Triggering Mechanisms of Thermosensitive Nanoparticles Under Hyperthermia Condition

Dabbagh, Ali; Abdullah, Basri Johan Jeet; Abdullah, Hadijah; Hamdi, M.; Kasim, Noor Hayaty Abu

doi:10.1002/jps.24536

Cited by 21 publications

(13 citation statements)

References 192 publications

(210 reference statements)

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“…These nanoparticles could also provide a synergistic effect of chemotherapy and hyperthermia when sufficient dosages of chemotherapeutics are conjugated on their surfaces. The drug-loaded MNPs could further be navigated through the body via external magnetic fields with appropriate driving forces to actively target the tumor site and release their cargo, while simultaneously produce a significant amount of thermal energy by different mechanisms such as hysteresis loss, Neel relaxation, Brown relaxation, and frictional losses [2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…Hence, synthesis of MNPs with porous structure is a particular solution to achieve higher drug loading capacities [11][12][13]. Moreover, MNPs could be coated by different thermosensitive agents to protect the encapsulated compounds from uncontrolled leakage [7,8,[14][15][16]. When the particles reach the target tumor, the produced thermal energy dissociates the protective shell and facilitates release of the therapeutic load [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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Polyethylene glycol-coated porous magnetic nanoparticles for targeted delivery of chemotherapeutics under magnetic hyperthermia condition

Dabbagh

Hedayatnasab

Karimian

et al. 2018

International Journal of Hyperthermia

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polyethylene glycol-coated porous magnetic nanoparticles for targeted delivery of chemotherapeutics under magnetic hyperthermia condition

Dabbagh

Hedayatnasab

Karimian

et al. 2018

International Journal of Hyperthermia

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“…In addition to a number of general parameters such as biocompatibility and biodegradability, the clinical efficacy of these thermosensitive nanocarriers in hyperthermia application mainly relies on the temperature range and discontinuity of their physical phase transition mechanisms [12].…”

Section: Introductionmentioning

confidence: 99%

Low-melting-point polymeric nanoshells for thermal-triggered drug release under hyperthermia condition

Dabbagh

Mahmoodian

Abdullah

et al. 2015

International Journal of Hyperthermia

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Purpose: The aim of this paper was to synthesise core-shell nanostructures comprised of mesoporous silica core and a low melting-point polyethylene glycol (PEG) nanoshell with a sharp gel-liquid phase transition for rapid drug release at hyperthermia temperature range. Materials and methods:The phase transition behaviours of PEGs with molecular weights of 1000, 1500, and 2000 Da were analysed using differential scanning calorimetry (DSC) to determine the optimal formulation with phase transition in the hyperthermia range. The 'graftto' method was employed to synthesise core-shell nanostructures using the selected PEG formulation. The drug loading and release behaviours of these nanocarriers were examined by ultra-violet visible spectroscopy (UV-Vis) using doxorubicin as a model drug. Magnetic resonance-guided focused ultrasound (MRgFUS) was also applied as a typical thermal modality to evaluate the rate of drug release from the core-shell nanostructures. Results: The PEG molecular weight of 1500 Da presented the optimal phase transition temperature for thermaltriggered release under hyperthermia conditions. Drug release measurements at different temperatures using UV-Vis methods showed a 20.2 ± 4.3% leakage in aqueous solution at 37 C after 30 min, while this value was significantly increased to 68.2 ± 3.7% at 50 C. A 45.5 ± 3.1% drug release was also obtained after sonication of the drug-loaded nanoparticles for 5 Â 20 s using MRgFUS. Conclusion: Although the ratio of drug leakage at physiological temperatures was relatively high, the sharp transition temperature, high loading efficiency, and fast drug release at hyperthermia temperature range could make these core-shell nanoparticles prominent for enhancing the efficacy of various hyperthermia modalities in the treatment of cancer tumours.

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“…Illustration of the volume phase transition obtained with LCST polymers leading to a coil-to-globule conformation change. Above LCST, the aqueous content (drug) is released through polymer chain collapse [81]. …”

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confidence: 99%

Drug releasing nanoplatforms activated by alternating magnetic fields

Mertz

Sandre

Bégin‐Colin

2017

Biochimica et Biophysica Acta (BBA) - General Subjects

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The use of an alternating magnetic field (AMF) to generate non-invasively and spatially a localized heating from a magnetic nano-mediator has become very popular these last years to develop magnetic hyperthermia (MH) as a promising therapeutic modality already used in the clinics. AMF has become highly attractive this last decade over others radiations, as AMF allows a deeper penetration in the body and a less harmful ionizing effect. In addition to pure MH which induces tumor cell death through local T elevation, this AMF-generated magneto-thermal effect can also be exploited as a relevant external stimulus to trigger a drug release from drug-loaded magnetic nanocarriers, temporally and spatially. This review article is focused especially on this concept of AMF induced drug release, possibly combined with MH. The design of such magnetically responsive drug delivery nanoplatforms requires two key and complementary components: a magnetic mediator which collects and turns the magnetic energy into local heat, and a thermoresponsive carrier ensuring thermo-induced drug release, as a consequence of magnetic stimulus. A wide panel of magnetic nanomaterials/chemistries and processes are currently developed to achieve such nanoplatforms. This review article presents a broad overview about the fundamental concepts of drug releasing nanoplatforms activated by AMF, their formulations, and their efficiency in vitro and in vivo. This article is part of a Special Issue entitled "Recent Advances in Bionanomaterials" Guest Editors: Dr. Marie-Louise Saboungi and Dr. Samuel D. Bader.

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Triggering Mechanisms of Thermosensitive Nanoparticles Under Hyperthermia Condition

Cited by 21 publications

References 192 publications

Polyethylene glycol-coated porous magnetic nanoparticles for targeted delivery of chemotherapeutics under magnetic hyperthermia condition

Polyethylene glycol-coated porous magnetic nanoparticles for targeted delivery of chemotherapeutics under magnetic hyperthermia condition

Low-melting-point polymeric nanoshells for thermal-triggered drug release under hyperthermia condition

Drug releasing nanoplatforms activated by alternating magnetic fields

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