Triglyceride glucose index as a predictor of mortality in middle-aged and elderly patients with type 2 diabetes in the US

Zhao, Mengjie; Xiao, Mengli; Tan, Qin; Lu, Fang

doi:10.1038/s41598-023-43512-0

Cited by 11 publications

(9 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Research on Chinese middle-aged and elderly diabetic patients revealed an elevated TyG index associated with an increased CVD risk [ 35 ]. Moreover, a study of individuals over 65 exhibited a robust correlation between the TyG index and all-cause/CVD mortality [ 36 ]. Despite the prevailing focus on older populations, studies in younger patients have also indicated the predictive value of the TyG index for CVD risk.…”

Section: Discussionmentioning

confidence: 99%

“…Notably, Zhao et al demonstrated that patients with a TyG index in the intermediate range (8.72–9.15) exhibited the lowest risk of CVD mortality. In contrast, individuals in both the high and low TyG index groups experienced a significantly increased risk of CVD death [ 36 ]. The heightened risk of death in the high TyG index group may be attributed to hyperglycemia and hyperlipidemia, which are already major risk factors for cardiovascular events.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The association between the triglyceride–glucose index and the risk of cardiovascular disease in US population aged ≤ 65 years with prediabetes or diabetes: a population-based study

Liu,

Liang

2024

Cardiovasc Diabetol

View full text Add to dashboard Cite

Background The relationship between the triglyceride–glucose (TyG) index and the risk of cardiovascular disease (CVD) in the U.S. population under 65 years of age with diabetes or prediabetes is unknown. The purpose of this study was to investigate the relationship between baseline TyG index and CVD risk in U.S. patients under 65 years of age with diabetes or prediabetes. Methods We used data from the 2003–2018 National Health and Nutrition Examination Survey (NHANES). Multivariate regression analysis models were constructed to explore the relationship between baseline TyG index and CVD risk. Nonlinear correlations were explored using restricted cubic splines. Subgroup analysis and interaction tests were also conducted. Results The study enrolled a total of 4340 participants with diabetes or pre-diabetes, with a mean TyG index of 9.02 ± 0.02. The overall average prevalence of CVD was 10.38%. Participants in the higher TyG quartiles showed high rates of CVD (Quartile 1: 7.35%; Quartile 2: 10.04%; Quartile 3: 10.71%; Quartile 4: 13.65%). For CVD, a possible association between the TyG index and the risk of CVD was observed. Our findings suggested a linear association between the TyG index and the risk of CVD. The results revealed a U-shaped relationship between the TyG index and both the risk of CVD (P nonlinear = 0.02583) and CHF (P nonlinear = 0.0208) in individuals with diabetes. Subgroup analysis and the interaction term indicated that there was no significant difference among different stratifications. Our study also revealed a positive association between the TyG index and comorbid MetS in the U.S. population under 65 years of age with prediabetes or diabetes. Conclusions A higher TyG index was linked to an increased likelihood of CVD in the U.S. population aged ≤ 65 years with prediabetes and diabetes. Besides, TyG index assessment will contribute to more convenient and effective screening of high-risk individuals in patients with MetS. Future studies should explore whether interventions targeting the TyG index may improve clinical outcomes in these patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The association between the triglyceride–glucose index and the risk of cardiovascular disease in US population aged ≤ 65 years with prediabetes or diabetes: a population-based study

Liu,

Liang

2024

Cardiovasc Diabetol

View full text Add to dashboard Cite

show abstract

“…Shen et al found that the TyG index is a predictive measure for the probability of death from any cause in older adults with acute coronary syndrome who also have diabetes [ 30 ]. Similar to that in older and middle-aged patients with type 2 diabetes, the TyG index may predict the likelihood of CVD-related mortality or death from any cause [ 31 ]. In participants with CVDs, the TyG index exhibited a U-shaped association with the risk of all-cause mortality [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…Over 50% of the cardiovascular deaths among CVD patients comprised older individuals over 75 years of age [ 6 ]. Zhao et al revealed a strong correlation between the TyG index and all-cause/CVD mortality in Americans with diabetes older than 65 years [ 31 ]. However, in our study, 82.7% of the participants were younger than 65 years, which might partially explain why the TyG index was not significantly correlated with cardiovascular mortality.…”

Section: Discussionmentioning

confidence: 99%

Triglyceride-glucose index predicts all-cause mortality, but not cardiovascular mortality, in rural Northeast Chinese patients with metabolic syndrome: a community-based retrospective cohort study

Yu,

Li,

Yang

et al. 2024

Nutr Metab (Lond)

View full text Add to dashboard Cite

Background Metabolic syndrome (MetS) includes a group of metabolic irregularities, including insulin resistance (IR), atherogenic dyslipidemia, central obesity, and hypertension. Consistent evidence supports IR and ongoing low-grade inflammation as the main contributors to MetS pathogenesis. However, the association between the triglyceride-glucose (TyG) index and mortality in people with MetS remains uncertain. The objective of this study was to examine the correlation between the baseline TyG index and all-cause and cardiovascular (CV) mortality in rural Northeast Chinese individuals with MetS. Methods For the Northeast China Rural Cardiovascular Health Study, 3918 participants (mean age, 55 ± 10; 62.4% women) with MetS at baseline were enrolled in 2012–2013 and followed up from 2015 to 2017. The TyG index was calculated using the equation TyG index = ln [fasting TG (mg/dL) × fasting glucose (mg/dL)/2] and subdivided into tertiles [Q1(< 8.92); Q2 (8.92–9.36); Q3 (≥ 9.36)]. Multivariate Cox proportional hazards models were developed to examine the correlations between mortality and the baseline TyG index. Results During a median of 4.66 years of follow-up, 196 (5.0%) all-cause deaths and 108 (2.8%) CV disease-related deaths occurred. The incidence of all-cause mortality was significantly different among TyG index tertiles of the overall population (P = 0.045). Kaplan–Meier analysis demonstrated a significantly increased risk of all-cause mortality in rural Chinese patients with a higher TyG index (log-rank P < 0.05). After adjusting for possible confounders, Cox proportional hazard analysis revealed that the TyG index could effectively predict all-cause mortality (HR for the third vs. first tertile of TyG was 1.441 [95% confidence interval, 1.009–2.059]), but not CV mortality, in rural Chinese patients with MetS. Conclusions The TyG index is an effective predictor of all-cause mortality in rural Chinese patients with MetS. This indicates that the TyG index may be useful for identifying rural Chinese individuals with MetS at a high risk of death.

show abstract

“…Similar to our findings, one study found a positive association between TyG index and CVD mortality when it exceeded 9.52 [ 26 ]. Zhao et al also found a positive association with CVD mortality when TyG index exceeded 9 [ 27 ]. Furthermore, it is noteworthy that certain studies have indicated a reduced risk of CVD mortality when the baseline TyG index falls below a specific threshold [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Association between the triglyceride–glucose index and all-cause and CVD mortality in the young population with diabetes

Liu,

Liang,

Xiao

et al. 2024

Cardiovasc Diabetol

View full text Add to dashboard Cite

Background Although studies have demonstrated the value of the triglyceride–glucose (TyG) index for cardiovascular disease (CVD) and cardiovascular mortality, however, few studies have shown that the TyG index is associated with all-cause or CVD mortality in young patients with diabetes. This study aimed to investigate the association between the TyG index and all-cause and CVD mortality in young patients with diabetes in the United States. Methods Our study recruited 2440 young patients with diabetes from the National Health and Nutrition Examination Survey (NHANES) 2001–2018. Mortality outcomes were determined by linking to National Death Index (NDI) records up to December 31, 2019. Cox regression modeling was used to investigate the association between TyG index and mortality in young patients with diabetes. The nonlinear association between TyG index and mortality was analyzed using restricted cubic splines (RCS), and a two-segment Cox proportional risk model was constructed for both sides of the inflection point. Results During a median follow-up period of 8.2 years, 332 deaths from all causes and 82 deaths from cardiovascular disease were observed. Based on the RCS, the TyG index was found to have a U-shaped association with all-cause and CVD mortality in young patients with diabetes, with threshold values of 9.18 and 9.16, respectively. When the TyG index was below the threshold value (TyG index < 9.18 in all-cause mortality and < 9.16 in CVD mortality), its association with all-cause and CVD mortality was not significant. When the TyG index was above the threshold (TyG index ≥ 9.18 in all-cause mortality and ≥ 9.16 in CVD mortality), it showed a significant positive association with all-cause mortality and CVD mortality (HR 1.77, 95% CI 1.05–2.96 for all-cause mortality and HR 2.38, 95% CI 1.05–5.38 for CVD mortality). Conclusion Our results suggest a U-shaped association between TyG index and all-cause and CVD mortality among young patients with diabetes in the United States, with threshold values of 9.18 and 9.16 for CVD and all-cause mortality, respectively.

show abstract

Triglyceride glucose index as a predictor of mortality in middle-aged and elderly patients with type 2 diabetes in the US

Cited by 11 publications

References 48 publications

The association between the triglyceride–glucose index and the risk of cardiovascular disease in US population aged ≤ 65 years with prediabetes or diabetes: a population-based study

The association between the triglyceride–glucose index and the risk of cardiovascular disease in US population aged ≤ 65 years with prediabetes or diabetes: a population-based study

Triglyceride-glucose index predicts all-cause mortality, but not cardiovascular mortality, in rural Northeast Chinese patients with metabolic syndrome: a community-based retrospective cohort study

Association between the triglyceride–glucose index and all-cause and CVD mortality in the young population with diabetes

Contact Info

Product

Resources

About