Triethylamine‐Catalyzed Synthesis of Oxazepine from Maleamic Acids

Abstract

in Wiley Online Library (wileyonlinelibrary.com).2-Thioxo-1,3-oxazepine-4,7-dione compounds were obtained via triethylamine-catalyzed condensation of maleamic acids with thiophosgene under anhydrous conditions. This method features relatively a simple methodology, use of inexpensive reagents, convenient operating conditions and high yields.

Green Synthesis of Symmetric Dimaleamic Acids from Dianilines and Maleic Anhydride: Behind New Bidentate Ligands for MOFs

“…The N-substituted maleamic acids are highly conjugated, and their use as polydentate ligands has been well documented with lanthanide ions such as La 3+ [11], Eu 3+ , Tb 3+ and Yb 3+ [12], and transition metals such as Cu 2+ [13,14]. The most common method for the maleamic acid synthesis involves the reaction between a primary amine and maleic anhydride under mild reaction conditions (Scheme 1), in a wide variety of solvents, for instance, dichloromethane [15], diethyl ether [16], toluene [17], tetrahydrofuran [18] or xylene [19], which may pose health and environmental hazards. Scheme 1.…”