Triglyceride-glucose index is associated with symptomatic coronary artery disease in patients in secondary care

Abstract

Background The triglyceride-glucose index (TyG index) is a tool for insulin resistance evaluation, however, little is known about its association with coronary artery disease (CAD), which is the major cardiovascular death cause, and what factors may be associated with TyG index. Objective To evaluate the association between the TyG index and the prevalence of CAD phases, as well as cardiovascular risk factors. Methods The baseline data of patients in secondary care in cardiology from Brazilian Cardioprotective Nutritional Program Trial (BALANCE Program Trial) were analyzed. Anthropometric, clinical, socio-demographic and food consumption data were collected by trained professionals. The TyG index was calculated by the formula: Ln (fasting triglycerides (mg/dl) × fasting blood glucose (mg/dl)/2) and regression models were used to evaluate the associations. Results We evaluated 2330 patients, which the majority was male (58.1%) and elderly (62.1%). The prevalence of symptomatic CAD was 1.16 times higher in patients classified in the last tertile of the TyG index (9.9 ± 0.5) compared to those in the first tertile (8.3 ± 0.3). Cardiometabolic risk factors were associated with TyG index, with the highlight for higher carbohydrate and lower lipid consumption in relation to recommendations that reduced the chance of being in the last TyG index tertile. Conclusion The TyG index was positively associated with a higher prevalence of symptomatic CAD, with metabolic and behavioral risk factors, and could be used as a marker for atherosclerosis. Trial registration ClinicalTrials.gov identifier: NCT01620398. Registered 15 June, 2012 Electronic supplementary material The online version of this article (10.1186/s12933-019-0893-2) contains supplementary material, which is available to authorized users.

Associations between Triglyceride-Glucose Index and Micro- and Macro-Angiopathies in Type 2 Diabetes Mellitus

“…Few studies have reported associations between a high TyG index and the presence of coronary artery complications in type 2 DM and healthy adults [12,15,52]. In this study, we did not find a statistically significant association between the TyG index and CAD in the patients with type 2 DM.…”

“…Recently, the triglyceride-glucose (TyG) index was proposed as a simple and reliable surrogate marker of IR, and it has been reported to be closely correlated with the HOMA-IR index [8][9][10]. Previous clinical data have shown associations of the TyG index to the atherosclerotic cardiovascular diseases, including carotid atherosclerosis [11], coronary artery calcification [12], arterial stiffness [13,14], and CVD [15][16][17][18]. Additionally, our previous study showed that a higher TyG index was associated with an increased risk of cardiovascular events among patients with type 2 DM [19].…”

Triglyceride glucose index is an independent predictor for the progression of coronary artery calcification in the absence of heavy coronary artery calcification at baseline

“…A number of studies reported that the TyG index was related to the risk of developing traditional CV disease and adverse clinical events. Recent cross-sectional data from Brazilian Cardioprotective Nutritional Program Trial showed the positive association of TyG index with metabolic and behavioral risk factors [27]. In the present study, we identified that the incidence of CAC progression was elevated with an increasing TyG index irrespective of baseline CACS in this study.…”

Association of the insulin resistance marker TyG index with the severity and mortality of COVID-19

“…Previous studies have shown that the TyG index may predict the development of type 2 diabetes mellitus [12] and metabolic syndrome [13]. It has been reported that the TyG index is positively associated with the higher prevalence of subclinical coronary artery disease (CAD) [14], symptomatic CAD and metabolic and behavioral risk factors [15], and arterial stiffness and nephric microvascular damage [16]. Moreover, higher TyG index correlated with increased risk of main adverse cardiovascular and cerebrovascular events (MACCE) in acute ST-elevation myocardial infarction (STEMI) patients, and the TyG index might be a valuable predictor of clinical outcomes in STEMI patients undergoing percutaneous coronary intervention [17].…”