Tricyclic antidepressants for ADHD in children and adolescents

Otasowie, John; Ehimare, Umunoibalo; Chalhoub, Nevyne; Mayowe, Varaidzo

doi:10.1002/14651858.cd006997

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…One protocol (67) was excluded because it examined a different disorder, and two reviews (68;69) and five protocols (70)(71)(72)(73)(74) were excluded because they examined pharmacological treatments for ADHD. The last four protocols (75-78) examined non-pharmacological treatments for ADHD in children (acupuncture, parent training interventions, polyunsaturated fatty acids and social skills training), but were excluded because the protocols were not yet available in full review format.…”

Section: Results Of the Searchmentioning

confidence: 99%

The Cochrane Library and Non‐Pharmacological Treatments for Attention Deficit Hyperactivity Disorder in Children and Adolescents: An Overview of Reviews

Foisy

Williams

2011

Evid.‐Based Child Health

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Background: Attention deficit hyperactivity disorder (ADHD) is a chronic behavioural disorder that affects 5-8% of children. It is characterized by age-inappropriate levels of inattention, hyperactivity and impulsivity that cause functional impairment in multiple settings. The most common treatment of ADHD involves prescription of stimulant medications, which often cause undesirable side effects and pose unknown long-term health risks. Therefore, alternative treatment options for ADHD are becoming increasingly popular and need to be further investigated.Objectives: This overview of reviews aims to synthesize evidence from the Cochrane Database of Systematic Reviews (CDSR) on the efficacy and safety of non-pharmacologic treatments to improve symptoms of ADHD in children and adolescents. Methods:Issue 12, 2010 of the CDSR was searched using the terms "attention deficit hyperactivity disorder", "hyperkinetic disorder" and "ADHD" restricted to the title, abstract or keywords, and all systematic reviews examining non-pharmacologic treatments for ADHD in children and adolescents were identified. Data were extracted, complied into tables and synthesized using qualitative and quantitative methods.Main Results: Three systematic reviews (containing ten trials and 594 participants) were identified for inclusion in this overview. Children assigned to Hatha yoga versus a non-specific physical activity control condition showed significantly less symptoms of inattention when measured using both parent ratings (MD: −0.73; 95% CI: −1.25, −0.21) and child-completed tests (MD: −4.01; 95% CI: −6.23, −1.79). There was no significant benefit of homeopathy compared to homeopathy placebo in decreasing symptoms of ADHD. There was also no significant difference between family therapy and standard treatment for parent and teacher ratings of inattention and hyperactivity/impulsivity; however, when overall symptoms were judged by a blinded third party observer in the classroom setting, standard treatment was significantly more effective (MD: 0.11; 95% CI: 0.05, 0.17). There was no significant difference between meditation therapy compared to both drug therapy and standard treatment without drugs for decreasing symptoms of inattention, hyperactivity, impulsivity, distractibility or overall symptoms. Authors' Conclusions:The three Cochrane reviews suffered from a lack of high-quality, adequately powered randomized controlled trials using standardized tools to measure clinically important outcomes over adequate periods of time. Therefore, the trials included in this overview are not sufficient to provide evidence of no positive benefit of treatment, nor are they sufficient to recommend the use Hatha yoga, family therapy, meditation therapy or homeopathy for the treatment of ADHD in children and adolescents. Editors

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Section: Results Of the Searchmentioning

confidence: 99%

The Cochrane Library and Non‐Pharmacological Treatments for Attention Deficit Hyperactivity Disorder in Children and Adolescents: An Overview of Reviews

Foisy

Williams

2011

Evid.‐Based Child Health

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“…The critical discourse regarding how to use psychotropic medications in children with MHNDDs has been ongoing for several years ( 42 – 44 ). Trends to medicate children seem to be specific to North America.…”

Section: Discussionmentioning

confidence: 99%

Understanding patient characteristics and medication prescriptions in children with mental health and neurodevelopmental disorders referred to a sleep clinic—A quality improvement/quality assurance analysis

et al. 2022

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IntroductionMotivated by challenges faced in outpatient sleep services for mental health and neurodevelopmental disorders (MHNDD) during the COVID-19 clinical shutdown, a pan-Canadian/international working group of clinicians and social scientists developed a concept for capturing challenging sleep and wake behaviours already at the referral stage in the community setting.MethodsIn a quality improvement/quality assurance (QIQA) project, a visual logic model was the framework for identifying the multiple causes and possible interventions for sleep disturbances. Intake forms informed clinicians about situational experiences, goals/concerns, in addition to the questions from the Sleep Disturbances Scale for Children (SDSC), the ADHD Rating Scale-IV and medication history. Descriptive statistics were used to describe the sample.Results66% of the pilot study patients (n = 41) scored in the SDSC red domains (highest scoring) with highest sub-scores for insomnia (falling asleep 73%; staying asleep: 51%) and daytime somnolence (27%). A total of 90% of patients were taking at least one medication; 59% sleep initiation/sleep medications, 41% in combination with further non-stimulant medications, 9% with stimulants, 27% with antidepressants and 18% with antipsychotics. Polypharmacy was observed in 62% of all patients and in 73% of the ones medicated for sleep disturbances. Qualitative information supported individualisation of assessments.ConclusionOur intake process enabled a comprehensive understanding of patients’ sleep and wake profiles prior to assessment, at the referral stage. The high prevalence of insomnia in patients, combined with polypharmacy, requires special attention in the triaging process at the community level.

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Tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents

Otasowie

Castells

Ehimare

et al. 2014

Cochrane Database of Systematic Reviews

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Tricyclic antidepressants for ADHD in children and adolescents

Cited by 4 publications

References 27 publications

The Cochrane Library and Non‐Pharmacological Treatments for Attention Deficit Hyperactivity Disorder in Children and Adolescents: An Overview of Reviews

The Cochrane Library and Non‐Pharmacological Treatments for Attention Deficit Hyperactivity Disorder in Children and Adolescents: An Overview of Reviews

Understanding patient characteristics and medication prescriptions in children with mental health and neurodevelopmental disorders referred to a sleep clinic—A quality improvement/quality assurance analysis

Tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents

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