Triglyceride–glucose index, Alzheimer's disease plasma biomarkers, and dementia in older adults: The MIND‐China study

Abstract

Introduction Population‐based studies have rarely explored the associations of the triglyceride–glucose (TyG) index, a surrogate marker of insulin resistance, with dementia and plasma biomarkers for amyloid beta (Aβ) and neurodegeneration. Methods This population‐based study included 5199 participants (age ≥ 65 years); of these, plasma Aβ, total tau, and neurofilament light chain (NfL) were measured in 1287 persons. Dementia and subtypes were diagnosed following the international criteria. TyG index was calculated as ln(fasting triglyceride(mg/dL) × fasting glucose[mg/dL]/2). Data were analyzed using logistic and general linear regression models. Results Dementia, Alzheimer's disease (AD), and vascular dementia (VaD) were diagnosed in 301, 195, and 95 individuals, respectively. A high TyG index was significantly associated with increased likelihoods of dementia and AD; the significant association with dementia remained among participants without cardiovascular disease or diabetes. In the biomarker subsample, a high TyG index was correlated with elevated plasma Aβ, but not with total tau or NfL. Discussion High TyG index is associated with dementia, possibly via Aβ pathology.

Predicting the Rapid Progression of Mild Cognitive Impairment by Intestinal Flora and Blood Indicators through Machine Learning Method

“…Previous studies have found the correlation between triglyceride level and an increased risk of AD [17], in which high triglyceride level was significantly associated with an increased likelihood of dementia and AD. Among participants without cardiovascular disease or diabetes, the significant association with dementia remained and high triglyceride was associated with elevated plasma aβ [18]. Our study found that triglyceride was negatively correlated with Aβ1-40 and GFAP, which was consistent with previous research results to some extent.…”