Triglycerides, independent of Ferriman Gallwey Score, is a main determinant of free testosterone index in PCOS

Abstract

<ns4:p><ns4:bold>Background:</ns4:bold> Polycystic Ovarian Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, affecting 5-20% of women worldwide. Hyperandrogenism, as the primary characteristic of PCOS, is not always present in every patient. The hyperandrogenic phenotype of PCOS patients is influenced by both hormonal and metabolic dysfunctions. Therefore, this study aims to determine the correlation between hormone profile, lipid profile, and clinical profile with free testosterone index in subjects with PCOS.</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> This prospective cross-sectional study was conducted in the Dr. Cipto Mangunkusumo General Hospital between July 2014 and December 2016. The study involved 76 women with PCOS, who were classified into 2 subgroups: 39 subjects in the hyperandrogenism group and 37 subjects in the non-hyperandrogenism group. Each subject underwent physical examination, blood sample collection, and USG examination. Bivariate analysis was done using independent t-tests and Mann Whitney U-tests, while multivariate analysis was done using logistic regression.</ns4:p><ns4:p> <ns4:bold>Results:</ns4:bold> Triglyceride and testosterone level showed weak (r = 0.232, p = 0.044) and moderate (r = 0.460, p ¡ 0.001) positive correlation with FTI, while SHBG level showed moderate negative correlation (r = -0.483, p ¡ 0.001). Triglyceride was also found to be determinant of hyperandrogenism condition in PCOS patient (OR 0.02, 95% CI 0.00–0.04, p = 0.013). However, there was no significant difference observed between FGS and hyperandrogenism (p = 0.43).</ns4:p><ns4:p> <ns4:bold>Conclusions:</ns4:bold> Triglycerides, testosterone, and SHBG were associated with hyperandrogenism in PCOS patients, while FGS showed no such association.</ns4:p>

The Associations between Sex Hormones and Lipid Profiles in Serum of Women with Different Phenotypes of Polycystic Ovary Syndrome

“…In addition, in our study in the whole group of women with PCOS as well as in patients with phenotype 1 of PCOS, we found a significant correlation between HDL-C (negative) or TG (positive) level and TT or FT concentration. A recent study of Hestiantoro et al [36] also suggested that TG is the main determinant of FT level in PCOS and hypothesized that phenotype 1 is influenced by both hormonal and metabolic dysfunctions. Furthermore, the authors also observed that SHBG was negatively correlated with FT [36].…”

“…A recent study of Hestiantoro et al [36] also suggested that TG is the main determinant of FT level in PCOS and hypothesized that phenotype 1 is influenced by both hormonal and metabolic dysfunctions. Furthermore, the authors also observed that SHBG was negatively correlated with FT [36]. The review provided by Qu and Donnelly [37] also suggested a close association between the SHBG concentration and changes in lipids and indicated that serum SHBG levels may be a useful diagnostic biomarker and therapeutic target for managing women with PCOS, though more clinical studies are needed to assess the usefulness of SHBG as a biomarker for identifying young women who may later develop PCOS.…”

Can Total Thrombus-formation Analysis System (T-TAS®) better predict coagulation disturbances than conventional laboratory measurements in patients with polycystic ovary syndrome?

“…Plasma TG can increase the expression of PAI-1, which predisposes to antifibrinolytic state and impaired lipid profile predicts better type 2 diabetes later in life than obesity [9]. TG was also found to be a determinant of hyperandrogenism conditions in PCOS patients [10].…”

Dysbiosis of the Saliva Microbiome in Patients With Polycystic Ovary Syndrome

“…Approximately 70% PCOS patients have been reported to have dyslipidemia and triglycerides is a main determinant of free testosterone index in PCOS ( Hestiantoro et al., 2019 ). In addition, abnormal glucose tolerance and insulin resistance were observed in many PCOS patients ( Bhathena, 2011 ; Jones et al., 2012 ).…”