Triglyceride lowering effect of MaxEPA fish lipid concentrate: A multicentre placebo controlled double blind study

Miller, J P; Heath, I. D.; Choraria, S.; Shephard, N. W.; Gajendragadkar, R.V.; Harcus, A. W.; Batson, G A; Smith, D. W.; Saynor, R.

doi:10.1016/0009-8981(88)90233-1

Cited by 16 publications

(4 citation statements)

References 35 publications

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“…As compared to two other reports [31,35], fish oil treatment resulted in an approximately 10% decrease of serum trigylcerides and serum VLDL-cholesterol , serum HDL-and LDL-cholesterol levels increased to a minor extent. The effect of 3.5 g omega-3 fatty acids (fish oil) over a 4 mon period on triglyceride levels in the present study is somewhat lower than results given by Miller et al, who studied 86 hypertriglyceridemic patients with 3 g omega-3 fatty acids/ day over 3 mon [36].…”

Section: Franzen E T Alcontrasting

confidence: 83%

A prospective, randomized, and double‐blind trial on the effect of fish oil on the incidence of restenosis following ptca

Franzen

Schannwell

Oette

et al. 1993

Cathet. Cardiovasc. Diagn.

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Restenosis after successful coronary angioplasty (PTCA) occurs in 25-35% of all procedures. To date, most pharmacologic strategies have failed to reduce the restenosis rate significantly. However, recent studies have suggested a potential benefit of dietary supplementation with omega-3 fatty acids (fish oil) on restenosis following PTCA. The benefit of omega-3 polyunsaturated fatty acids on the incidence of coronary artery restenosis following elective PTCA was assessed in 212 consecutive patients (41 female, 171 male). Following a successful angioplasty, 204 patients received a dietary supplementation with either nine capsules containing fish oil (3.15 g omega-3 fatty acids) or nine placebo capsules containing olive oil. Treatment was started immediately after PTCA and maintained over 4 mon. Compliance was assessed by analysis of lipid fatty acids prior to angioplasty and at 4 mon follow-up. The angiographically determined incidence of restenosis (stenosis diameter > 50%) was 31.2% per lesion in patients receiving fish oil and 33.7% in patients receiving olive oil. Gross progression of coronary artery disease in vessels not subjected to angioplasty was 17% and 16%, respectively. In conclusion, low dose fish oil supplementation begun on the day of a successful coronary angioplasty failed to demonstrate any effect on coronary artery restenosis.

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Section: Franzen E T Alcontrasting

confidence: 83%

A prospective, randomized, and double‐blind trial on the effect of fish oil on the incidence of restenosis following ptca

Franzen

Schannwell

Oette

et al. 1993

Cathet. Cardiovasc. Diagn.

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“…Dietary supplementation with fish oils containing varying amounts of EPA and DHA have repeatedly demonstrated a TAG-lowering effect in both normolipidaemic ( 17 ) and hypertriacylglycerolaemic participants ( 18 , 19 ) . Early studies with EPA-rich fish oil suggested that EPA was the LC n -3 PUFA primarily responsible for conferring cardiovascular protection ( 31 ) . More recently, however, DHA has been implicated as equally if not more effective for cardioprotection ( 18 , 21 , 32 ) .…”

Section: Discussionmentioning

confidence: 99%

Regular consumption ofn-3 fatty acid-enriched pork modifies cardiovascular risk factors

et al. 2008

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The long-chain (LC) n-3 PUFA content of pork, particularly DHA, can be increased by including 15% PorcOmega (a fortified tuna fishmeal product) in pig finisher diets. The aim of the present study was to see whether this enriched pork could deliver cardiovascular health benefits to consumers. In a double-blind intervention trial, thirty-three healthy adult volunteers (sixteen female and seventeen male) were randomised to consume either n-3-enriched or regular (control) pork (a selection of five fresh cuts totalling 1000 g/week) for 12 weeks. Fasting blood samples were collected every 4 weeks and analysed for serum lipids, maximally stimulated thromboxane production and erythrocyte fatty acid composition. The n-3-enriched pork provided subjects with 1.3 g LC n-3 PUFA per week. Erythrocyte DHA levels rose 15% in the n-3 group and fell 5% in the control group over 12 weeks (P=0.001). Compared with the control group, serum TAG decreased to a greater extent in the n-3 group (P=0.02) and serum thromboxane production increased to a lesser extent (P=0.004). Changes in the latter were inversely associated with changes in incorporation of DHA into erythrocytes (r -0.54; P<0.05). Thus the modest increases in LC n-3 PUFA intake resulting from regular consumption of enriched pork can improve cardiovascular risk factors.

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“…Although mean triglyceride levels decreased in 68 of the 72 data sets, the decreases were not always statistically significant. Triglycerides were reduced significantly in 73% of the studies in hypertriglyceridemic patients (2,3,(15)(16)(17)(18)20,(22)(23)(24)(25)(26)(28)(29)(30)47,(49)(50)(51)(52)55,56,58), and in about 50% of studies with healthy subjects (4, 5,7,8,10,11,13,32,36,39,43-45, 59,61). Thus, it was not uncommon for the decrease in blood triglyceride levels to not reach statistical significance, especially in studies in normolipidemic subjects.…”

Section: Human Studiesmentioning

confidence: 98%

“…This exercise afforded the opportunity to ask if olive oil (the most commonly used placebo in these trials) was truly neutral vis-~t-vis circulating lipid levels. In the 33 data sets that used olive oil (or its ethyl esters) (5,7,9,12,(16)(17)(18)(19)(20)23,25,27,31,33,34,36,37,40,42,(44)(45)(46)(47)49,(51)(52)(53)(54)(55)57,59,61 ), the mean percentage changes (vs. baseline) in cholesterol, triglyceride, LDL-C, and HDL-C levels were -0.3, 2.3, -1.2, and 3.2%, respectively. Thus, about 10 g of olive oil per day had negligible effects on most lipoprotein fractions, with the possible exception of HDL-C.…”

Section: Human Studiesmentioning

confidence: 99%

n‐3 fatty acids and lipoproteins: Comparison of results from human and animal studies

Harris

1996

Lipids

236

153

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The impact of n-3 fatty acids (FA) on blood lipoprotein levels has been examined in many studies over the last 15 yr in both animals and humans. Studies in humans first demonstrated the potent triglyceride-lowering effect of n-3 FA, and these were followed up with animal studies to unravel the mechanism of action. This paper reviews the reported effects of n-3 FA on blood lipoproteins in 72 placebo-controlled human trials, at least 2 wk in length and providing 7 or less g of n-3 FA/day. Trials in normolipidemic subjects (triglycerides < 2.0 mM; 177 mg/dL) were compared to those in hypertriglyceridemic patients (triglycerides > or = 2.0 mM). In the healthy subjects, mean triglyceride levels decreased by 25% (P < 0.0001), and total cholesterol (C) levels increased by 2% (P < 0.009) due to the combined increases in low density lipoprotein (LDL)-C (4%, P < 0.02) and high density lipoprotein (HDL)-C (3%, P < 0.008). In the patients, triglyceride levels decreased by 28% (P < 0.0001), LDL-C rose by 7% (P < 0.0001), but neither total C nor HDL-C changed significantly. Although the effect on triglyceride levels is also observed in rats and swine, it is rarely seen in mice, rabbits, monkeys, dogs, and hamsters. Whereas n-3 FA have only a minor impact on lipoprotein C levels in humans, they often markedly lower both total C and HDL-C levels in animals, especially monkeys. These differences are not widely appreciated and must be taken into account when studying the effects of n-3 FA on lipoprotein metabolism.

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Triglyceride lowering effect of MaxEPA fish lipid concentrate: A multicentre placebo controlled double blind study

Cited by 16 publications

References 35 publications

A prospective, randomized, and double‐blind trial on the effect of fish oil on the incidence of restenosis following ptca

A prospective, randomized, and double‐blind trial on the effect of fish oil on the incidence of restenosis following ptca

Regular consumption ofn-3 fatty acid-enriched pork modifies cardiovascular risk factors

n‐3 fatty acids and lipoproteins: Comparison of results from human and animal studies

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