Tried and tested: the psychometric properties of the multiple sclerosis impact scale (MSIS-29) in a population-based study

Gray, OM; McDonnell, G V; Hawkins, S. A.

doi:10.1177/1352458508096872

Cited by 52 publications

(47 citation statements)

References 22 publications

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“…The relationship between the physical and psychological impacts of MS measured via the MSIS-29 has been documented [25], [30], [31] and we have confirmed this in our cohort [28]. However, the MSIS-29 is not designed to distinguish between anxiety and depression and these conditions require specific courses of treatment and care.…”

Section: Introductionsupporting

confidence: 77%

Physical Disability, Anxiety and Depression in People with MS: An Internet-Based Survey via the UK MS Register

Jones

Middleton

et al. 2014

PLoS ONE

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IntroductionPeople with Multiple Sclerosis are known to have a relatively high prevalence of both anxiety and depression. Studies of the relationship between physical disability and mental health in people with MS have reported mixed results, showing the need for further work.MethodsBetween May 2011 and April 2012, 4516 people completed the MSIS-29 (v.1) and HADS scales via the dedicated internet site of the UK MS Register within a 7 day time window. These responses were linked with basic demographic and descriptive data and analysed in SPSS (v.20).ResultsThe proportions of people experiencing anxiety or depression increased with physical disability such that 38.0% of respondents with low, and 66.7% with high disability reported at least mild anxiety, and 17.1% of people with low, and 71.7% with high disability experienced at least mild depression. The multiple regression model explained 18.4% of the variance in anxiety with MSIS-29-PHYS score being the strongest predictor of anxiety. The model for depression explained 37.8% of the variance with MSIS-29-PHYS score being the strongest predictor. Some of the other variables included showed negative associations with anxiety and depression, indicating that the influence of physical disability on mental wellbeing could be underestimated.ConclusionsThis study indicates that there is a positive relationship between physical disability and anxiety and depression, that physical disability impacts on anxiety and depression to differing extents, and that the effects vary with gender, age, disease course and disease duration. We have shown that physical disability is a predictor of anxiety and depression, and that other factors may mask the extent of this effect. Whether the causes of anxiety and depression are reactive, organic or a combination, it is essential that mental wellbeing is given due attention in caring for people with MS so that all their health needs can be met.

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Section: Introductionsupporting

confidence: 77%

Physical Disability, Anxiety and Depression in People with MS: An Internet-Based Survey via the UK MS Register

Jones

Middleton

et al. 2014

PLoS ONE

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“…Much like multiple previous studies using classical test theory methods in community-based populations, 11–20 the current study using the SELECT clinical trial population found support for the internal consistency and test-retest reliability, construct validity, and responsiveness of the MSIS-29v1 longitudinally over 52 weeks in patients with RRMS.…”

Section: Discussionsupporting

confidence: 76%

“…Multiple investigations using traditional psychometric analyses based on classical test theory have been conducted to assess the psychometric properties of the instrument, providing evidence of the instrument’s reliability, validity, and responsiveness. 11–20 …”

Section: Introductionmentioning

confidence: 99%

Analysis of the psychometric properties of the Multiple Sclerosis Impact Scale-29 (MSIS-29) in relapsing–remitting multiple sclerosis using classical and modern test theory

Bacci¹,

Wyrwich²,

Phillips

et al. 2016

Multiple Sclerosis Journal - Experimental, Translational and Cl

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BackgroundInvestigations using classical test theory support the psychometric properties of the original version of the Multiple Sclerosis Impact Scale (MSIS-29v1), a disease-specific measure of multiple sclerosis (MS) impact (physical and psychological subscales). Later, assessments of the MSIS-29v1 in an MS community-based sample using Rasch analysis led to revisions of the instrument’s response options (MSIS-29v2).ObjectiveThe objective of this paper is to evaluate the psychometric properties of the MSIS-29v1 in a clinical trial cohort of relapsing–remitting MS patients (RRMS).MethodsData from 600 patients with RRMS enrolled in the SELECT clinical trial were used. Assessments were performed at baseline and at Weeks 12, 24, and 52. In addition to traditional psychometric analyses, Item Response Theory (IRT) and Rasch analysis were used to evaluate the measurement properties of the MSIS-29v1.ResultsBoth MSIS-29v1 subscales demonstrated strong reliability, construct validity, and responsiveness. The IRT and Rasch analysis showed overall support for response category threshold ordering, person-item fit, and item fit for both subscales.ConclusionsBoth MSIS-29v1 subscales demonstrated robust measurement properties using classical, IRT, and Rasch techniques. Unlike previous research using a community-based sample, the MSIS-29v1 was found to be psychometrically sound to assess physical and psychological impairments in a clinical trial sample of patients with RRMS.

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“…It has a physical and a psychological component and is transposed to a score out of 100, and higher scores reflect higher impact of MS. The scale has previously been found to be valid and reliable for use in PwMS, including in those with severe disabilities (Riazi et al, 2002, Riazi et al, 2003, McGuigan and Hutchinson, 2004, Gray et al, 2009). The Guy's Neurological Disability Rating Scale (GNDS) measures levels of disability across 12 categories including cognition, mood, speech, upper and lower limb function, and fatigue (Sharrack and Hughes, 1999).…”

Section: Outcome Assessmentmentioning

confidence: 99%

Augmenting home exercise programmes in multiple sclerosis with ‘exercise buddies’: A pilot study

Toomey

Coote

2017

International Journal of Therapy and Rehabilitation

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Tried and tested: the psychometric properties of the multiple sclerosis impact scale (MSIS-29) in a population-based study

Abstract: The MSIS-29 is an acceptable, reliable, and valid method of recording quality of life. A significant relationship between higher physical impact scores of the MSIS-29 and higher Kurtzke EDSS values suggests that is may be of use in clinical trials to monitor progression.

Cited by 52 publications

References 22 publications

Physical Disability, Anxiety and Depression in People with MS: An Internet-Based Survey via the UK MS Register

Physical Disability, Anxiety and Depression in People with MS: An Internet-Based Survey via the UK MS Register

Analysis of the psychometric properties of the Multiple Sclerosis Impact Scale-29 (MSIS-29) in relapsing–remitting multiple sclerosis using classical and modern test theory

Augmenting home exercise programmes in multiple sclerosis with ‘exercise buddies’: A pilot study

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