2014
DOI: 10.1007/s10295-013-1309-z
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Triggers and cues that activate antibiotic production by actinomycetes

Abstract: Actinomycetes are a rich source of natural products, and these mycelial bacteria produce the majority of the known antibiotics. The increasing difficulty to find new drugs via high-throughput screening has led to a decline in antibiotic research, while infectious diseases associated with multidrug resistance are spreading rapidly. Here we review new approaches and ideas that are currently being developed to increase our chances of finding novel antimicrobials, with focus on genetic, chemical, and ecological me… Show more

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Cited by 165 publications
(150 citation statements)
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References 166 publications
(149 reference statements)
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“…Colonies in coculture were spaced at 1-cm distances, thus permitting identification of strain-specific responses to social growth. Inhibition was measured in media with high (GA) and low (soil) resource levels that modify the level of resource competition cells experienced (7), which in turn may influence the cellular transition between growth and antibiotic production (21) and the types of antibiotics produced (1,22). The aim of these contrasting environments is to represent extremes in resource availability in soil microbial communities, because both possibilities are likely to be experienced by bacteria across time and space (23).…”
Section: Significancementioning
confidence: 99%
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“…Colonies in coculture were spaced at 1-cm distances, thus permitting identification of strain-specific responses to social growth. Inhibition was measured in media with high (GA) and low (soil) resource levels that modify the level of resource competition cells experienced (7), which in turn may influence the cellular transition between growth and antibiotic production (21) and the types of antibiotics produced (1,22). The aim of these contrasting environments is to represent extremes in resource availability in soil microbial communities, because both possibilities are likely to be experienced by bacteria across time and space (23).…”
Section: Significancementioning
confidence: 99%
“…Our results reveal that social interactions are crucial for understanding antibiosis and bacterial community dynamics, and highlight the potential of interbacterial interactions for novel drug discovery by eliciting pathways that mediate interference competition. T he discovery and development of antibiotics to fight bacterial diseases is one of the great triumphs in modern medicine (1). However, increasing rates of antimicrobial resistance require innovative strategies to replenish antimicrobial drug pipelines (2,3).…”
mentioning
confidence: 99%
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“…Of these 96, in total 89 strains were identified as Streptomyces (Zhu et al, 2014; Table S2, Fig. S2).…”
Section: Eliciting Antibiotics In Actinomycetesmentioning
confidence: 99%
“…Many approaches, including isolation of mutants altered in transcription or translation, genetic manipulation of positive and negative regulation, heterologous expression in specialized hosts and others, have been described. 8,[21][22][23][24][25][26][27][28][29][30] For microbial genome mining to become a robust methodology to drive the discovery of new and novel NPs for drug discovery, it is important to have a set of bioinformatics tools that can predict which microorganisms are the most 'gifted' for SM production. antiSMASH 3.0 31 is particularly useful to identify the numbers and types of SMs encoded by microbes, and has been used to survey a wide range of bacteria and archaea for those microorganisms most gifted for SM production.…”
Section: Introductionmentioning
confidence: 99%