Tricoumaroylspermidine from rose exhibits inhibitory activity against ethanol-induced apoptosis in HepG2 cells

Zhou, Qian; Wang, Lanxiang; Liu, Bin; Xiao, Jianbo; Cheng, Ka‐Wing; Chen, Feng; Wang, Mingfu

doi:10.1039/d1fo00800e

Cited by 17 publications

(8 citation statements)

References 34 publications

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“…In addition to activities in response to various stresses, phenolamides also exhibit good biological activities. For example, the tri-p-coumaroylspermidine from rose flowers exhibits remarkable hepatoprotective activity [40] , and di-hydrocaffeoylspermine can inhibit Srebp1c and downstream gene expression to inhibit lipid accumulation, inflammation, insulin resistance, and oxidative stress [41] .…”

Section: Discussionmentioning

confidence: 99%

“…The separation was carried out on a Hypersil GOLD C18 column (250 mm × 4.6 mm, 5 µm, Thermo). Elution with solvent A (1% acetic acid) and solvent B (acetonitrile) in a step gradient way at a flow rate of 0.5 mL/ min was carried out as follows: (0-10) min, 5%-12% B; (10)(11)(12)(13)(14)(15) min, 12%-16% B; (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) min, 16%-20% B; (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40) The PPE was analyzed by using an Accurate-Mass Q-TOF LC/MS 6520 equipped with a diode array detector (Agilent Technologies, USA). For MS detection, the column and conditions for the mobile phase gradient were the same as those in HPLC analysis.…”

Section: Identification and Quantification Of Phenols In Ppementioning

confidence: 99%

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Identification of phenolamine in rape bee pollen and its protective effect and mechanism on alcoholic liver injury

Lü,

Xu,

Yang

et al. 2024

Food Science and Human Wellness

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Rape bee pollen has attracted increasing interests for its excellent protective effect against chemical-induced liver injury owing to its abundant polyphenols. This study aims to analyze the types and contents of phenolamides (seldom concerned) in rape bee pollen and their protective mechanism on alcoholic liver disease (ALD). Different from the previous finding that flavonoids are dominant polyphenols in bee pollen polyphenolic extract, our results demonstrated that there are only three flavonoids but 24 phenolamides in the as-prepared rape bee pollen phenolic extract (PPE). In addition, PPE was found to significantly improve the viability (from 54.9% to 84.1%, 89.2%, and 94.0%) of alcohol-induced AML12 cells and alleviate alcohol-induced cell apoptosis (from 28.5% to 22.89%, 22.0%, and 17.4%). To dissect the underlying mechanism for the protective effect of PPE against ALD, the molecular pathway was identified by RNA-seq analysis. Transcriptome data revealed that PPE may protect against ALD by decreasing inflammation, cholesterol, and fatty acid synthesis (P < 0.05). The NIAAA model was used to further evaluate the hepatoprotective effect of PPE in vivo, and the results validated that PPE could alleviate liver injury and hepatic steatosis (from 22.7% to 11.5% and 10.9%) induced by alcohol. As the dominant polyphenols in PPE, phenolamides can be a class of valuable polyphenolic compounds in bee pollen with the potential to alleviate ALD.

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Section: Discussionmentioning

confidence: 99%

Section: Identification and Quantification Of Phenols In Ppementioning

confidence: 99%

Identification of phenolamine in rape bee pollen and its protective effect and mechanism on alcoholic liver injury

Lü,

Xu,

Yang

et al. 2024

Food Science and Human Wellness

View full text Add to dashboard Cite

show abstract

“…Another 200 mL of methanol was used for rinsing during filtration. To determine the amount of each green tea component, a few volumes of green tea extract in methanol were sampled, diluted in methanol, and filtered through a 0.45 µm nylon syringe filter prior to HPLC analysis by using the external calibration method [ 23 ]. Following that, the green tea extract was concentrated under vacuum at 35 ± 1 °C to reach 2 different concentration levels, 0.058 ± 0.001 g (Level 1) and 0.094 ± 0.001 g (Level 2) of EGCG per gram of green tea extract.…”

Section: Methodsmentioning

confidence: 99%

Comparative Study of Sensory and Physicochemical Characteristics of Green-Tea-Fortified Cupcakes upon Air Frying and Oven Baking

Ngan

Wang

et al. 2023

Foods

Self Cite

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The air fryer and the oven are common cooking methods in our daily lives. However, previous investigations of the air fryer were limited to its comparison with deep-fat frying. This study compared the differences between air frying and household oven baking (without a fan or other forced airflow inside) on food quality and physicochemical properties using a cupcake model. Results showed that the oven-baked cupcakes were softer in texture (87.15%), greener in color (6.07%), and lower in weight loss (7.78%) and toxic advanced glycation end products (AGEs, 21.40%) when the heating temperature and duration were the same as oven baking. To improve the sensory characteristics and health value, the cupcakes were fortified with green tea. The differences in texture, color, and level of toxicants between the two cooking methods were diminished after the addition of green tea. Moreover, the chemical profiles of green tea catechins in the green-tea-fortified cupcakes remained similar upon thermal cooking, except that the air-fried cupcakes were lower in gallic acid (GA) but higher in (−)-gallocatechin (GC). Collectively, based on the differences in heating mechanisms, our data indicated that oven baking is a better cooking method suitable to prepare cupcakes than air frying from the perspectives of sensory characteristics and food safety, while green tea additives effectively counter the drawbacks of the air fryer.

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“…Hepatocyte apoptosis is involved in the pathogenesis of alcohol-related liver disease (ALD), so anti-apoptotic extracts are of great importance in the prevention or treatment of ALD. Rosa rugosa extracts were shown to prevent EtOH-induced apoptosis in HepG2 cells via the activation of the AMPK/SIRT1 signaling pathway, revealing the anti-alcohol and hepatoprotective benefits of consuming rose [ 100 ]. The nutrition of the Rosa rugosa flower including vitamin C, flavonoids, and anthocyanins could be well retained by infrared freeze drying [ 101 ].…”

Section: Effect Of Treatmentmentioning

confidence: 99%

Beneficial medicinal effects and material applications of rose

Wang

2024

Heliyon

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Tricoumaroylspermidine from rose exhibits inhibitory activity against ethanol-induced apoptosis in HepG2 cells

Abstract: Hepatocyte apoptosis is involved in the pathogenesis of alcohol-associated liver disease (ALD) and anti-apoptotic agents/extracts are thereby of great potential in the prevention/treatment of ALD. In this study, the protective...

Cited by 17 publications

References 34 publications

Identification of phenolamine in rape bee pollen and its protective effect and mechanism on alcoholic liver injury

Identification of phenolamine in rape bee pollen and its protective effect and mechanism on alcoholic liver injury

Comparative Study of Sensory and Physicochemical Characteristics of Green-Tea-Fortified Cupcakes upon Air Frying and Oven Baking

Beneficial medicinal effects and material applications of rose

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