Triglyceride glucose index is associated with cerebral small vessel disease burden and cognitive impairment in elderly patients with type 2 diabetes mellitus

Teng, Zhenjie; Feng, Jing; Dong, Yanhong; Xu, Jing; Jiang, Xin; Chen, Huifang; Qi, Qianqian; Li, Rui; Chen, Weihong; Lv, Peiyuan

doi:10.3389/fendo.2022.970122

Cited by 23 publications

(29 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 22 Another recent cross-sectional study of the elderly aged 60 years and older indicated that the TyG index is an independent risk factor for cognitive impairment and severe cerebral small vessel disease burden in elderly patients with T2D. 23 As we mentioned earlier, cognitive impairment appears to develop earlier in T2D patients. Therefore, this study provides a possibility for the identification of MCI in patients aged 40 years and older with T2D.…”

Section: Introductionmentioning

confidence: 83%

Triglyceride Glucose Index is Related with the Risk of Mild Cognitive Impairment in Type 2 Diabetes

Tong¹,

Zhang²,

Yu³

et al. 2022

DMSO

View full text Add to dashboard Cite

Background The triglyceride glucose (TyG) index reflects insulin resistance; the latter being associated with mild cognitive impairment (MCI). Objective To investigate the clinical value of the TyG index to identify MCI in patients living with type 2 diabetes (T2D) using a cross-sectional study. Methods This cross-sectional study was performed on 517 patients with T2D. The diagnosis of MCI was based on criteria established by the National Institute on Aging-Alzheimer’s Association workgroup, and patients were divided into the MCI group and the normal cognitive function (NCF) group. The logistic regression analysis determines whether the TyG index is related to MCI. Subsequently, we constructed the receiver operating characteristic curve (ROC) and calculated the area under the curve (AUC). The nomogram model of the influence factor was established and verified. Results Compared to the type 2 diabetes-normal cognitive function (T2D-NCF) group, the MCI subjects were olderand had higher TyG indexes, lower cognitive scores, and lower education levels (p < 0.01). After adjusting for the confounders, the TyG index was associated with MCI (OR = 7.37, 95% CI = 4.72–11.50, p < 0.01), and TyG-BMI was also associated with MCI (OR = 1.02, 95% CI = 1.01–1.02, p<0.01). The TyG index AUC was 0.79 (95% CI = 0.76–0.83). The consistency index of the nomogram was 0. 83[95% CI (0. 79, 0. 86)]. Conclusion Our results indicate that the TyG index and TyG-BMI are associated with MCI in T2D patients, and the TyG index is an excellent indicator of the risk of MCI in T2D patients. The nomogram incorporating the TyG index is useful to predict MCI risk in patients with T2D.

show abstract

Section: Introductionmentioning

confidence: 83%

Triglyceride Glucose Index is Related with the Risk of Mild Cognitive Impairment in Type 2 Diabetes

Tong¹,

Zhang²,

Yu³

et al. 2022

DMSO

View full text Add to dashboard Cite

show abstract

“…Triglyceride-glucose (TyG) index, denoted ln [triglycerides (TG) (mmol/L) * fasting blood glucose (FBG) (mmol/L)/2], is a simple and reliable surrogate marker of insulin resistance [9]. Many previous studies have shown an association between a higher TyG index and an increased incidence of atherosclerosis, intima media thickness of common carotid artery, unstable carotid plaque, hypertension, arterial stiffness, and cardiovascular disease [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Association of triglyceride-glucose index with ischemic stroke recurrence in nondiabetic patients with small vessel occlusion: a multicenter hospital-based prospective cohort study

Zhu

et al. 2022

Cardiovasc Diabetol

View full text Add to dashboard Cite

Background Triglyceride-glucose (TyG) index is a simple and reliable surrogate marker of insulin resistance. Elevated TyG index was related to stroke recurrence. This study aimed to explore the associations between TyG index with ischemic stroke recurrence in nondiabetic patients with small vessel occlusion. Methods From November 1, 2016 to February 28, 2021, consecutive acute ischemic stroke patients admitted within 1 week after onset were screened. The stroke mechanism was determined based on medical history, laboratory examinations, cardiac examinations, vascular examinations and neuroimaging. Nondiabetic patients with small vessel occlusion were enrolled and followed up for 1 year. The primary outcome was ischemic stroke recurrence. Logistic regression and Kaplan–Meier survival curve were used to analyze the association of the TyG index and stroke recurrence. Results A total of 6100 acute ischemic stroke patients were screened, with 1970 nondiabetic patients with small vessel occlusion included and divided into 4 groups according to the TyG index quartiles (Q1: < 8.20; Q2: 8.20–8.53; Q3: 8.54–8.92; Q4: > 8.92). There were significant differences in age, body mass index, systolic blood pression, diastolic blood pressure, lipid-lowering agents, infarct location, fasting blood glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, uric acid, and stroke recurrence among the 4 groups. In the multi-adjusted models, compared to Q1 of the TyG index, the odds ratio for Q4 of the TyG index for stroke recurrence was 3.100 (1.366–8.019). The Kaplan–Meier survival (ischemic stroke-free) curves by quartiles of the TyG index also showed statistically significant differences (log-rank test, P = 0.004). Conclusions Our findings suggested that the TyG index was associated with ischemic stroke recurrence in nondiabetic patients with small vessel occlusion, and it could be a valuable biomarker for assessing the risk of ischemic stroke recurrence in these patients.

show abstract

“… 25 , 26 Total CSVD burden scores ≤2 were classified as mild CSVD burden and above 2 categorized as severe CSVD burden. 27 , 28 …”

Section: Methodsmentioning

confidence: 99%

“…25,26 Total CSVD burden scores ≤2 were classified as mild CSVD burden and above 2 categorized as severe CSVD burden. 27,28 304 24 items were used to assess anxiety or depression. According to previous studies, 29 the diagnosis of cognitive impairment was based on the optimal cut-off scores of MoCA: 0-13 for illiterate, 0-19 for 1-6 years of education, 0-24 for 7 or more years of education for Chinese adults.…”

Section: Assessment Of Total Csvd Burden Scoresmentioning

confidence: 99%

Subclinical Hypothyroidism is Associated with Cognitive Impairment in Patients with Cerebral Small Vessel Disease

Teng¹,

Feng²,

Lv³

2023

NDT

Self Cite

View full text Add to dashboard Cite

Objective To investigate the association between subclinical hypothyroidism (SCH) and cognitive function in patients with cerebral small vessel disease (CSVD). Methods We evaluated 528 patients with CSVD in this retrospective study. SCH was defined as elevated levels of thyroid stimulating hormone with normal concentrations of free thyroxine. Magnetic resonance imaging was performed to assess the total CSVD burden score and the Montreal Cognitive Assessment was used to measure the cognitive function. Participants were grouped based on cognitive function or total CSVD burden score. Multivariate logistic regression and mediation analysis models were used to estimate the association of SCH with cognitive function and CSVD burden. Results SCH was an independent risk factor for cognitive impairment in patients with CSVD after adjustment for potential confounding factors (OR: 1.939; 95% CI: 1.170 to 3.213; P =0.010). Additionally, SCH was independently associated with severe CSVD burden after adjustment for potential confounding factors (OR: 1.668; 95% CI: 1.085 to 2.564; P =0.020). Mediation analysis found a significant moderating effect ( P =0.021) of the severe CSVD burden on the relation between SCH and cognitive impairment after adjustment for potential confounding factors. A 30.1% of the total effect between this relation was attributable to the presence of severe CSVD burden. Conclusion SCH was associated with an increased risk of cognitive impairment in patients with CSVD. The mediating role of severe CSVD burden suggests that SCH may lead to cognitive impairment through the presence of severe CSVD burden. These findings may suggest strategies for screening for SCH in the context of cognitive impairment in patients with severe CSVD.

show abstract

Triglyceride glucose index is associated with cerebral small vessel disease burden and cognitive impairment in elderly patients with type 2 diabetes mellitus

Cited by 23 publications

References 38 publications

Triglyceride Glucose Index is Related with the Risk of Mild Cognitive Impairment in Type 2 Diabetes

Triglyceride Glucose Index is Related with the Risk of Mild Cognitive Impairment in Type 2 Diabetes

Association of triglyceride-glucose index with ischemic stroke recurrence in nondiabetic patients with small vessel occlusion: a multicenter hospital-based prospective cohort study

Subclinical Hypothyroidism is Associated with Cognitive Impairment in Patients with Cerebral Small Vessel Disease

Contact Info

Product

Resources

About