Triggered-release drug delivery nanosystems for cancer therapy by intravenous injection: where are we now?

Huo, Minfeng; Chen, Yu; Shi, Jianlin

doi:10.1080/17425247.2016.1213241

Cited by 22 publications

(10 citation statements)

References 17 publications

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“…It was deduced that the cavitation effect of US changed the interior volume and flexibility of surface PDMS, opened the nanovalves and triggered the drug releasing subsequently. However, the traditional sealing of drug molecules within the mesopores by designing various caps on the mesopore surface is relatively not practical for clinical translation because the capping process was a bit complicated and might cause the potential toxicity . We recently incorporated organic groups (e.g., R = phenylene or thioether) within the framework of mesoporous silica to fabricate molecularly organic/inorganic‐hybrid mesoporous organosilica NPs (MONs, Figure d and e) .…”

Section: Us‐triggered Responsive Drug Releasing and Gene Transfectionmentioning

confidence: 99%

Materials Chemistry of Nanoultrasonic Biomedicine

2016

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As a special cross-disciplinary research frontier, nanoultrasonic biomedicine refers to the design and synthesis of nanomaterials to solve some critical issues of ultrasound (US)-based biomedicine. The concept of nanoultrasonic biomedicine can also overcome the drawbacks of traditional microbubbles and promote the generation of novel US-based contrast agents or synergistic agents for US theranostics. Here, we discuss the recent developments of material chemistry in advancing the nanoultrasonic biomedicine for diverse US-based bio-applications. We initially introduce the design principles of novel nanoplatforms for serving the nanoultrasonic biomedicine, from the viewpoint of synthetic material chemistry. Based on these principles and diverse US-based bio-application backgrounds, the representative proof-of-concept paradigms on this topic are clarified in detail, including nanodroplet vaporization for intelligent/responsive US imaging, multifunctional nano-contrast agents for US-based multi-modality imaging, activatable synergistic agents for US-based therapy, US-triggered on-demand drug releasing, US-enhanced gene transfection, US-based synergistic therapy on combating the cancer and potential toxicity issue of screening various nanosystems suitable for nanoultrasonic biomedicine. It is highly expected that this novel nanoultrasonic biomedicine and corresponding high performance in US imaging and therapy can significantly promote the generation of new sub-discipline of US-based biomedicine by rationally integrating material chemistry and theranostic nanomedicine with clinical US-based biomedicine.

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Section: Us‐triggered Responsive Drug Releasing and Gene Transfectionmentioning

confidence: 99%

Materials Chemistry of Nanoultrasonic Biomedicine

2016

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“…From this section, we explain both concepts into the boundary of “active delivery,” as the technique selectively marks the target tumor cells depending on nanoparticle-cell interaction under specific target cell conditions. 105 The representative publications for absorption spectrum shift are summarized in Table V .…”

Section: Functionalizing P Cs and N Cs As A Photoacoustic Contrast Agentmentioning

confidence: 99%

New contrast agents for photoacoustic imaging and theranostics: Recent 5-year overview on phthalocyanine/naphthalocyanine-based nanoparticles

Park

et al. 2021

APL Bioengineering

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The phthalocyanine (Pc) and naphthalocyanine (Nc) nanoagents have drawn much attention as contrast agents for photoacoustic (PA) imaging due to their large extinction coefficients and long absorption wavelengths in the near-infrared region. Many investigations have been conducted to enhance Pc/Ncs' photophysical properties and address their poor solubility in an aqueous solution. Many diverse strategies have been adopted, including centric metal chelation, structure modification, and peripheral substitution. This review highlights recent advances on Pc/Nc-based PA agents and their extended use for multiplexed biomedical imaging, multimodal diagnostic imaging, and image-guided phototherapy.

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“…The drug delivery and therapeutic potential of AuNPs can be greatly enhanced by joining to these platforms another excellent drug delivery vehicle, liposomes (Lips) [ 134 , 135 , 136 ], which can be triggered by various chemical/physical stimuli [ 137 , 138 ]. The resulting hybrid systems are multifunctional, as both AuNPs and Lips can be widely decorated on their surface to achieve active/passive targeting delivery systems and/or stimuli-responsive systems.…”

Section: Gold-based Hybrid Nanosystemsmentioning

confidence: 99%

Natural Product-Based Hybrids as Potential Candidates for the Treatment of Cancer: Focus on Curcumin and Resveratrol

et al. 2021

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One of the main current strategies for cancer treatment is represented by combination chemotherapy. More recently, this strategy shifted to the “hybrid strategy”, namely the designing of a new molecular entity containing two or more biologically active molecules and having superior features compared with the individual components. Moreover, the term “hybrid” has further extended to innovative drug delivery systems based on biocompatible nanomaterials and able to deliver one or more drugs to specific tissues or cells. At the same time, there is an increased interest in plant-derived polyphenols used as antitumoral drugs. The present review reports the most recent and intriguing research advances in the development of hybrids based on the polyphenols curcumin and resveratrol, which are known to act as multifunctional agents. We focused on two issues that are particularly interesting for the innovative chemical strategy involved in their development. On one hand, the pharmacophoric groups of these compounds have been used for the synthesis of new hybrid molecules. On the other hand, these polyphenols have been introduced into hybrid nanomaterials based on gold nanoparticles, which have many potential applications for both drug delivery and theranostics in chemotherapy.

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Triggered-release drug delivery nanosystems for cancer therapy by intravenous injection: where are we now?

Cited by 22 publications

References 17 publications

Materials Chemistry of Nanoultrasonic Biomedicine

Materials Chemistry of Nanoultrasonic Biomedicine

New contrast agents for photoacoustic imaging and theranostics: Recent 5-year overview on phthalocyanine/naphthalocyanine-based nanoparticles

Natural Product-Based Hybrids as Potential Candidates for the Treatment of Cancer: Focus on Curcumin and Resveratrol

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