Trigonella Foenum Graecum Extract Benefits on Hematological, Biochemical and Male Reproductive System of as a Complementary Therapy with Glimepiride in Treating Streptozotocin Induced Diabetic Rats

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder. Streptozotocin is a naturally occurring cytotoxic chemical, particularly toxic to the pancreas and insulin producing beta cells in mammals and induces diabetes. Glimepiride is a second generation sulfonylurea, used as second-line or add-on treatment options for type 2 diabetes. Fenugreek (Trigonellafoenum graecum) seeds have been documented as a traditional plant treatment for diabetes. Soluble dietary fiber of Fenugreek significantly improved oral glucose tolerance in diabetic rats. It also exerts anti-diabetic effects mediated through the inhibition of carbohydrate digestion and absorption and the enhancement of peripheral insulin action. Most herbal remedies can interact with allopathic drugs resulting in altered activity and toxicity. At the same time, herbal remedies might produce the same kind of effects as the drug produce. Current published research information on herb-drug interactions is scanty. So, the aim of this study was to investigate the possible interaction between conventional drug used for the management of diabetes; (Glimepiride) and a traditional herbal remedy; Fenugreek aqueous extract in Streptozotocin induced diabetic male albino rats. In conclusion, combination therapy induces better hematological, biochemical effects and improves the oxidative stress biomarkers and antioxidant enzymes. Histological studies showed better results on some organ functions. The results emphasize the benefit of using the combination of Fenugreek seeds aqueous extracts as supportive complementary anti-diabetic therapy.

Interaction Between Ator and Fennel Remedies in the Treatment of Obesity in Rats

“…In the present study, the rats which treated with fennel herb indicates significant increase in the antioxidant, this results agreed with Kooti et al [72] reported that medicinal herbs have fewer side effects than synthetic drugs and due to their antioxidant properties they reduce drugs toxicity. The natural effective ingredients cause biological balance and prevent drug accumulation in body [73,18]. Medicinal plants can be used in the treatment of various diseases [72,18].…”

Evaluation of ameliorating role of avocado Persea americana fruit extract against monosodium glutamate-induced toxicity in pregnant female albino rats and their offspring

“…The glomeruli are reduced as a result of these modifications[52]. The diabetic rats displayed glomerular shrinkage, tubular casts, and inflammatory cellular infiltration[52]. Rats on a high-fat diet for two weeks displayed more inflammatory cells, cardiac muscle fibers in decline, and round and clogged blood arteries[53].Conclusion: Based on our findings, avocado fruit extract has a powerful ameliorative role against MSGinduced nephrotoxicity in pregnant rats and their neonates.…”

“…Diabetic rats' kidney tissue exhibited enlarged basement membranes of the proximal and distal convoluted tubules, increased glycogen deposition, and increased mesangial cell and matrix of glomeruli. The glomeruli are reduced as a result of these modifications[52]. The diabetic rats displayed glomerular shrinkage, tubular casts, and inflammatory cellular infiltration[52].…”

EXPERIMENTAL STUDY TO DETECT THE EFFECT OF GINKGO-BILOBA ON the liver, brain and the heart of INDUCED ISCHEMIC STROKE RATS.

“…Kidney sections of diabetic rats showed an increase in mesangial cells and matrix of glomeruli with an increase in glycogen deposition and hyalinization of arteries with thickened basement membranes of proximal and distal convoluted tubules. These changes lead to a reduction in the glomeruli (Elghazaly et al, 2019b). The diabetic rats showed tubular casts, inflammatory cellular infiltration and glomerular atrophy (Elghazaly et al, 2019b).…”

“…These changes lead to a reduction in the glomeruli (Elghazaly et al, 2019b). The diabetic rats showed tubular casts, inflammatory cellular infiltration and glomerular atrophy (Elghazaly et al, 2019b).…”