Trigeminal schwannoma

Agrawal, Ajai; Singh, Virendra; Rohilla, Seema; Sharma, Bhisham

doi:10.4103/njms.njms_82_14

Cited by 14 publications

(12 citation statements)

References 9 publications

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“…These lesions are isointense to slightly hyperintense on T1-weighted images and isointense to hypointense on T2-weighted images. 15 A recently reported study revealed that due to the presence of melanin granules, MS and metastatic schwannomas have a similar appearance on MRI. A dumbbell-shaped growth and cystic structure are the indirect signs that favor MS over metastatic schwannomas.…”

Section: Discussionmentioning

confidence: 97%

A Case of Malignant Melanotic Schwannoma of the Trigeminal Nerve: A Case Report and Review of Literature

Dandekar

Mehta

2023

Asian J Neurosurg

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Intracranial melanotic schwannoma is quite rare, and involvement of the trigeminal nerve is even rarer. Early diagnosis and surgical excision are the mainstays of management. These tumors have a high tendency to recur and there is high possibility of metastasis. Adjuvant radiotherapy should be considered since the prognosis is uncertain. A 23-year-old man started developing numbness over the left side of the forehead 9 months ago that progressed to involve the ipsilateral cheek. The patient started having diplopia on looking to the left side 8 months ago. His relatives noticed a change in his voice 1 month ago and he developed weakness in the right upper and lower limbs, which was gradually progressive. The patient had slight difficulty swallowing. After examination, we found involvement of multiple cranial nerves with pyramidal signs. Magnetic resonance imaging (MRI) was suggestive of an extra-axial lesion in the left cerebellopontine angle extending into the middle cranial fossa, which was having high T1 and T2 signal loss with contrast enhancement. We achieved near-total excision of the tumor via a subtemporal extradural approach. Trigeminal melanotic schwannoma is a rare occurrence constituting melanin-producing cells and Schwann cells. Rapid progression of symptoms and signs should prompt the suspicion of the possible malignant nature of the pathology. Extradural skull base approaches reduce the risk of postoperative deficits. Differentiating melanotic schwannoma from malignant melanoma is of utmost importance in planning of management.

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Section: Discussionmentioning

confidence: 97%

A Case of Malignant Melanotic Schwannoma of the Trigeminal Nerve: A Case Report and Review of Literature

Dandekar

Mehta

2023

Asian J Neurosurg

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“…TSs are benign tumors with slow growth that can develop anywhere in the intracranial and extracranial regions due to the course of the trigeminal nerve [19] . The course of the trigeminal nerve mainly involves 4 anatomical regions, including the trigeminal root in the PCF (subdural space), the trigeminal root or gasserian ganglion (GG) in the area of Meckel's capsule (interdural space), the trigeminal branches of the interdural structures, and the extracranial peripheral branches of the trigeminal nerve (epidural space) [20] .…”

Section: Discussionmentioning

confidence: 99%

Can Trigeminal Schwannomas in Middle Cranial Fossa Invade Cavernous Sinus

Yin,

Yang,

Zhang

et al. 2024

Preprint

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This study reports trigeminal schwannomas (TSs) in 13 cases whose cancer invaded the cavernous sinus (CS) in the middle cranial fossa (MCF). Seventy-eight patients who underwent surgical treatment in Beijing Tiantan Hospital in the last 6 years were retrospectively analyzed and a literature review was conducted. The patients were divided into 2 groups by definitive evidence of CS invasion during surgery. Group A included 65 cases. Six patients suffered from diplopia. Tumor size in their MCF ranged from 7 mm to 48 mm (mean: 23.5 ± 8.0 mm), and the gross total resection(GTR) was 93.8%. Group B included 13 cases, among whom 5 developed diplopia (p < 0.05). Tumor size in their MCF ranged from 17 mm to 44 mm (mean: 30.0 ± 7.7 mm) (p < 0.05), and the GTR was 69.2% (p < 0.05). In patients with CS invasion, there was a higher incidence of diplopia and larger tumor diameter. Gender, age, classification, nature, width of channel, and other clinical symptoms did not show statistical significance. So the TSs can invade CS, which can lower GTR. Some features may help predict the invasion, and a thorough preoperative assessment is helpful.

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“…Trigeminal schwannomas are rare tumors, accounting for 1-2% of all intracranial schwannomas and tend to occur predominantly in the 4th-6th decades [1]. The lesions are solitary, slow growing, and generally not associated with neurologic symptoms [2]. The standard treatment is surgery, and these tumors were said to be radioresistant [2,3].…”

Section: Discussionmentioning

confidence: 99%

“…The lesions are solitary, slow growing, and generally not associated with neurologic symptoms [2]. The standard treatment is surgery, and these tumors were said to be radioresistant [2,3]. However, Kharod et al reported recently that fractionated radiation therapy for benign nonacoustic schwannoma to a total dose of 50 Gy provided excellent local control and minimal morbidity [4].…”

Section: Discussionmentioning

confidence: 99%

Multisession CyberKnife Radiosurgery for Symptomatic Abducens Nerve Palsy

Harada

2019

BJSTR

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Abducens nerve palsy causes diplopia which lowers patients' quality of life. Nerve palsy due to tumor compression is treated by surgery, but Abducens nerve is difficult to access. Ten patients with benign and malignant tumors in cavernous sinus and cliva were involved in this study: trigeminal schwannoma, meningioma, cavernous hemangioma, metastatic tumors from prostate, breast, and uterus cancer. They were treated with multisession CyberKnife radiosurgery on outpatient bases. Diplopia was treated in all the patients, without any significant adverse effects. The longest follow-up was over 10 years, with all patients leading normal lives. This is the first study to evaluate the use of CyberKnife radiosurgery for the treatment of diplopia.

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Trigeminal schwannoma

Cited by 14 publications

References 9 publications

A Case of Malignant Melanotic Schwannoma of the Trigeminal Nerve: A Case Report and Review of Literature

A Case of Malignant Melanotic Schwannoma of the Trigeminal Nerve: A Case Report and Review of Literature

Can Trigeminal Schwannomas in Middle Cranial Fossa Invade Cavernous Sinus

Multisession CyberKnife Radiosurgery for Symptomatic Abducens Nerve Palsy

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