Trifluoromethyl-containing pyrazolinyl (p-tolyl) sulfones: The synthesis and structure of promising antimicrobial agents

Synthesis of new trihalomethylated and non-symmetrical substituted 2-(1H-pyrazolyl)-5-(1H-pyrazolylcarbonyl)pyridines

“…[28][29][30][31] Compounds 3a-i show 1 H NMR chemical shifts of the diastereotopic methylene protons characteristic of pyrazoline system and as doublets at 3.73 and 3.35 ppm, with a geminal coupling constant in the range of 2 J 18 Hz; compounds 4c-f present a pyrazoline system as a doublet at 4.07 and 3.77 ppm, with a coupling constant of 2 J 18 Hz. The trifluoromethylated heterocycles present the typical 13 …”

β-Alkoxyvinyl trifluoromethyl ketones as efficient precursors for the one-pot synthesis of bis-(4,5-dihydro-1H-pyrazol-1-yl)methanones and 1H-pyrazolyl-1-carbohydrazides

“…In particular, the synthetic potential of β-alkoxyvinyl trifluoromethyl ketones to obtain a series of novel trifluoromethylated pyrazoles has recently been explored and their biological evaluation reported by us. 10,13,[21][22][23] The reactions of 4-alkoxy-4-aryl(heteroaryl)-1,1,1-trifluoro-3-alken-2-ones (1b-e,1h-i) with carbohydrazide were carried out in 1:1 molar ratio in ethanol, and all reactions were monitored by TLC. The most satisfactory results were obtained when the reactions were performed under mild conditions.…”

4-[(1,3-Thiazol-2-yl)sulfamoyl]phenyl 2,2,2-trifluoroacetate

“…For the biological efficacy of F and CF 3 in medicinal chemistry, see: Fokin & Kolomiyets (1988); Bonacorso et al (2006). For background to the biological applications of sulfonamides, see: Croitoru et al (2004); Dogruer et al (2010).…”