Trifluoroiodomethane

Recyclable Trifluoromethylation Reagents from Fluoroform

“…The high cost of trifluoromethylation reagents stems largely from their multistep syntheses from CF 3 Br or CF 3 I. , The regeneration of the B 3 N 3 Me 6 LA in the reactions noted above suggested that these popular reagents could be prepared from HCF 3 using B 3 N 3 Me 6 as a recyclable component, thereby reducing the reaction inputs to base, HCF 3 , and the direct precursor (Figure ). Reagents used to install the CF 3 group can be divided between their use for CF 3 – , CF 3 ·, and CF 3 + transfer .…”