Triglycerides to High-Density Lipoprotein Cholesterol Ratio Can Predict Impaired Glucose Tolerance in Young Women with Polycystic Ovary Syndrome

Song, Do Kyeong; Lee, Hyejin; Sung, Yeon Ah; Oh, Jee Young

doi:10.3349/ymj.2016.57.6.1404

Cited by 21 publications

(14 citation statements)

References 31 publications

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“…In a previous study with a smaller sample size of Iranian women with PCOS, the best cut-off point of TG/HDL-C and TC/HDL-C levels were 3.19 )sensitivity of 63.6%, specificity of 84.4%) and 4.37 )sensitivity of 69.7%, specificity of 65.6%), respectively [ 7 ]. In another study on the young Korean women with PCOS, the cut-off value of the TG/HDL-C ratio to predict the IR (estimated by the HOMA-IR index) was reported as 2.5 (sensitivity of 61%, specificity of 82%) [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of lipid ratios and triglyceride-glucose index as risk markers of insulin resistance in Iranian polycystic ovary syndrome women

et al. 2020

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Background Insulin resistance has a vital role in the pathophysiology of polycystic ovary syndrome (PCOS). Previous investigations have shown that some lipid ratios could be a simple clinical indicator of insulin resistance (IR) in some disorders and ethnicities. The present study was conducted to evaluate the correlation between triglyceride to HDL-cholesterol (TG/HDL-C), total cholesterol to HDL-cholesterol (TC/HDL-C), as well as fasting triglyceride-glucose (TyG) indices with IR (as measured by homeostasis model assessment of IR (HOMA-IR), quantitative insulin sensitivity check index (QUICKI) and fasting glucose to insulin ratio (FGIR)) among the Iranian women diagnosed with PCOS. Methods In the current study, a total of 305 women with PCOS were evaluated. TG/HDL-C, TC/HDL-C, and TyG indices were calculated. Fasting insulin level was measured using ELISA technique. IR was defined as a HOMA-IR value of ≥2.63, FG-IR value of < 8.25, and QUICKI value of < 0.33. Results The insulin-resistant (IR) and insulin-sensitive (IS) groups, established by the HOMA-IR, FG-IR, and QUICKI values were different in terms of TG/HDL-C, TC/HDL-C, and TyG indices. These indices were associated with IR even after adjusting for age and BMI. ROC curve analyses showed that TyG, TG/HDL-C, and TC/HDL-C strongly predicted HOMA-IR with area under the curve (AUC) of 0.639, 0.619, and 0.623, respectively (P < 0.05). Further, TC/HDL-C was a good predictor of FG-IR with AUC of 0.614 (P = 0.04). Conclusion TyG, TG/HDL-C, and TC/HDL-C indices might be good indicators of IR among Iranian women diagnosed with PCOS.

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Section: Discussionmentioning

confidence: 99%

Evaluation of lipid ratios and triglyceride-glucose index as risk markers of insulin resistance in Iranian polycystic ovary syndrome women

et al. 2020

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“…Many recent studies have shown that the triglyceride glucose (TyG) index is associated with IR, as assessed by hyperinsulinemic euglycemic clamp testing and HOMA-IR. Thus, the TyG index has been proposed as a reliable and simple surrogate marker of IR [ 7 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

Association between triglyceride glucose index and arterial stiffness in Korean adults

Lee

Ahn

Lee

et al. 2018

Cardiovasc Diabetol

211

220

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BackgroundThe triglyceride glucose (TyG) index has been suggested as a simple surrogate marker of insulin resistance. However, there are limited data regarding the association between the TyG index and arterial stiffness in adults. Therefore, we evaluated the relationship between the TyG index and arterial stiffness as measured based on brachial ankle pulse wave velocity (baPWV) in Korean adults.MethodsA total of 3587 subjects were enrolled in this study. Anthropometric and cardiovascular risk factors were measured. The TyG index was calculated as ln[fasting triglycerides(mg/dl) × fasting glucose(mg/dl)/2], and the insulin resistance index of homeostasis model assessment (HOMA-IR) was estimated. Arterial stiffness was determined by measuring baPWV.ResultsThe subjects were stratified into four groups based on the TyG index. There were significant differences in cardiovascular parameters among the groups; the mean baPWV increased significantly with increasing TyG index. According to the logistic regression analysis after adjusting for multiple risk factors, the odds ratio (95% CI) for increased baPWV (> 75th percentile) for the highest and lowest quartiles of the TyG index was 2.92 (1.92–4.44) in men and 1.84 (1.15–2.96) in women, and the odds ratio for increased baPWV for the highest and lowest quartiles of the HOMA-IR was 1.80 (1.17–2.78) in men and 1.46 (1.06–2.47) in women, respectively.ConclusionThe TyG index is more independently associated with increased arterial stiffness than HOMA-IR in Korean adults.

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“…TGL:HDL ratio is simple, cost-effective and useful tool to assess insulin resistance and cardiovascular disease in PCOS (Song et al, 2016). The highlight of the present study is the elevation of CRR-1, CRR-2 and markers of insulin resistance HOMA-IR and HOMA -adiponectin in PCOS women with TGL:HDL ≥ 3 that revealed the valuable effect of adiponectin against dyslipidemic environment.…”

Section: Resultsmentioning

confidence: 63%

Hypoadiponectinemia and high TG/HDLc ratio as risk markers of insulin resistance in obese PCOS women

Meera¹,

A²,

Vinodhini³

et al. 2020

ijrps

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PCOS is characterized by reduced insulin sensitivity and cardiovascular risk. Adiponectin, plays a major role that favours insulin sensitivity and possess vaso-protective function. TG:HDLc ratio, an inexpensive tool predicts insulin resistance. Study aims to relate adiponectin and TG:HDLc ratio with insulin resistance in obese infertile women with PCOS. In this cross-sectional observational study, as per Rotterdam’s criteria 129 obese PCOS women with BMI ≥ 23 were compared with 110 aged matched controls with BMI < 23. Cardiac risk ratio-1 (TC:HDLc) and 2 (LDLc:HDLc) were calculated. Insulin resistance represented as HOMA-IR, HOMA-adiponectin and triglyceride HDLc ratio (TG:HDLc) were calculated. Adiponectin levels was significantly lowered and pearson correlation showed negative correlation with TC, TGL, LDL, TC:HDLc, LDL:HDLc and TGL:HDLc; whereas strongly positive correlation with HDLc. TG:HDL ratio was significantly elevated (4.23 ± 0.81) in 64% of PCOS women and were insulin resistant as divulged by the elevation of HOMA-IR and HOMA-adiponectin. Simple linear regression analysis of adiponectin with TGL:HDLc (R2 = 0.68) LDLc (R2 = 0.84) HDLc (R2 = 0.86) revealed the association between variables. Adiponectin and TGL:HDLc ratio are useful markers of insulin resistance that relates to the threat of cardiovascular diseases in obese women with PCOS.

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Triglycerides to High-Density Lipoprotein Cholesterol Ratio Can Predict Impaired Glucose Tolerance in Young Women with Polycystic Ovary Syndrome

Cited by 21 publications

References 31 publications

Evaluation of lipid ratios and triglyceride-glucose index as risk markers of insulin resistance in Iranian polycystic ovary syndrome women

Evaluation of lipid ratios and triglyceride-glucose index as risk markers of insulin resistance in Iranian polycystic ovary syndrome women

Association between triglyceride glucose index and arterial stiffness in Korean adults

Hypoadiponectinemia and high TG/HDLc ratio as risk markers of insulin resistance in obese PCOS women

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