Trifluoroacetic Anhydride

Trifluoroacetic Anhydride Mediated One-Pot Synthesis of 1-Aryl Isochroman-3-ones via the Carboxy-Pictet–Spengler Reaction

“…In eq 2 (Scheme ), only 2 equiv of trifluoroacetic acid (TFA, a byproduct) is generated from the hydrolysis of TFAA with the in situ formed H 2 O. This is important from a facile-operational point of view because a TFAA-mediated reaction possesses excellent selectivity and activity, and it produces high-yield products. , …”

Selective Functionalization of Tetrathiafulvalene Using Mg- and Zn-TMP-Bases: Preparation of Mono-, Di-, Tri-, and Tetrasubstituted Derivatives

“…Methylthiolation of 5 is performed using MeSO 2 SMe affording the thioether ( 6d ) in 89% yield (entry 4). An aminomethylation of 5 using the iminium salt Me 2 NCH 2 OCOCF 3 12 provides the amine 6e in 55% yield (entry 5). The acylation of 5 can be directly achieved by the addition of DMF or ethyl cyanoformate leading to the aldehyde 6f and the ester 6g in 60–72% yield (entries 6–7; for single-crystal X-ray structure analysis of 6g , see the Supporting Information , Figure S3).…”