Triglyceride-Glucose Index and the Prognosis of Patients with Acute
                    Ischemic Stroke: A Meta-Analysis

Ma, Xueling; Han, Yuijia; Jiang, Lai; Li, Man

doi:10.1055/a-1853-9889

Cited by 8 publications

(3 citation statements)

References 42 publications

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“…Many previous studies have shown an association between a higher TyG index and an increased incidence of atherosclerosis, intima media thickness of common carotid artery, unstable carotid plaque, hypertension, arterial stiffness, and cardiovascular disease [10][11][12][13]. As expected, a plenty of evidences proved that TyG index was independently associated with the occurrence of stroke, and a higher TyG index was also a predictor of all-cause mortality and poor outcomes in patients with acute ischemic stroke [14][15][16][17].…”

Section: Introductionsupporting

confidence: 55%

Association of triglyceride-glucose index with ischemic stroke recurrence in nondiabetic patients with small vessel occlusion: a multicenter hospital-based prospective cohort study

Zhu

et al. 2022

Cardiovasc Diabetol

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Background Triglyceride-glucose (TyG) index is a simple and reliable surrogate marker of insulin resistance. Elevated TyG index was related to stroke recurrence. This study aimed to explore the associations between TyG index with ischemic stroke recurrence in nondiabetic patients with small vessel occlusion. Methods From November 1, 2016 to February 28, 2021, consecutive acute ischemic stroke patients admitted within 1 week after onset were screened. The stroke mechanism was determined based on medical history, laboratory examinations, cardiac examinations, vascular examinations and neuroimaging. Nondiabetic patients with small vessel occlusion were enrolled and followed up for 1 year. The primary outcome was ischemic stroke recurrence. Logistic regression and Kaplan–Meier survival curve were used to analyze the association of the TyG index and stroke recurrence. Results A total of 6100 acute ischemic stroke patients were screened, with 1970 nondiabetic patients with small vessel occlusion included and divided into 4 groups according to the TyG index quartiles (Q1: < 8.20; Q2: 8.20–8.53; Q3: 8.54–8.92; Q4: > 8.92). There were significant differences in age, body mass index, systolic blood pression, diastolic blood pressure, lipid-lowering agents, infarct location, fasting blood glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, uric acid, and stroke recurrence among the 4 groups. In the multi-adjusted models, compared to Q1 of the TyG index, the odds ratio for Q4 of the TyG index for stroke recurrence was 3.100 (1.366–8.019). The Kaplan–Meier survival (ischemic stroke-free) curves by quartiles of the TyG index also showed statistically significant differences (log-rank test, P = 0.004). Conclusions Our findings suggested that the TyG index was associated with ischemic stroke recurrence in nondiabetic patients with small vessel occlusion, and it could be a valuable biomarker for assessing the risk of ischemic stroke recurrence in these patients.

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Section: Introductionsupporting

confidence: 55%

Association of triglyceride-glucose index with ischemic stroke recurrence in nondiabetic patients with small vessel occlusion: a multicenter hospital-based prospective cohort study

Zhu

et al. 2022

Cardiovasc Diabetol

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“…A higher TyG index was linked with an increased risk of early neurological deterioration and a decreased early neurological improvement in AIS patients with IV thrombolytic therapy. Particularly, the TyG index was closely correlated with early neurological deterioration in patients with subcortical infarcts near the middle cerebral artery [30]. It was reported that higher TyG index was related to increased mortality and poorer functional outcomes in both diabetic and non-diabetic patients [31], which con rmed our observation in this study.…”

Section: Multifactor Logistic Regression Analysissupporting

confidence: 89%

Predictive value of modified Thrive-c model in the prognosis of AIS patients after reperfusion therapy

Liu,

Yang,

et al. 2024

Preprint

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Purpose To explore the predictive value of combining the TyG index with the THRIVE score at admission for AIS patients following reperfusion therapy. Methods This retrospective study enrolled 284 AIS patients who had undergone reperfusion therapy. Patients were classified into good or poor prognosis groups based on their modified Rankin Scale (mRS) scores. We analyzed the relationship between the TyG index, the THRIVE score at admission, and the prognosis of AIS. We applied Spearman correlation analysis to investigate the correlation between the TyG index and the THRIVE score at admission against the 90-day mRS scores of AIS patients post-reperfusion. The study developed a logistic regression analysis model to establish a combined predictive formula. ROC curves were constructed to evaluate the predictive power of the TyG index, the admission THRIVE score, their combined use, the THRIVE-c model, and the modified THRIVE-c model for AIS prognosis. Results There were significant differences observed between the groups with poor and good prognoses regarding diabetes, hypertension, atrial fibrillation, gender, NIHSS score at admission, admission THRIVE score, TyG index, triglycerides, and fasting blood glucose. Logistic regression analysis determined that both the TyG index and THRIVE score at admission serve as independent risk factors for poor 90-day prognosis in ischemic stroke patients. The combined predictive coefficient, the THRIVE-c model, and the modified THRIVE-c model yielded AUCs of 0.784, 0.81, and 0.847, respectively, indicating their reliable predictive efficacy. Conclusion Both the TyG index and the THRIVE score assessed at admission are significant independent predictors of adverse outcomes in AIS patients post-reperfusion therapy. The integration of these metrics, along with the THRIVE-c and modified THRIVE-c models, enhances the accuracy of prognosis prediction for AIS patients.

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“…5 The various studies have concluded that the higher triglyceride index is an important predictor of mortality and outcome of acute ischemic stroke. 6 Thus, the present study was undertaken to elucidate the association between TyG index in type 2 diabetes mellitus patients and acute ischemic stroke.…”

Section: Introductionmentioning

confidence: 99%

Association between Triglyceride glucose index in type 2 diabetes mellitus patients and acute ischemic stroke

Isha Koul,

Abhinav Gupta,

Ranjana Duggal

et al. 2023

AJD

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Background: The stroke is a leading cause of mortality and disability globally. Diabetes mellitus increases the risk of stroke. It was observed that the risk of stroke is usually higher among the young diabetic patients. It was evident that pre-diabetic patients have a great risk of stroke as the presence of glucose in blood results in vascular endothelial dysfunction, increased early-age arterial stiffness, systemic inflammation and thickening of the capillary basal membrane.In this study we aimed to determine the association between Triglyceride Glucose Index in Type-2 diabetes mellitus patients and acute ischemic stroke. Methods: The present prospective observational study was undertaken to elucidate the association between Triglyceride glucose index in type 2 diabetes mellitus patients and acute ischemic stroke.A total of 75 patients with acute ischemic stroke and had history of diabetes mellitus during the period of study were included in the study. Results: In our study the mean age of the patients was 58.74±11.37 years and the majority of the patients were males (57%) followed by 43% females. The average NIHSS score of study participants was 5. The mean FPG value was as 6.13±2.03 (mmol/l), mean TC was 5.76±1.4 (mmol/l), mean TG 1.98±0.93 was (mmol/l) and mean TyG index was 8.76±0.28. Conclusion: The present study concluded that the TyG index is an important risk factor of ischemic stroke as it was observed that the patients with higher TyG index has higher incidence of ischemic stroke.

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Triglyceride-Glucose Index and the Prognosis of Patients with Acute Ischemic Stroke: A Meta-Analysis

Cited by 8 publications

References 42 publications

Association of triglyceride-glucose index with ischemic stroke recurrence in nondiabetic patients with small vessel occlusion: a multicenter hospital-based prospective cohort study

Association of triglyceride-glucose index with ischemic stroke recurrence in nondiabetic patients with small vessel occlusion: a multicenter hospital-based prospective cohort study

Predictive value of modified Thrive-c model in the prognosis of AIS patients after reperfusion therapy

Association between Triglyceride glucose index in type 2 diabetes mellitus patients and acute ischemic stroke

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