Triflic acid-promoted post-Ugi condensation for the assembly of 2,6-diarylmorpholin-3-ones

Abstract

We report a two-step one-pot synthesis of 2,6-diarylmorpholin-3-one core based on Ugi reaction of 2-oxoaldehyde with 2-hydroxycarboxylic acid, primary amine and tert-butyl isocyanide followed by a triflic-acid promoted intramolecular condensation...