Triglyceride-Glucose Index and Related Parameters Predicted Metabolic Syndrome in Nigerians

Raimi, Taiwo Hussean; Dele-Ojo, B F; Dada, Samuel Ayokunle; Fadare, Joseph; Ajayi, David Daisi; Ajayi, Ebenezer Adekunle; Ajayi, Oladimeji A

doi:10.1089/met.2020.0092

Cited by 91 publications

(97 citation statements)

References 26 publications

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“…The relationship between insulin resistance and the severity of coronary atherosclerosis in diabetic and nondiabetic patients have been shown in previous studies (24,25). TyG index is a marker associated with insulin resistance (26) and metabolic syndrome (27). The relationship between the TyG index and the presence and severity of CAD was supported by our study.…”

Section: Discussionsupporting

confidence: 89%

Koroner Arter Hastalığının Öngördürücüleri Olarak Trigliserid Glikoz İndeksi ve Trigliserid / HDL Oranı

Tolunay¹,

Fırtına²

2021

Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi

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Triglyceride to high density lipoprotein cholesterol (TG/HDL-C) ratio and triglyceride-glucose (TyG) index are simple, reliable screening methods. It has been shown that the TyG index predicts mortality in cardiovascular diseases, and the TG/HDL-C ratio predicts the severity of coronary artery disease (CAD). The aim of this study is to define the relationship between the SYNTAX score, which indicates the severity of CAD, and the TyG index and TG/HDL-C ratio. Material and Methods: A total of 408 patients who underwent coronary angiography were evaluated in this study. TyG index, TG/HDL-C ratio and SYNTAX scores were calculated. Patients were grouped according to their diagnosis and SYNTAX scores. Relationships between TyG index, TG/HDL-C ratio and SYNTAX score were examined. Results: There was a significant relationship between the TyG index and the presence of CAD (p<0.001). TyG index was significantly higher in patients with severe CAD than patients with mild CAD ((8.46±0.54) vs.(8.98±0.67), p=0.045). While there was a significant positive association between TG/HDL-C ratio and the presence of CAD (p<0.001), there was no significant relationship between severity of CAD (p=0.814). The TyG index values of those presenting with ST elevation myocardial infarction were higher than those presenting with stable angina pectoris (p=0.050). Conclusion:The TyG index and TG/HDL-C ratio were predictors of the presence of CAD and the TyG index also provides guidance on the severity of CAD. Standard use may be considered in addition to risk scoring in the diagnosis of CAD and planning coronary angiography.

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Section: Discussionsupporting

confidence: 89%

Koroner Arter Hastalığının Öngördürücüleri Olarak Trigliserid Glikoz İndeksi ve Trigliserid / HDL Oranı

Tolunay¹,

Fırtına²

2021

Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi

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“…The optimal thresholds for each index were selected, choosing the highest Youden's index value. First, a non-grouping analysis was performed, then curves were plotted, and calculations [12,13]. We estimated the ratio of negative to positive sample sizes as 0.6.…”

Section: Resultsmentioning

confidence: 99%

“…Insulin resistance indicators were calculated according to the following formulas: TyG = Ln [fasting TG (mg/dL) × FPG (mg/dL)/2], [14] TyG-BMI = TyG × BMI, [9] TyG-WC = TyG × WC, [9] TyG-WHtR = TyG × WHtR, [13] TyG-NC = TyG × NC, TyG-NHtR = TyG × NHtR, TG/HDLc = fasting TG (mg/dL)/fasting HDL cholesterol (mg/dL), [14] METS-IR = Ln [(2 × FPG (mg/dL) + fasting TG (mg/ dL)] × BMI (kg/m 2 ))/(Ln[HDLc (mg/dL]). [20]…”

Section: Insulin Resistance Indexesmentioning

confidence: 99%

“…In recent years, several indices calculated as products of TyG and anthropometric indices have been proposed, including TyG-waist circumference (TyG-WC), TyG-waist to height ratio (TyG-WHtR), and TyG-body mass index (TyG-BMI) [13]. The diagnostic accuracy of these indices in metabolic syndrome has been shown [13]. The relationship of insulin resistance indices with the metabolic syndrome components, especially hypertension and prehypertension state, was investigated [9,[14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Newly proposed insulin resistance indexes called TyG-NC and TyG-NHtR show efficacy in diagnosing the metabolic syndrome

Mirr

Skrypnik

Bogdański

et al. 2021

J Endocrinol Invest

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Purpose Obesity and insulin resistance are considered cardinal to the pathophysiology of metabolic syndrome. Several simple indexes of insulin resistance calculated from biochemical or anthropometric variables have been proposed. The study aimed to assess the diagnostic accuracy of indirect insulin resistance indicators in detecting metabolic syndrome in non-diabetic patients, including TG/HDLc, METS-IR, TyG, TyG-BMI, TyG-WC, TyG-WHtR, and new indicators TyG-NC (TyG-neck circumference) and TyG-NHtR (Tyg-neck circumference to height ratio). Methods The diagnostic accuracy of eight insulin resistance indexes was assessed using the receiver operating characteristic curves (ROC curves) in 665 adult non-diabetic patients. Then, the analysis was performed after the division into groups with proper body mass index, overweight and obese. Results All indexes achieved significant diagnostic accuracy, with the highest AUC (area under the curve) for TyG (0.888) and Tg/HDLc (0.874). The highest diagnostic performance in group with the proper body mass index was shown for TyG (0.909) and TyG-BMI (0.879). The highest accuracy in the group of overweight individuals was presented by TyG (0.884) and TG/HDLc (0.855). TG/HDLc and TyG showed the highest AUC (0.880 and 0.877, respectively) in the group with obesity. Both TyG-NC and TyG-NHtR reached significant areas under the curve, which makes them useful diagnostic tests in metabolic syndrome. Conclusions Indirect indices of insulin resistance, including proposed TyG-NC and TyG-NHtR, show an essential diagnostic value in diagnosing metabolic syndrome. TyG and TG/HDLc seem to be the most useful in the Caucasian population.

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“…Determination of IR with HOMA-IR involves an insulin assay that lacks standardization, and the use is limited by the instability and expense of insulin, especially in primary healthcare clinics. 10 , 11 Therefore, the triglyceride–glucose (TyG) index was proposed as a new, reliable marker of IR. The TyG index was calculated as the ln [fasting triglycerides (mg/dL) * fasting glucose (mg/dL)/2].…”

Section: Introductionmentioning

confidence: 99%

Association Between the Triglyceride–Glucose Index and Outcomes of Nonalcoholic Fatty Liver Disease: A Large-Scale Health Management Cohort Study

Liu¹,

Guan²,

Zhao³

et al. 2021

DMSO

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Background Nonalcoholic fatty liver disease (NAFLD) is increasingly becoming a major health burden. Due to the difficulty of liver biopsy, there is no reliable indicator to evaluate the outcomes of NAFLD. The triglyceride–glucose (TyG) index is a simple and convenient marker of insulin resistance for use in medical practice. Whether the TyG index is predictive of later risk of NAFLD remains unknown. Objective To evaluate the relationship between TyG index with NAFLD progression and improvement during a median follow-up period of 21 months. Material and Methods A total of 11,424 subjects (9327 men) diagnosed with NAFLD were included. The TyG index was calculated as follows: ln [fasting triglycerides (mg/dL) * fasting glucose (mg/dL)/2]. Multivariable Cox regression analysis was applied to analyze the data. Results In this study, the severity of NAFLD remained the same in 38.8% of subjects, worsened in 17.4% of subjects, and improved in 43.8% of subjects. Compared with the lowest quartile of the TyG index, the adjusted HR of NAFLD progression in the highest quartile (TyG≥9.34) was 1.448 (1.229 to 1.706), and the adjusted HR of NAFLD improvement was 0.817 (0.723 to 0.923). Subgroup analysis found that smoking increased the correlation between the TyG index and the risk of NAFLD progression, while female, vegan diet, and weight control enhanced the correlation between the TyG index and the risk of NAFLD improvement. Conclusion The TyG index may be a simple and helpful indicator for further risk appraisal of NAFLD in daily clinical practice.

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Triglyceride-Glucose Index and Related Parameters Predicted Metabolic Syndrome in Nigerians

Cited by 91 publications

References 26 publications

Koroner Arter Hastalığının Öngördürücüleri Olarak Trigliserid Glikoz İndeksi ve Trigliserid / HDL Oranı

Koroner Arter Hastalığının Öngördürücüleri Olarak Trigliserid Glikoz İndeksi ve Trigliserid / HDL Oranı

Newly proposed insulin resistance indexes called TyG-NC and TyG-NHtR show efficacy in diagnosing the metabolic syndrome

Association Between the Triglyceride–Glucose Index and Outcomes of Nonalcoholic Fatty Liver Disease: A Large-Scale Health Management Cohort Study

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