Triglyceride‐glucose index (TyG index) and endometrial carcinoma risk: A retrospective cohort study

Abstract

ObjectiveWe analyzed the association between the triglyceride‐glucose index (TyG index) and incident endometrial carcinogenesis, aiming to determine whether the TyG index is a promising predictive biomarker for endometrial carcinoma (EC).MethodsIn this retrospective cohort study, multiple logistic regression analysis was performed to evaluate the relationship between TyG index and EC incidence and progression. The receiver operating characteristic (ROC) curve was used to calculate the area under the curve (AUC), as well as the cut‐off value of the TyG index for EC incidence.ResultsThe TyG index was significantly higher in patients with EC or endometrial atypical hyperplasia (EAH) than in those with normal endometrium (P < 0.001). A continuous rise was observed in the incidence of EC and EAH among the tertiles of the TyG index (P < 0.001). The multiple logistic regression analysis revealed that the TyG index was associated with EC and EAH risk after adjusting for potential confounding factors (EAH: odds ratio [OR] 2.54, 95% confidence interval [CI] 1.33–4.85, P = 0.005; EC: OR 2.65, 95% CI 1.60–4.41, P < 0.001). Moreover, high TyG index was positively associated with advanced pathological stage (OR 2.14, 95% CI 1.32–3.47, P = 0.002) and poorer differentiation (OR 2.53, 95% CI 1.36–4.72, P = 0.004).ConclusionThe TyG index might be a promising biomarker for endometrial carcinogenesis. Subjects with a higher TyG index should be aware of the risk of EC incidence and progression.

Association between triglyceride-glucose index and risk of endometriosis in US population: results from the national health and nutrition examination survey (1999–2006)

“…TyG index, measured based on blood fasting triglycerides and glucose, has been recommended as an effective surrogate marker for insulin resistance, and could integrate the effect of both triglycerides as well as glucose on endometriosis (19). Numerous studies have demonstrated the potential of the TyG index in predicting the risk of various metabolism-related disorders (11)(12)(13)(14)(15). However, the relationship between the TyG index and endometriosis has not been explored yet.…”

“…Multiple epidemiological studies have demonstrated the association of TyG with a range of diseases, such as type 2 diabetes ( 11 ), cardiovascular disease ( 12 ), metabolic dysfunction-associated fatty liver disease ( 13 ) and gynecologic cancers ( 14 , 15 ). Given the potential involvement of metabolic disturbances in endometriosis pathogenesis, it is plausible to explore the association of insulin resistance with the risk of endometriosis.…”

The Importance of Metabolic Factors in Endometrial Cancer: Evaluating the Utility of the Triglyceride-to-Glycemia Index and Triglyceride-to-High-Density Lipoprotein Ratio As Biomarkers

“…They also confirmed that the TyG index remained an independent risk factor for both AEH (OR 2.54, 95% CI 1.33-4.85, P = 0.005) and EC (OR 2.65, 95% CI 1.60-4.41, P < 0.001). In addition, a high TyG index showed a positive correlation with a more advanced pathological stage (OR 2.14, 95% CI 1.32-3.47, P = 0.002) and poorer tumour differentiation (OR 2.53, 95% CI 1.36-4.72, P = 0.004) [ 29 ].…”