Trigothysoid N inhibits tumor proliferation and migration by targeting mitochondria and the STAT3/FAK pathway

Liu, Ying; Liu, Yuhui; Li, Yeling; Liu, Feng; Zhao, Yinan; Xu, Jing; Guo, Yuanqiang

doi:10.1016/j.arabjc.2023.104930

Cited by 3 publications

(6 citation statements)

References 47 publications

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“…In their study, Wisniewski et al [ 145 ] showed that, of the compounds derived from Euphorbia sp., latilagascene B is an effective P -glycoprotein inhibitor capable of increasing doxorubicin accumulation in resistant cells (human colon carcinoma LoVo cells). In contrast, Li et al [ 146 ] showed that Trigothysoid N, a natural diterpenoid isolated from Trigonostemon thyrsoideus , revealed a strong ability to inhibit the proliferation of A549 lung cancer cells through cell cycle arrest. In addition, the compound can inhibit tumor proliferation and migration by targeting mitochondria, regulating the signal transducer and activator of transcription 3/focal adhesion quinase) signaling pathway (STAT3/FAK), and inhibiting angiogenesis.…”

Section: The Euphorbiaceae Family Of Plantsmentioning

confidence: 99%

“…Changing the Bcl2/Bax (antiapoptotic/proapoptotic) protein balance could also be regulated by Euphorbiaceae plants through the STAT3 gene transcription pathway [ 146 ]. This balance is reported to be higher for Bax proteins than Bcl2 proteins when cancer cells are treated with Croton tiglium L., Euphorbia cactus Ehrenb.…”

Section: Potential Anticancer Mechanism Of Action Of Euphorbiaceae Ex...mentioning

confidence: 99%

“…ex Klotzsch, Euphorbia heterophylla L., Euphorbia helioscopia L., Euphorbia hierosolymitana Boiss., and Ricinus communis L. extracts [ 13 , 95 , 105 , 106 , 211 , 215 ]. Proapoptotic protein Bax is higher when cancer cells receive treatment with Trigothysoid N, Ebracteolatain A, and Ebracteolatain B also [ 146 , 232 ].…”

Section: Potential Anticancer Mechanism Of Action Of Euphorbiaceae Ex...mentioning

confidence: 99%

“…Li et al [ 146 ] reported that cell invasion and migration could be regulated by Trigothysoid N through the FAK pathway. Once the compound inhibits FAK, the transcription of metalloproteinase (MMP)-2 and MMP-9 is downregulated, and the cells are not able to invade or migrate to other tissues.…”

Section: Potential Anticancer Mechanism Of Action Of Euphorbiaceae Ex...mentioning

confidence: 99%

“…The cell cycle is regulated differently depending on the extract or pure compound used in cancer cells. In such a way that we can find stops in phase G1 [ 58 , 146 ], in phase G2/M [ 68 , 85 ], or in phase S [ 58 ] after the treatment with Euphorbiaceae. The anticancer potential mechanism of action of extracts and compounds from the Euphorbiaceae family is shown in Figure 3 below.…”

Section: Potential Anticancer Mechanism Of Action Of Euphorbiaceae Ex...mentioning

confidence: 99%

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Nature’s Green Potential: Anticancer Properties of Plants of the Euphorbiaceae Family

Jiménez-González,

Kowalczyk,

Piekarski

et al. 2023

Cancers

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The number of cancer cases will reach 24 million in 2040, according to the International Agency for Research on Cancer. Current treatments for cancer are not effective and selective for most patients; for this reason, new anticancer drugs need to be developed and researched enough. There are potentially useful drugs for cancer isolated from plants that are being used in the clinic. Available information about phytochemistry, traditional uses, in vitro and in vivo experiments with plants, and pure compounds isolated from the Euphorbiaceae family indicates that this family of plants has the potential to develop anticancer drugs. This review examines selected species from the Euphorbiaceae family and their bioactive compounds that could have potential against different types of cancer cells. It reviews the activity of crude extracts, isolated compounds, and nanoparticles and the potential underlying mechanisms of action.

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Section: The Euphorbiaceae Family Of Plantsmentioning

confidence: 99%

Section: Potential Anticancer Mechanism Of Action Of Euphorbiaceae Ex...mentioning

confidence: 99%

Section: Potential Anticancer Mechanism Of Action Of Euphorbiaceae Ex...mentioning

confidence: 99%

Section: Potential Anticancer Mechanism Of Action Of Euphorbiaceae Ex...mentioning

confidence: 99%

Section: Potential Anticancer Mechanism Of Action Of Euphorbiaceae Ex...mentioning

confidence: 99%

See 3 more Smart Citations

Nature’s Green Potential: Anticancer Properties of Plants of the Euphorbiaceae Family

Jiménez-González,

Kowalczyk,

Piekarski

et al. 2023

Cancers

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Bucidarasin A suppresses the proliferation and metastasis of HCC by targeting the FAK and STAT3 pathways

Hou,

Cao,

Wang

et al. 2024

Chemico-Biological Interactions

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Chlorahololide D, a Lindenane-Type Sesquiterpenoid Dimer from Chloranthus holostegius Suppressing Breast Cancer Progression

Li,

Liu,

et al. 2023

Molecules

Self Cite

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Aimed at discovering small molecules as anticancer drugs or lead compounds from plants, a lindenane-type sesquiterpene dimer, chlorahololide D, was isolated from Chloranthus holostegius. The literature review showed that there were few reports on the antitumor effects and mechanisms of chlorahololide D. Our biological assay suggested that chlorahololide D blocked the growth and triggered apoptosis of MCF-7 cells by stimulating the reactive oxygen species (ROS) levels and arresting the cell cycle at the G2 stage. Further mechanism exploration suggested that chlorahololide D regulated apoptosis-related proteins Bcl-2 and Bax. Moreover, chlorahololide D inhibited cell migration by regulating the FAK signaling pathway. In the zebrafish xenograft model, chlorahololide D was observed to suppress tumor proliferation and migration significantly. Considering the crucial function of angiogenesis in tumor development, the anti-angiogenesis of chlorahololide D was also investigated. All of the research preliminarily revealed that chlorahololide D could become an anti-breast cancer drug.

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Trigothysoid N inhibits tumor proliferation and migration by targeting mitochondria and the STAT3/FAK pathway

Cited by 3 publications

References 47 publications

Nature’s Green Potential: Anticancer Properties of Plants of the Euphorbiaceae Family

Nature’s Green Potential: Anticancer Properties of Plants of the Euphorbiaceae Family

Bucidarasin A suppresses the proliferation and metastasis of HCC by targeting the FAK and STAT3 pathways

Chlorahololide D, a Lindenane-Type Sesquiterpenoid Dimer from Chloranthus holostegius Suppressing Breast Cancer Progression

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