Triglyceride and coronary heart disease mortality in a 24-year follow-up study in Xi'an, China

Elevated Triglyceride Level Is Independently Associated With Increased All-Cause Mortality in Patients With Established Coronary Heart Disease

“…21 Previous reports have shown an excessive risk for cardiovascular disease even among subjects with triglycerides levels within the so-called normal range. 9 Epidemiological data taken together raise the possibility that an optimal fasting triglyceride level might be <100 mg/dL. However, to the best of our knowledge, there were no published reports on the relationship between low-and highnormal levels of triglycerides and long-term mortality in populations with established CHD.…”

“…The inverse association between HDL-C and triglycerides complicates analysis designed to evaluate the independent contribution of elevated triglycerides levels to mortality. Although the majority of studies found a substantial direct association between triglycerides and adverse outcomes, [3][4][5][6][7][8][9][10][11]28,29 triglycerides have received less attention as a causal risk factor, as adjustment for HDL-C and other potential cofounders, tend to attenuate or nullify the association between triglycerides concentration and cardiovascular risk. [12][13][14][15]30,31 In a recent longitudinal observational study in out-patients with type 2 diabetes mellitus, mean triglycerides levels were significantly associated with all-cause mortality after adjustment for several confounding factors including mean values of HDL-C. 32 In our report, triglycerides levels are significantly associated with excessive risk for 22-year mortality, even after adjustment for HDL-C and for other potential confounders.…”

“…1,2 Although the majority of studies have shown a significant association between elevated triglycerides with adverse outcomes, [3][4][5][6][7][8][9][10][11] this association sometimes became nonsignificant after multivariate adjustment including other lipid levels and weight-related variables. [12][13][14][15] For example, in the largest meta-analysis to date, 12 triglycerides were shown to be independently associated with increased risk of coronary heart disease (CHD) after adjustment for age and sex, but this association became statistically nonsignificant after further adjustment for high-density lipoprotein (HDL)-cholesterol and non-HDL-C. As a result, the prognostic significance of hypertriglyceridemia and its role as a plausible therapeutic target is still a matter of active debates.…”

Triglycerides and Cardiovascular Disease

“…A low fasting triglyceride level (ie, Ͻ100 mg/dL) is commonly found in underdeveloped societies and countries at low CVD risk (eg, Africa, China, Greece, and Japan), [361][362][363][364][365][366][367][368][369][370][371][372][373] as contrasted with the United States, where mean levels are Ϸ15% to 30% higher. 6 Consistent with a reduced likelihood of abnormal metabolic parameters (eg, IR) are observational studies and clinical trials 3,232,367,374 -380 that have consistently demonstrated the lowest risk of incident and recurrent CVD in association with the lowest fasting triglyceride levels.…”

Effect of Caffeine on the Body Fat and Lipid Metabolism of Rats Fed on a High-Fat Diet

“…A risky relationship between serum lipids and cardiovascular disease has been reported, 18,19) so lowering the serum cholesterol and triglyceride levels is important for preventing high-mortality lifestyle-related cardiovascular diseases. CF can therefore be expected to help to prevent such diseases.…”