Triglyceride levels and apolipoprotein E polymorphism in patients with acute pancreatitis

Ivanova, Raisa; Puerta, S.; Garrido, Alfonso; Cueto, Ignacio; Ferro, Ana; Ariza, María José; Cobos, Andrés; González-Santos, Pedro; Valdivielso, Pedro

doi:10.1016/s1499-3872(11)60131-8

Cited by 40 publications

(23 citation statements)

References 36 publications

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“…The CFTR gene mutation rate in patients with HTG and AP was 26.1% (12 of 46), whereas in patients with HTG without AP only 1.3% (1 of 80) showed this specific CFTR gene mutation in this study [27]. A Spanish study by Ivanova et al finds the ε4 allele of the apolipoprotein E (APOE) gene more frequent in patients with HTG-AP, also suggesting a genetic background [7].…”

Section: Pathophysiological Concepts Of Htg-apcontrasting

confidence: 53%

“…Most patients with uncomplicated HTG-AP have a good prognosis; usually serum TG levels decrease in 24 to 48 h to a level in which the risk of AP is really low and reach values below 500 mg/dL at the fourth or fifth day [6,7]. Once pain disappears and intestinal transit is normalized, then an oral fat-free diet can be begun again.…”

Section: Diet and Initial Managementmentioning

confidence: 99%

“…However, hypertriglyceridemia (HTG) is a well known cause of AP and hypertriglyceridemia-induced acute pancreatitis (HTG-AP) is not a rare condition. In series of cases with AP, HTG was considered causative of the attack ranging from 1% up to 10% [4][5][6][7][8][9][10]. Some studies on gestational pancreatitis even report HTG as the underlying cause in more than half of all cases [11].…”

Section: Introductionmentioning

confidence: 99%

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Current knowledge of hypertriglyceridemic pancreatitis

Valdivielso¹,

Ramírez-Bueno²,

Ewald³

2014

European Journal of Internal Medicine

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359

311

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Section: Pathophysiological Concepts Of Htg-apcontrasting

confidence: 53%

Section: Diet and Initial Managementmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Current knowledge of hypertriglyceridemic pancreatitis

Valdivielso¹,

Ramírez-Bueno²,

Ewald³

2014

European Journal of Internal Medicine

Self Cite

359

311

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“…Furthermore, patients hospitalized and fully monitored by the Department of Gastroenterology, cases initially followed up in the Emergency Unit with a different diagnosis and diagnosed as acute pancreatitis after 48 hours, and patients referred from a different medical center were not enrolled in the trial. Pancreatitis was diagnosed by epigastric/periumbilical abdominal pain or abdominal pain radiating to the lumbar region/back, high amylase levels in the serum or urine (at least 3 times the upper limit of normal in serum), or by verification of pancreatitis on computerized tomography (5,11,12). In order to determine the appetite level, the visual analog scale (VAS) test was performed, in addition to information obtained from the patient's medical history.…”

Section: Methodsmentioning

confidence: 99%

Significance of appetite hormone ghrelin and obestatin levels in the assessment of the severity of acute pancreatitis

Kanat¹,

Ayten²,

Aydın³

et al. 2014

Turk J Gastroenterol

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Background/Aims: Due to risk of morbidity and mortality, various tests and scoring systems used in the assessment of the diagnosis and severity of acute pancreatitis disease are gaining more importance every day. Most of the current scoring systems, validated by various parameters, have a sophisticated and complex structure. Research is ongoing to establish a method to diagnose the disease and determine the severity by using different and simple parameters. In this trial, we aimed to investigate the role of the orexigenic "ghrelin" and anorexigenic "obestatin" hormones, if any, on the diagnosis and assessment of the severity of acute pancreatitis. Materials and Methods: A total of 30 patients hospitalized between September 2009 and September 2010 with a diagnosis of acute pancreatitis (AP) and 25 healthy volunteers were enrolled in the trial with a prospective and randomized design. The patients were classified in two groups, mild (Ranson ≤3 and / or Apache II ≤8) and severe (Ranson >3 and/or Apache II >8) cases, as per the Ranson and Apache-II criteria; the ghrelin and obestatin levels in blood samples obtained from the patients were measured using the ELISA method. Results: Twenty-two of the 30 patients (73%) were regarded as mild pancreatitis cases, while 8 cases (27%) were diagnosed as severe pancreatitis. Comparison of the mild and severe pancreatitis groups did not reveal a statistical difference between the two groups in terms of acylated and de-acylated ghrelin values on presentation and following the initiation of oral feeding. Similarly, no significant difference was found in the comparison of the patient and the control groups in terms of acylated and de-acylated ghrelin values on presentation (p=0.863). On the other hand, acylated and de-acylated ghrelin values after initiation of oral feeding were observed to be higher in the patient group (p=0.001, p=0.000). Comparison of these two groups revealed a significant difference in obestatin values, both on presentation and after initiation of oral feeding (p=0.002 and p=0.000). Conclusion: Consistently high serum ghrelin values during pancreatic inflammation suggest that ghrelin may be used as an adjunctive parameter in the monitoring of the course of the disease. On the other hand, high obestatin values in patients on presentation indicate that this hormone is a more significant parameter in terms of diagnosis. However, no correlation was established between these two peptide hormones and the severity of AP.

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“…1,2 In Greece, of 246 hospitalized AP patients, HLAP was diagnosed in approximately 6.9% of patients 3 and in about 10% of an Indian ethnic group. 4 It was reported in 2004 that HLAP was diagnosed in only 2.3% of patients in China.…”

mentioning

confidence: 99%