Triflic Acid Catalyzed Intermolecular α-Amination of Pterolactams To Give 5-Arylaminopyrrolidinones via N-Acyliminium Species

Abstract

Starting materials are commercially available. Melting points were measured on an MPA 100 OptiMelt® apparatus and are uncorrected. NMR spectra were acquired at 200 MHz for 1 H NMR on a Varian Gemini 2000® spectrometer, or at 400 MHz for 1 H NMR and 100 MHz for 13 C NMR on a Varian 400 MHz Premium Shielded® spectrometer. Chemical shifts (δ) are expressed in parts per million relative to TMS as internal standard. Thin layer chromatography (TLC) was realized on Macherey Nagel silica gel plates with fluorescent indicator and was visualized under a UV-lamp at 254 nm and 366 nm. Column chromatography was performed on silica gel (40-60 µm; Macherey Nagel). IR spectra were recorded on a Varian 640-IR FT-IR Spectrometer. Elemental analysis (C, H, N, S) of new compounds was determined