Trigonelline promotes auditory function through nerve growth factor signaling on diabetic animal models

Castañeda, Rodrigo; Rodríguez, Isabel; Nam, Youn Hee; Hong, Bin Na; Kang, Tong Ho

doi:10.1016/j.phymed.2017.09.023

Cited by 21 publications

(14 citation statements)

References 25 publications

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“…A total of 6 administrations of STZ within 4 weeks induces stable hyperglycemia and diabetic complications including retinopathy, nephropathy, and impaired fin regeneration. Alloxan can also selectively kill β-cells in zebrafish larvae (Nam et al, 2015 ; Castañeda et al, 2017 ). However, these compounds also exhibit other toxicity.…”

Section: Zebrafish Diabetes Modelsmentioning

confidence: 99%

Zebrafish as a Model for Obesity and Diabetes

Zang

Maddison

Chen

2018

Front. Cell Dev. Biol.

220

152

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Obesity and diabetes now considered global epidemics. The prevalence rates of diabetes are increasing in parallel with the rates of obesity and the strong connection between these two diseases has been coined as “diabesity.” The health risks of overweight or obesity include Type 2 diabetes mellitus (T2DM), coronary heart disease and cancer of numerous organs. Both obesity and diabetes are complex diseases that involve the interaction of genetics and environmental factors. The underlying pathogenesis of obesity and diabetes are not well understood and further research is needed for pharmacological and surgical management. Consequently, the use of animal models of obesity and/or diabetes is important for both improving the understanding of these diseases and to identify and develop effective treatments. Zebrafish is an attractive model system for studying metabolic diseases because of the functional conservation in lipid metabolism, adipose biology, pancreas structure, and glucose homeostasis. It is also suited for identification of novel targets associated with the risk and treatment of obesity and diabetes in humans. In this review, we highlight studies using zebrafish to model metabolic diseases, and discuss the advantages and disadvantages of studying pathologies associated with obesity and diabetes in zebrafish.

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Section: Zebrafish Diabetes Modelsmentioning

confidence: 99%

Zebrafish as a Model for Obesity and Diabetes

Zang

Maddison

Chen

2018

Front. Cell Dev. Biol.

220

152

View full text Add to dashboard Cite

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“…Trigonelline is also found in fenugreek and coffee. Trigonelline is of interest, as several studies have shown that it may be beneficial to treat or prevent diabetes and the symptoms of diabetes, hearing loss, and nonalcoholic fatty liver disease [23,24,25,26,27,28,29]. For this reason, the levels of trigonelline were investigated further in our population.…”

Section: Resultsmentioning

confidence: 99%

NMR Based Metabolomic Analysis of Health Promoting Phytochemicals in Lentils

et al. 2019

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Lentils are a high-protein plant food and a valuable source of human nutrition, particularly in the Indian subcontinent. However, beyond sustenance, there is evidence that the consumption of lentils (and legumes in general) is associated with decreased risk of diseases, such as diabetes and cardiovascular disease. Lentils contain health-promoting phytochemicals, such as trigonelline and various polyphenolics. Fourteen lentil genotypes were grown at three locations to explore the variation in phytochemical composition in hulls and cotyledons. Significant differences were measured between genotypes and environments, with some genotypes more affected by environment than others. However, there was a strong genetic effect which indicated that future breeding programs could breed for lentils that product more of these health-promoting phytochemicals.

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“…This study used a chemically induced model of diabetes caused by the death of pancreatic beta cells by alloxan. These cells are accountable for producing insulin, and hence, a metabolic disturbance occurs due to increased glycemic levels and reduced insulin levels, similar to diabetes mellitus [ 68 , 69 ].…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemic Activity of Aqueous Extract of Latex from Hancornia speciosa Gomes: A Study in Zebrafish and In Silico

et al. 2021

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Hancornia speciosa Gomes is a tree native to Brazil and has therapeutic potential for several diseases. Ethnopharmacological surveys have reported that the plant is used as a hypoglycemic agent and to lose weight. This study aimed to evaluate the effects of the aqueous extract from H. speciosa latex (LxHs) in a zebrafish model of diabetes. The extract was evaluated through high-performance thin-layer chromatography (HTPLC), nuclear magnetic resonance (NMR), and Fourier-transform infrared spectroscopy (FT-IR). We then tested treatments with LxHs (500, 1000, and 1500 mg/kg) by assessing blood glucose levels in alloxan-induced diabetic animals, and metformin was used as a control. The toxicity was evaluated through histopathology of the pancreas and biochemical assessment of serum levels of AST, ALT, creatinine, and urea. The extract was also assessed for acute toxicity through several parameters in embryos and adult animals. Finally, we performed in silico analysis through the SEA server and docking using the software GOLD. The phytochemical study showed the compounds cornoside, dihydrocornoide, and 1-O-methyl-myoinositol (bornesitol). The treatment with all doses of LxHs significantly decreased alloxan-induced hyperglycemia without any significant histological or biochemical abnormalities. No significant frequency of teratogenesis was observed in the embryos exposed to the extract, and no significant behavioral changes or deaths were observed in adult animals. In silico, the results showed a potential interaction between inositol and enzymes involved in carbohydrates’ metabolism. Overall, the results show a hypoglycemic activity of the extract in vivo, with no apparent toxicity. The computational studies suggest this could be at least partially due to the presence of bornesitol, since inositols can interact with carbohydrates’ enzymes.

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Trigonelline promotes auditory function through nerve growth factor signaling on diabetic animal models

Cited by 21 publications

References 25 publications

Zebrafish as a Model for Obesity and Diabetes

Zebrafish as a Model for Obesity and Diabetes

NMR Based Metabolomic Analysis of Health Promoting Phytochemicals in Lentils

Hypoglycemic Activity of Aqueous Extract of Latex from Hancornia speciosa Gomes: A Study in Zebrafish and In Silico

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