Trigeminal Neuralgia Commonly Precedes the Diagnosis of Multiple Sclerosis

Fallata, Ahmad; Salter, Amber; Tyry, Tuula; Cutter, Gary; Marrie, Ruth Ann

doi:10.7224/1537-2073.2016-065

Cited by 40 publications

(36 citation statements)

References 25 publications

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“…22 The age of onset of TN symptoms, mean 46.6 years in our study, is comparable to the age of TN onset in other studies on MS patients. 12,17 Although our TN cohort is hospital-based, the symptoms of TN are often so severe that referral to a neurological outpatient clinic is likely, making the incidence estimation more reliable. The coverage of our referral-based TN population is strengthened also by the reimbursement policy for TN treatments in Finland, requiring a statement from a neurologist or neurosurgeon.…”

Section: Discussionmentioning

confidence: 99%

“…9,10 There is a clear association of TN with MS, as the prevalence of TN in MS patients has been reported to vary between 1.1% and 6.3%. [11][12][13][14][15][16] A survey-based study estimated the prevalence of TN in MS patients to be as high as 9.7%, 17 but there are limitations to the reliability of this study approach. An even larger variation is seen in the results of studies on the aetiology of TN in MS patients, reflecting their paucity and small size with fewer than ten patients, where an associated demyelinating lesion of the pons has been identified with a highly variable portion in 14%-100% of patients.…”

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confidence: 99%

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Trigeminal neuralgia in multiple sclerosis: Prevalence and association with demyelination

et al. 2020

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Multiple sclerosis (MS) is the most common chronic autoimmune disease attacking the brain and spinal cord. The prevalence of MS in Finland is one of the highest in the world, with a crude estimate of 247/100 000. 1 Disease course is relapsing remitting (RRMS) in approximately 85% of patients, where a new demyelinating lesion or lesions may cause a new symptomatic period. Demyelinating lesions of the brain stem can present with symptoms of the cranial nerves, such as sudden sensorineural hearing loss, 2 abnormal eye movements 3 or facial motor paresis, 4 in addition to painful trigeminal neuralgia (TN).

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Trigeminal neuralgia in multiple sclerosis: Prevalence and association with demyelination

et al. 2020

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“…Indeed, it has been suggested that proprioceptive alterations and cerebellar ataxia (deficits in the voluntary coordination of muscle movements), 23 25,26,41,42 . Although in some studies these manifestations have been shown to precede multiple sclerosis diagnosis 41,42,48 (and therefore potentially contributing to differential diagnosis), a longer duration of illness has also been linked to an increased likelihood of developing these oro-facial manifestations, 26 indicating that from a clinical perspective it becomes increasingly important to look for signs of these manifestations in later stages of the disorder.…”

Section: Discussionmentioning

confidence: 99%

A systematic review of oral health in people with multiple sclerosis

Manchery

Nangle

2019

Comm Dent Oral Epid

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Objectives Despite more than 25 years of research focused on this topic, it remains unclear whether people with multiple sclerosis are more likely to present with oral health problems. The aim of this study was to provide the first systematic review of this literature. Methods A literature search for studies focused on oral health and multiple sclerosis was conducted using PRISMA guidelines. Electronic databases (PubMed, Scopus, Web of Science, MEDLINE and CINAHL) were searched up until February 2019. Two independent coders extracted data, and study quality graded using the Newcastle‐Ottawa Scale (NOS). Results From 1281 articles identified, 17 met all the eligibility criteria. Of the seventeen studies, more than half included a nonclinical control group, and the majority were observational studies. The included studies were of poor to moderate quality. Taken together, the results provided only very limited evidence that people with multiple sclerosis are more likely to present with dental caries and gingival disease. There was suggestive evidence that people with multiple sclerosis may be at higher risk of periodontal disease and present with poorer oral hygiene, and moderate evidence for an association between multiple sclerosis and temporomandibular disorders. Conclusions This systematic review provides evidence of an association between multiple sclerosis and at least some oral health problems. When temporomandibular disorders and periodontal status specifically have been assessed, most studies provide evidence of an association with multiple sclerosis. However, this review also clearly highlights the need for further, high‐quality studies in this area.

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“…Trigeminal neuralgia (TN) is characterized by a brief electric shock like pain in one or more divisions of the trigeminal nerve territories. TN is not uncommon in MS with an estimated prevalence of 1.9% to 4.9% [ 66 ], with 10–14% being the first manifestation of the disease [ 67 ]. Compared to patients with primary TN, TN secondary to MS occurs at a younger age, has a lower frequency of ophthalmic division involvement, higher frequency of bilateral trigeminal nerve involvement [ 66 ], and higher incidence of sensory deficit [ 68 ].…”

Section: Paroxysmal Symptoms Categoriesmentioning

confidence: 99%

Paroxysmal Symptoms in Multiple Sclerosis—A Review of the Literature

Freiha

Riachi

Chalah

et al. 2020

JCM

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Paroxysmal symptoms are well-recognized manifestations of multiple sclerosis (MS). These are characterized by multiple, brief, sudden onset, and stereotyped episodes. They manifest as motor, sensory, visual, brainstem, and autonomic symptoms. When occurring in the setting of an established MS, the diagnosis is relatively straightforward. Conversely, the diagnosis is significantly more challenging when they occur as the initial manifestation of MS. The aim of this review is to summarize the various forms of paroxysmal symptoms reported in MS, with emphasis on the clinical features, radiological findings and treatment options.

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Trigeminal Neuralgia Commonly Precedes the Diagnosis of Multiple Sclerosis

Cited by 40 publications

References 25 publications

Trigeminal neuralgia in multiple sclerosis: Prevalence and association with demyelination

Trigeminal neuralgia in multiple sclerosis: Prevalence and association with demyelination

A systematic review of oral health in people with multiple sclerosis

Paroxysmal Symptoms in Multiple Sclerosis—A Review of the Literature

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