Triglyceride to High-Density Lipoprotein Ratio can predict coronary artery calcification

Wang, Beilei; Hua, Jinsheng; Ma, Likun

doi:10.12669/pjms.38.3.5290

Cited by 5 publications

(1 citation statement)

References 28 publications

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“…While high TG levels are associated with insulin resistance and atherosclerosis [ 17 , 18 , 19 ], HDL-C promotes reverse cholesterol transport, removes excess cholesterol from arteries, and exerts anti-inflammatory and antioxidant properties [ 13 ]. In the past few years, the TG/HDL-C ratio has emerged as a surrogate marker for metabolic syndrome [ 20 , 21 ], increased CV risk [ 22 , 23 , 24 , 25 ], increased ischemic stroke risk [ 24 , 26 ], and CKD progression [ 27 ] and an independent predictor for all-cause mortality [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Non-Interventional Weight Changes Are Associated with Alterations in Lipid Profiles and in the Triglyceride-to-HDL Cholesterol Ratio

Weinstein,

Maor,

Kaplan

et al. 2024

Nutrients

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Background: Obesity is associated with dyslipidemia, and weight loss can improve obese patients’ lipid profile. Here, we assessed whether non-interventional weight changes are associated with alterations in lipid profile, particularly the triglyceride (TG)-to-high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C). Methods: In this retrospective analysis of subjects referred to medical screening, body mass index (BMI), low-density lipoprotein cholesterol (LDL-C), TG, and HDL-C levels were measured annually. Patients were divided according to BMI changes between visits. The primary outcomes were the changes in LDL-C, TG, HDL-C, and the TG/HDL-C ratio between visits. Results: The final analysis included 18,828 subjects. During the year of follow-up, 9.3% of the study population lost more than 5% of their weight and 9.2% gained more than 5% of their weight. The effect of weight changes on TG and on the TG/HDL-C ratio was remarkable. Patients with greater BMI increases showed greater increases in their TG/HDL-C ratio, and conversely, a decreased BMI level had lower TG/HDL-C ratios. This is true even for moderate changes of more than 2.5% in BMI. Conclusions: Non-interventional weight changes, even modest ones, are associated with significant alterations in the lipid profile. Understanding that modest, non-interventional weight changes are associated with alterations in the TG/HDL-C ratio may aid in better risk stratification and primary prevention of CV morbidity and mortality.

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Section: Introductionmentioning

confidence: 99%

Non-Interventional Weight Changes Are Associated with Alterations in Lipid Profiles and in the Triglyceride-to-HDL Cholesterol Ratio

Weinstein,

Maor,

Kaplan

et al. 2024

Nutrients

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Colchicine effect on biomarkers of cardiac remodelling and atherosclerosis in ST‐elevation myocardial infarction: A randomized controlled trial

Hassanain,

El Wakeel,

Khorshid

et al. 2024

Brit J Clinical Pharma

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AimsOwing to its underlying inflammatory nature, atherosclerotic cardiovascular disease remains the leading global cause of mortality, particularly post‐ST‐elevation myocardial infarction (STEMI), a condition with significant risk for further cardiovascular events and mortality. This study aimed to investigate colchicine's effect on inflammation, cardiac remodelling and atherosclerotic risk in STEMI patients.MethodsWe conducted a randomized controlled study on 88 STEMI patients undergoing percutaneous coronary intervention. Eligible patients were randomly assigned to 1 of 2 groups. The control group received the guideline‐directed medical therapy for STEMI, and the test group received guideline‐directed medical therapy and 0.5 mg colchicine twice daily for 3 months. The soluble suppressor of tumorigenicity (sST2), interleukin‐1β, lipid profile parameters, triglyceride (TG)/high‐density lipoprotein (HDL‐C) ratio levels and left ventricular ejection fraction were evaluated for patients at baseline and the end of the 3 months.ResultsNo significant effects were reported for colchicine on sST2, interleukin‐1β levels or left ventricular ejection fraction. Colchicine significantly lowered TG levels vs. controls, 134 (46–353) vs. 176 (72–825) respectively, P = .02, as well as TG/HDL‐C ratio levels, 4.16 (2.75–5.24) vs. 5.11 (3.51–8.33),` respectively, P = .024. sST2 levels of the studied cohort were positively correlated with their TG/HDL‐C ratio levels (R = .459, P < .001) at the end of follow‐up.ConclusionOur study highlights a promising impact of colchicine on atherosclerosis and cardiac remodelling factors in STEMI patients. Colchicine significantly reduced TG levels and TG/HDL‐C ratio and was safe and well tolerated. Larger long‐term studies powered to assess clinical outcomes of remodelling are necessary to confirm its beneficial effects in STEMI.Clinicaltrial.gov registration IDNCT06054100.

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Triglyceride to High-Density Lipoprotein ratio as a predictor for 10-year cardiovascular disease in individuals with diabetes in Thailand

Poochanasri,

Lertsakulbunlue,

Kookanok

et al. 2024

Preprint

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Background Cardiovascular disease (CVD) represents a group of disorders affecting the heart and blood vessels. The Framingham Heart Study (FHS) predicted a 10-year CVD risk score is used to establish risk stratification and evaluate intervention outcomes. TG/HDL ratio is utilized as an alternative tool to assess CVD risk. This study, therefore, aims to investigate the role of the TG/HDL ratio in predicting the 10-year cardiovascular risk utilizing the established FHS risk prediction model in individuals with T2DM. Methods A cross-sectional study was conducted among 61,004 patients with T2DM without a history of CVD aged between 30–74 years. From 2014, 2015, and 2018. The predicted 10-year CV risk was calculated using laboratory-based Framingham heart study equations. The cut point of TG/HDL was calculated using Youden’s J statistics of the ROC curve for predicting high predicted 10-year CV risk. Linear and Multivariable logistic regression analyses were performed to investigate the association between TG/HDL and high predicted 10-year CVD risk. Results For the overall participant group, ROC curve analysis yielded an AUC of 0.62 (95% CI 0.61–0.62) for predicting high FHS-CVD risk, with a TG/HDL cutoff value of 3.09 (Sensitivity 61%, Specificity 57%). Linear regression analysis revealed a dose-response relationship between the TG/HDL ratio and log-transformed predicted 10-year CV risk across both sexes and all age groups. Participants with high TG/HDL ratios (> 3.09) were positively associated with a prevalence of high FHS-CVD risk (AOR: 5.91, 95% CI 5.52–6.31). In comparison with participants in the first TG/HDL quartile (< 2.05), those in the fourth quartile (> 4.91) had a higher chance of high predicted 10-year CV risk (AOR: 18.27, 95% CI 16.537–20.185). Subgroup analysis revealed that the strength of association was more intense in females and those of advanced age. Conclusions TG/HDL can be used as a risk factor to determine predicted 10-year CV risk, particularly in individuals with T2DM aged between 30–74 years. However, further study is necessary to robustly establish the association between TG/HDL and cardiovascular disease risk prediction.

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Triglyceride to High-Density Lipoprotein Ratio can predict coronary artery calcification

Cited by 5 publications

References 28 publications

Non-Interventional Weight Changes Are Associated with Alterations in Lipid Profiles and in the Triglyceride-to-HDL Cholesterol Ratio

Non-Interventional Weight Changes Are Associated with Alterations in Lipid Profiles and in the Triglyceride-to-HDL Cholesterol Ratio

Colchicine effect on biomarkers of cardiac remodelling and atherosclerosis in ST‐elevation myocardial infarction: A randomized controlled trial

Triglyceride to High-Density Lipoprotein ratio as a predictor for 10-year cardiovascular disease in individuals with diabetes in Thailand

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