012

Neoplastic Diseases of the Blood

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Triclonal gammopathy in a patient with AIDS.

Cited by 10 publications

References 0 publications

MONOCLONAL GAMMOPATHIES OF UNDETERMINED SIGNIFICANCE

MONOCLONAL GAMMOPATHIES OF UNDETERMINED SIGNIFICANCE

Five monoclonal proteins in a patient with chronic myelomonocytic leukemia

Monoclonal Gammopathy of Undetermined Significance

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