Triglycerides-to-HDLC Ratio as a Marker of Cardiac Disease and Vascular Risk Factors in Adults

Ain, Qurat Ul; Asif, Naveed; Alam, Amir; Gilani, Mehwish; Shahzad, Noreen; Sheikh, Waqas

doi:10.29271/jcpsp.2019.11.1034

Cited by 13 publications

(16 citation statements)

References 14 publications

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“…Since DRG volume was smaller in smokers when compared to non-smokers, and since it is known that smoking causes microvascular damage, it seems likely that damage to the DRG microcirculation is a contributing factor to DRG atrophy in DPN (Tesfaye et al, 2005;Clair et al, 2015). This hypothesis is further supported by the finding of a positive correlation between L5 DRG SI and triglycerides/HDL ratio, since an increase in the latter has been reported to be associated with microvascular pathology (Ain et al, 2019). The correlation of serum triglycerides with both clinical symptom severity and reduced DRG volume is in line with data from clinical studies that have found elevated triglycerides to be a risk factor for nerve damage and increased severity of neuropathic symptoms in DPN.…”

Section: Discussionmentioning

confidence: 82%

Diabetic Polyneuropathy Is Associated With Pathomorphological Changes in Human Dorsal Root Ganglia: A Study Using 3T MR Neurography

et al. 2020

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Diabetic neuropathy (DPN) is one of the most severe and yet most poorly understood complications of diabetes mellitus. In vivo imaging of dorsal root ganglia (DRG), a key structure for the understanding of DPN, has been restricted to animal studies. These have shown a correlation of decreased DRG volume with neuropathic symptom severity. Our objective was to investigate correlations of DRG morphology and signal characteristics at 3 Tesla (3T) magnetic resonance neurography (MRN) with clinical and serological data in diabetic patients with and without DPN. In this cross-sectional study, participants underwent 3T MRN of both L5 DRG using an isotropic 3D T2weighted, fat-suppressed sequence with subsequent segmentation of DRG volume and analysis of normalized signal properties. Overall, 55 diabetes patients (66 ± 9 years; 32 men; 30 with DPN) took part in this study. DRG volume was smaller in patients with severe DPN when compared to patients with mild or moderate DPN (134.7 ± 21.86 vs 170.1 ± 49.22; p = 0.040). In DPN patients, DRG volume was negatively correlated with the neuropathy disability score (r = −0.43; 95%CI = −0.66 to −0.14; p = 0.02), a measure of neuropathy severity. DRG volume showed negative correlations with triglycerides (r = −0.40; 95%CI = −0.57 to −0.19; p = 0.006), and LDL cholesterol (r = −0.33; 95%CI = −0.51 to −0.11; p = 0.04). There was a strong positive correlation of normalized MR signal intensity (SI) with the neuropathy symptom score in the subgroup of patients with painful DPN (r = 0.80; 95%CI = 0.46 to 0.93; p = 0.005).

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Section: Discussionmentioning

confidence: 82%

Diabetic Polyneuropathy Is Associated With Pathomorphological Changes in Human Dorsal Root Ganglia: A Study Using 3T MR Neurography

et al. 2020

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“…Our results are consistent with most other studies. [28][29][30] HDL-c was constantly independently and inversely related to the risks of hyperglycemia, hypertension and hyperuricemia. Therefore, an insufficient HDL-c volume in patients with dyslipidemiaassociated diseases became the basis for clinical attempts to treat patients with dyslipidemia by increasing the level of HDL-c.…”

Section: Discussionmentioning

confidence: 99%

<p>Association of the HDL-c Level with HsCRP, IL-6, U-NAG, RBP and Cys-C in Type 2 Diabetes Mellitus, Hypertension, and Chronic Kidney Disease: An Epidemiological Survey</p>

Li¹,

Su²,

Gao³

et al. 2020

DMSO

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Purpose: To explore the association between the anti-inflammatory and renal protective roles of high-density lipoprotein cholesterol (HDL-c) and its different levels in type 2 diabetes mellitus (T2D), hypertension (HTN), and chronic kidney disease (CKD) and to lay a theoretical basis for precise, maximum-benefit HDL-c-raising therapy for patients with these diseases. Patients and Methods: A total of 2127 participants (195 with T2D, 618 with HTN, 162 with CKD, and 1152 controls) were selected and divided into four groups according to their baseline HDL-c level, namely, low HDL-c (L-HDL-c, ≤1.03 mmol/L), medium HDL-c (M-HDL-c, 1.04-1.55 mmol/L), high HDL-c (H-HDL-c, 1.56-2.05 mmol/L) and extremely high HDL-c (E-HDL-c, ≥ 2.06 mmol/L). Serum and morning urine samples were collected to analyze the correlation between high-sensitivity C-reactive protein (HsCRP), interleukin-6 (IL-6), urine n-acetyl-β-d-glucosidase (U-NAG), retinol binding protein (RBP), and cystatin c (Cys-C) levels with the HDL-c levels. Results: The HDL-c levels of patients with T2D, HTN and CKD were universally lower than those in the control group in both sexes (p<0.05), while male patients also manifested a lower level of HDL-c than female patients. However, although they had lower values of the renal impairment index, female patients were found to have anomalously higher amounts of proinflammatory cytokines. In addition, the correlations between HsCRP and RBP levels and HDL-c levels were most significant in patients with HTN (p<0.05), whereas in patients with T2D and CKD, such relevance was less significant. Conclusion: Existence of substantial differences in HDL-c levels between different types of disease and sex highlighted that a higher HDL level does not always predict a better clinical outcome of patients. Moreover, we found that both HsCRP and RBP correlated negatively with HDL-c in HTN patients, indicating that monitoring HsCRP and RBP may serve as indicators for therapeutic efficacy of HDL-c-raising medications in HTN patients.

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“…5 The TG/HDL-c ratio correlates directly with plasma LDL-c levels, type B, 5,8 reported as an independent CVR factor. 5 To identify cardiac and metabolic threats, it is important to use different TG/ HDL-c ratio cutoff points between genders, 5,11 as the HDL-c level is higher in women. 5 Different cutoff values for men and women are, in fact, used in the National Cholesterol Education Program's (NCEP) criteria for metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…Other studies have identified associations between the TG/HDL-c ratio and several cardiometabolic risk factors, such as alcohol use, 7 smoking, 8 metabolic syndrome, 23,24 oxidative 25 and inflammatory profiles, 12,25 adverse events, 10,26 various anthropometric parameters, 5,8,9,24,27 dyslipidemias, 12,24,27 HA. 5,8,11 DM, 5,8,11,24,28 insulin resistance, 11,23,28,29 and renal function. 30 In this sense, the cutoff points found represent the CVR well and are therefore good risk markers for the studied population.…”

Section: Discussionmentioning

confidence: 99%

“…5,[7][8][9] The TG/HDL-c ratio, proposed by Gaziano et al 10 as a strong lipid predictor for acute myocardial infarction, has been used as an indicator of dyslipidemias 8 and cardiometabolic risks (obesity, AH and DM), 5,[7][8][9] being a potent predictor of the development of CAD. 8,9,11 The TG/HDL-c ratio dispenses with personnel and specialized techniques, 12 it is a safe, economical, fast-to-obtain, practical, and easy-to-use atherogenic marker. 2,7 For these reasons, its use can be especially considered in PHC.…”

Section: Data Collectionmentioning

confidence: 99%

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Optimal Cutoff of the TG/HDL-c ratio for Cardiovascular Risk in Hypertensive and Diabetic Patients Monitored by Primary Health Care in a city in Minas Gerais

Silva¹,

Cotta²,

Mendonça³

et al. 2021

International Journal of Cardiovascular Sciences

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Currently, cardiovascular diseases (CVD) are one of the most important public health problems in the world and one of the main causes of prolonged hospitalization and health expenditures in Brazil. 1,2 Among CVD, coronary artery disease (CAD) stands out as the leading cause of death in Brazil 3,4 and worldwide. 3 Dyslipidemias are related to the development of atherosclerosis and, consequently, CAD. 5 Early detection of individual cardiovascular risk (CVR) is important to prevent CVD, 1,5,6 define therapy 6 and reduce complications 1 and mortality. 5 CVD prevention is a public health priority, especially in high-risk individuals, such as those diagnosed with arterial hypertension (AH) or Diabetes Mellitus (DM). The use of CVR predictors is important in clinical practice, 2,7,8 and the analysis of the atherogenic potential of lipid profile by biomarkers predicts CAD better than the isolated analysis of lipids, as it reflects the interactions between atherogenic and protective lipid fractions. 9

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Triglycerides-to-HDLC Ratio as a Marker of Cardiac Disease and Vascular Risk Factors in Adults

Abstract: Objective: To find out correlation of triglycerides-to-HDL cholesterol ratio in elders with cardiac risk factors like obesity, diabetes, and hypertension.

Cited by 13 publications

References 14 publications

Diabetic Polyneuropathy Is Associated With Pathomorphological Changes in Human Dorsal Root Ganglia: A Study Using 3T MR Neurography

Diabetic Polyneuropathy Is Associated With Pathomorphological Changes in Human Dorsal Root Ganglia: A Study Using 3T MR Neurography

<p>Association of the HDL-c Level with HsCRP, IL-6, U-NAG, RBP and Cys-C in Type 2 Diabetes Mellitus, Hypertension, and Chronic Kidney Disease: An Epidemiological Survey</p>

Optimal Cutoff of the TG/HDL-c ratio for Cardiovascular Risk in Hypertensive and Diabetic Patients Monitored by Primary Health Care in a city in Minas Gerais

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