Triglyceride to high density lipoprotein cholesterol ratio among adolescents is associated with adult hypertension: the Kangwha study

Yeom, Hyungseon; Kim, Hyeon Chang; Lee, Ju Mi; Jeon, Yong Woo; Suh, Il

doi:10.1186/s12944-018-0861-y

Cited by 26 publications

(21 citation statements)

References 23 publications

(31 reference statements)

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“…Findings showed lower BMI reduced the risk of developing hypertension 43 . In recent years, a number of studies have shown that TG, HDL, LDL and TG can be used as predictors of essential hypertension events by constructing different models [44][45][46][47][48][49] . Fottrell et al surveyed a random sample of 12,280 adults >30 years old in 96 villages in rural Bangladesh and found that obesity, smoking, passive smoking and increased salt consumption were risk factors for hypertension 50 .…”

Section: Discussionmentioning

confidence: 99%

A novel predicted model for hypertension based on a large cross-sectional study

Ren

Rao

et al. 2020

Sci Rep

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Hypertension is a global public health issue and leading risk for death and disability. It is urgent to search novel methods predicting hypertension. Herein, we chose 73158 samples of physical examiners in central China from June 2008 to June 2018. After strict exclusion processes, 33570 participants with hypertension and 35410 healthy controls were included. We randomly chose 70% samples as the train set and the remaining 30% as the test set. Clinical parameters including age, gender, height, weight, body mass index, triglyceride, total cholesterol, low-density lipoprotein, blood urea nitrogen, uric acid, and creatinine were significantly increased, while high-density lipoprotein was decreased in the hypertension group versus controls. Nine optimal markers were identified by a logistic regression model, and achieved AUC value of 76.52% in the train set and 75.81% in the test set for hypertension. In conclusions, this study is the first to establish predicted models for hypertension using the logistic regression model in Central China, which provide risk factors and novel prediction method to predict and prevent hypertension. Hypertension which is a global public health issue is a leading risk for death and disability 1. It exacerbates the burden of kidney failure, stroke, and heart disease, as well as premature mortality and disability. The number of people with hypertension worldwide increased by 400 million in 2008, and about 40% of adults over the age of 25 are diagnosed with hypertension. The risk of death associated with systolic blood pressure increases significantly with increasing systolic blood pressure 2. Hypertension ranks first among all modifiable causes of cerebrovascular disease (CVD) and is the second preventable cause of death in the United States 3. By 2030, the number of global CVD-related deaths will exceed 23.3 million 4. It's reported by the World Health Organization (WHO) that global CAD cause approximately 17 million deaths each year 5 , of which approximately 9.4 million die from complications of hypertension 6. Hypertension accounts for at least 51% death of stroke and 45% death of heart diseases 5. In 2010, hypertension has been the leading cause of disability-adjusted life years and death. Then, the disability-adjusted life year caused by CAD was 366 million in 2017. Among them, the disability-adjusted life year caused by hypertensive heart disease was 16.5 million 7. The prevalence of hypertension in China was high (46.4%) in 2012-2015 according to the 2017 American College of Cardiology/American Heart Association guidelines 8. However, the awareness, control and treatment of hypertension are unsatisfactory 8. Thus, it is important and urgent to search a new method predicting hypertension. The increased prevalence of hypertension is due to behavioral risk factors, aging and population growth, such as persistent stress, being overweight, lack of physical exercise, harmful consumption of alcohol and unhealthy diet 9. The harmful effects of hypertension are complicated, including the in...

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Section: Discussionmentioning

confidence: 99%

A novel predicted model for hypertension based on a large cross-sectional study

Ren

Rao

et al. 2020

Sci Rep

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“…Se ha propuesto el índice Tg/HDL-C como un indicador efecti vo de adolescentes de 10 a 14 años que están en riesgo de desarrollar enfermedad cardiometabólica 24 e hipertensión arterial 25 . Diversos estudios han sugerido y usado diferentes puntos de corte para defi nir este índice como alto.…”

Section: Discussionunclassified

Índice triglicéridos/colesterol de alta densidad y perfil lipídico en adolescentes escolares de una región andina del Perú

Ortiz¹,

Romaní²

2018

An Fac med

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Introducción. El exceso de peso es un fenómeno creciente en población adolescente, sin embargo, los estudios sobre el perfil lipídico en adolescentes peruanos son escasos. Objetivo. Identificar los patrones del índice triglicéridos/colesterol HDL y perfil lipídico en escolares sin síndrome metabólico residentes en zonas urbanas de una región andina del Perú. Métodos. Estudio de fuente secundaria, los datos provienen del estudio «Frecuencia de Síndrome Metabólico en residentes de una región andina del Perú». De 586 estudiantes del estudio original, fueron excluidos 19 por tener diagnóstico de síndrome metabólico. Se analizaron los niveles de glucosa, colesterol total, colesterol de alta densidad (HLD), colesterol de baja densidad (LDL) y triglicéridos. El colesterol no HDL fue calculado mediante la diferencia entre el colesterol total y HDL. El índice triglicérido/colesterol de alta densidad (Tg/HDL-C) es el cociente entre la concentración sérica de triglicéridos y colesterol HDL-C. Resultados. Analizamos el perfil lipídico de 567 adolescentes entre 11 y 16 años. La media del índice Tg/HDL-C fue de 2,9 (desviación estándar – DE: 2,35), la mediana fue de 2,3 con un intervalo intercuartil entre 1,62 y 3,51. El índice Tg/HDL-C ≥3 estuvo asociado con mayores niveles de colesterol no HDL, puntaje Z de IMC y perímetro de cintura. Conclusiones. La mitad de adolescentes escolares de una región andina del Perú tuvo un índice Tg/HDL-C entre 1,62 y 3,51. Un corte ≥3 en el índice Tg/HDL-C estuvo asociado a una mayor concentración de colesterol no HDL, puntaje Z de IMC, y perímetro de cintura, estos dos últimos son indicadores de exceso de peso.

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“…This ratio is related to disorders and diseases of metabolism. During the 20-year follow-up found that to group with high triglyceride/HDL ratio is likely to have hypertension when compared with the group that has low ratio triglyceride/HDL ratio [14].…”

Section: Ratio Of Triglyceride/hdl Is the Ratio Between The Values Ofmentioning

confidence: 96%

Association of Gender, Triglyceride/HDL Ratio, and Physical Activity of Obese Adolescents in Makassar

Jafar

Syam

Kurniati

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Obesity may cause the increase of triglyceride and decrease of high-density lipoprotein (HDL) levels. Triglyceride/HDL ratio is associated with metabolic disorders. Physical activity is one of the important aspects in preventing obesity. Gender is known to have a relationship with these factors, but it has been inconsistent. AIM: This study aimed to evaluate the relationship between sex and triglycerides, levels of HDL, triglycerides/HDL ratio, and physical activity of obese adolescents in Makassar. METHODS: This study used a cross-sectional design involving 93 samples of obese adolescents from three high schools. Measurement of triglyceride and HDL levels was performed by the Prodia laboratory, while physical activity was measured using the International Physical Activity Questioner. Data analysis was performed with Chi-square and Fisher’s exact tests. RESULTS: The results showed that there is a relationship between gender and triglyceride levels (p = 0.006) and HDL (p = 0.034), but no relationship between the ratio of TG/HDL (p = 0.109) and physical activity was found (p = 0.339). CONCLUSION: Efforts should be made to reduce the level of risk adolescent obesity on the risk of metabolic syndrome and cardiovascular disease, including increase physical activity. Physical activity is important to maintain the physical and mental of obese adolescents.

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Triglyceride to high density lipoprotein cholesterol ratio among adolescents is associated with adult hypertension: the Kangwha study

Cited by 26 publications

References 23 publications

A novel predicted model for hypertension based on a large cross-sectional study

A novel predicted model for hypertension based on a large cross-sectional study

Índice triglicéridos/colesterol de alta densidad y perfil lipídico en adolescentes escolares de una región andina del Perú

Association of Gender, Triglyceride/HDL Ratio, and Physical Activity of Obese Adolescents in Makassar

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